Viscoelastic and volumetric contributions to age-related cognitive decline

粘弹性和体积对与年龄相关的认知能力下降的贡献

• 批准号: 10266862
• 负责人: Hillary Schwarb
• 金额: $ 7.93万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10266862
• 关键词: Age; Age-associated memory impairment; Aging; Alzheimer' s Disease; Assessment tool; Atrophic; Behavior; Behavioral; Biological; Brain; Brain region; Characteristics; Cognition; Cognitive; Corpus striatum structure; Data; Data Set; Development; Diagnosis; Disease; Eye Movements; Future; Health; Hippocampus (Brain); Human; Imaging Techniques; Impaired cognition; Impairment; Individual; Investigation; Learning; Liquid substance; Literature; Longevity; Magnetic Resonance Elastography; Magnetic Resonance Imaging; Measures; Mediating; Memory; Memory impairment; Methods; Neurologic; Outcome; Parkinson Disease; Participant; Patient-Focused Outcomes; Performance; Population; Positioning Attribute; Prevention; Process; Property; Proxy; Research; Resolution; Risk; Structure; Techniques; Tissues; Treatment outcome; Ursidae Family; Validation; Work; age related neurodegeneration; aging brain; behavior test; behavioral response; brain health; brain tissue; brain volume; cognitive ability; cognitive neuroscience; cognitive performance; cognitive process; cognitive testing; cost; effective intervention; gray matter; healthy aging; in vivo; learning ability; mechanical properties; neuroimaging; new technology; novel; novel strategies; pathological aging; relating to nervous system; relational memory; sequence learning; success; tool; viscoelasticity; visual tracking; young adult

PROJECT SUMMARY/ABSTRACT It is well understood that typical aging is accompanied by characteristic declines in fluid cognitive abilities as well as declines in the structural integrity of the brain. Structural integrity has typically been inferred from measures of brain volume. Volume, however, is a gross measure that cannot account for smaller-scale changes that may be contributing to diminished cognitive outcomes. Magnetic resonance elastography (MRE) is an emerging tool for acquiring noninvasive measures of the mechanical properties of biological tissue. As such, MRE provides a measure of the microstructural health of the tissue. The proposed work seeks (1) to assess the utility of MRE as a complementary tool to volumetric analysis in the study of human learning and memory and also (2) to establish MRE as a critically sensitive method for mapping degeneration in the aging brain, particularly when volumetric outcomes are equivocal. Volumetric, MRE, and cognitive data will be collected from 80 participants between the ages of 45 and 85. The cognitive assessment will measure both relational memory abilities (dependent on hippocampal function) and implicit sequence learning abilities (dependent on striatal function). Volumetric and MRE analyses will focus on the hippocampus and striatum specifically. These data will be used to examine the relationship between relational memory performance and both hippocampal volume and MRE-derived hippocampal viscoelasticity, as well as implicit sequence learning and both striatal volume and viscoelasticity, to explore the unique contribution of each to behavior. It is expected that, compared to volumetric measures alone, viscoelasticity measures will provide additional explanatory power when investigating the impact of tissue integrity on cognitive outcomes. This work will establish MRE as a useful tool for the study of cognitive neuroscience of aging and highlight the importance of choosing appropriate neuroimaging tools when assessing structural integrity. The resulting data will have important implications for tracking structural changes that impact cognitive abilities in typical aging as well as the diagnosis and tracking of treatment outcomes for patients with hippocampal (e.g., Alzheimer’s disease) and striatal (e.g., Parkinson’s disease) impairments.

项目概要/摘要 众所周知，典型的衰老伴随着流体认知能力的特征性下降，例如 以及大脑结构完整性的下降通常可以推断出。 然而，脑容量的测量是一个总体测量，无法解释较小规模的情况。 可能导致认知结果下降的变化。 是一种用于获取生物组织机械特性的非侵入性测量的新兴工具。 因此，MRE 提供了组织微观结构健康状况的衡量标准。拟议的工作旨在 (1)： 评估 MRE 作为体积分析的补充工具在人类学习研究中的效用 记忆以及 (2) 将 MRE 建立为绘制衰老退化图谱的极其敏感的方法 大脑，特别是当体积结果模棱两可时，体积、MRE 和认知数据将是不确定的。 从 80 名年龄在 45 岁到 85 岁之间的参与者中收集。认知评估将衡量 关系记忆能力（取决于海马功能）和内隐序列学习能力 （取决于纹状体功能）体积和 MRE 分析将重点关注海马体和纹状体。 具体来说，这些数据将用于检查关系内存性能和之间的关系。 海马体积和 MRE 衍生的海马粘弹性，以及隐式序列学习 以及纹状体体积和粘弹性，探索每种对行为的独特贡献。 预计与单独的体积测量相比，粘弹性测量将提供额外的 这项工作将在研究组织完整性对认知结果的影响时提供解释力。 将 MRE 确立为研究衰老认知神经科学研究的有用工具，并强调 结果数据将有 跟踪影响典型衰老过程中认知能力的结构变化具有重要意义