Role of Executive Control in Adolescent Substance Use and Co-occuring Problems

执行控制在青少年药物使用和同时发生的问题中的作用

• 批准号: 10239267
• 负责人: W Alex Mason
• 金额: $ 55.17万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10239267
• 关键词: Accidents; Adolescence; Adolescent; Age; Alcohol consumption; Behavior; Cause of Death; Child; Childhood; Data; Development; Developmental Process; Dimensions; Family; Gender; Goals; Growth Factor; Health; Homicide; Individual; Individual Differences; Intervention; Link; Longitudinal Studies; Marijuana; Measurement; Mediating; Mediator of activation protein; Methods; Morbidity - disease rate; National Institute of Drug Abuse; Nursery Schools; Outcome; Parents; Participant; Performance; Plant Roots; Prevention; Problem Solving; Problem behavior; Public Health; Research; Risk; Risk Factors; Role; Sampling; Schools; Social Development; Specific qualifier value; Strategic Planning; Suicide; Teenagers; Testing; Time; United States National Institutes of Health; Youth; adolescent substance use; adverse outcome; base; cigarette smoke; cognitive ability; cognitive process; critical developmental period; design; directed attention; early onset; elementary school; executive function; innovation; insight; intervention refinement; longitudinal design; marijuana use; model development; modifiable risk; mortality; neurodevelopment; peer; performance based measurement; prevent; preventive intervention; psychosocial; public health relevance; social; substance use; substance use prevention; young adult

Project Summary Adolescent substance use is a prevalent and significant public health concern. Although gains have been made in the development of effective substance use preventive interventions, there is room for improvement. Intervention refinements must be based on additional longitudinal research of developmental precursors that emerge well before substance use onset. Deficits in executive control (EC), a set of cognitive abilities for directing attention and behavior, have been proposed as important and modifiable contributors to adolescent problem behaviors, including substance use as well as co-occurring externalizing and internalizing problems. However, the early-emerging and dynamically-unfolding role of EC in the development of substance use and related problems is not well understood. Existing research lacks a long-term, developmentally-nuanced perspective, precluding an understanding of when and how poor EC impacts substance use risk. Preschool is a time of significant EC organization. Adolescence is a time of further EC development and differentiation, and the emergence of substance use. Yet, relevant studies spanning these critical developmental periods are lacking. This application proposes to extend an ongoing study of young children and their parents followed during preschool and the elementary school years with intensive, repeated, performance-based measures of EC (along with multi-rater, multi-method assessments of a broad array of additional factors) by collecting new data at ages 14, 15, 16, and 17. The long-term goal is to guide the development and refinement of substance use preventive interventions targeting EC as a modifiable risk factor at critical points in development. The objective of the proposed research is to explicate the long-term, dynamic impact of EC on the development of substance use and co-occurring problems. The central hypotheses are that poor EC in preschool, throughout childhood, and into adolescence will be related to the onset and growth of substance use and problem co- occurrence, and that these associations will be at least partially mediated by social developmental processes. The rationale is that a nuanced, longitudinal study of EC and substance use will richly inform the timing and targets of interventions focusing on EC to prevent adolescent substance use and related problems. The specific aims are to examine the long-term impact of EC in preschool (Aim 1) as well as the development of EC throughout childhood and adolescence (Aim 2) on adolescent substance use and co-occurring internalizing and externalizing problems, testing family, school, and peer mediating mechanisms (Aim 3) and exploring gender moderation (Exploratory Aim). The proposed project is innovative in its unique leveraging of early EC data from the sample and its rigorous and multifaceted measurement of EC over critical developmental periods. The significance of this research is that it will yield an unprecedented understanding of the impact of EC on substance use, affording new insights into when and how EC has its effects and providing information for designing optimally-timed, targeted interventions to bolster EC and prevent adolescent substance use.

项目摘要 青春期药物使用是一种普遍且重大的公共卫生问题。虽然收益已经 为了开发有效的药物使用预防干预措施，有改进的余地。 干预改进必须基于对发育前体的其他纵向研究， 在使用物质发作之前出现。执行控制的缺陷（EC），一组认知能力 指导注意力和行为已被提出为青少年的重要和可修改的贡献者 问题行为，包括使用物质以及共同出现外部化和内在化问题。 但是，EC在使用物质使用和 相关问题尚不清楚。现有研究缺乏长期，发展的 透视图，排除了何时以及如何影响EC影响物质使用风险的理解。学龄前是 重要的EC组织的时代。青春期是进一步的EC发展和分化的时期，并且 物质使用的出现。然而，涵盖这些关键发展时期的相关研究是 缺乏。该申请提议扩大对幼儿及其父母的持续研究 在学龄前和小学期间，以密集，重复，基于绩效的措施的措施 EC（以及多评价者的多种方法评估，对广泛的其他因素），通过收集新 14、15、16和17岁的数据。长期目标是指导物质的开发和完善 使用针对EC的预防干预措施作为开发中关键点的可修改风险因素。这 拟议的研究的目的是阐明EC对发展的长期，动态影响 物质使用和同时发生的问题。中心假设是幼儿园中的EC差 童年，进入青春期将与药物使用的发作和增长以及问题共同生长有关 发生，这些关联将至少由社会发展过程进行部分介导。 理由是，对EC和物质使用的细微努力研究将为时机提供丰富的信息和 侧重于EC的干预措施的目标，以防止青少年物质使用和相关问题。这 具体目的是检查EC在学龄前的长期影响（AIM 1）以及EC的发展 整个儿童期和青春期（目标2）在青春期使用和同时存在的内在化 以及外部化问题，测试家庭，学校和同伴中介机制（AIM 3）并探索 性别节制（探索目的）。拟议的项目具有创新的，其独特的EC的利用 样本的数据及其在关键发展中对EC的严格和多方面测量 时期。这项研究的意义在于，它将对 EC关于使用物质的EC，为何时以及如何具有效果并提供信息提供新的见解 用于设计最佳定时的，有针对性的干预措施，以增强EC并防止青少年使用。

项目成果

Childhood executive control and adolescent substance use initiation: the mediating roles of physical and relational aggression and prosocial behavior.

童年执行控制和青少年物质使用开始：身体和关系攻击以及亲社会行为的中介作用。

• DOI: 10.1080/09297049.2022.2079615
• 发表时间: 2023
• 期刊: Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence
• 作者: Patwardhan,Irina;Guo,Ying;Hamburger,EmilyR;Sarwar,Saira;Fleming,CharlesB;James,TiffanyD;Nelson,JenniferMize;Espy,KimberlyAndrews;Nelson,TimothyD;Mason,WAlex
• 通讯作者: Mason,WAlex

Executive Control in Early Childhood as an Antecedent of Adolescent Problem Behaviors: A Longitudinal Study with Performance-based Measures of Early Childhood Cognitive Processes.

• DOI: 10.1007/s10964-020-01316-9
• 发表时间: 2020-12
• 期刊: Journal of youth and adolescence
• 影响因子: 4.9
• 作者: Fleming CB;Stevens AL;Vivero M;Patwardhan I;Nelson TD;Nelson JM;James TD;Espy KA;Mason WA
• 通讯作者: Mason WA

A Comparison of Task-Based and Questionnaire Assessments of Executive Control Aspects in Relation to Adolescent Marijuana Initiation.

• DOI: 10.26828/cannabis/2023.01.006
• 发表时间: 2023-02-07
• 期刊: Cannabis (Albuquerque, N.M.)

Associations of Early Socio-familial Stress with Maladaptive and Adaptive Functioning in Middle Childhood: Roles of Executive Control and Foundational Cognitive Abilities.

早期社会家庭压力与童年中期适应不良和适应性功能的关联：执行控制和基础认知能力的作用。

• DOI: 10.1007/s11121-020-01119-1
• 发表时间: 2020
• 期刊: Prevention science : the official journal of the Society for Prevention Research
• 作者: Mason,WAlex;Fleming,CharlesB;Tomaso,CaraC;James,TiffanyD;Nelson,JenniferMize;Espy,KimberlyAndrews;Nelson,TimothyD
• 通讯作者: Nelson,TimothyD

Associations of childhood executive control with adolescent cigarette and E-cigarette use: Tests of moderation by poverty level.

• DOI: 10.1016/j.addbeh.2021.106923
• 发表时间: 2021-08
• 期刊: Addictive behaviors
• 影响因子: 4.4
• 作者: Alex Mason W;Patwardhan I;Fleming CB;Stevens AL;James TD;Nelson JM;Espy KA;Nelson TD
• 通讯作者: Nelson TD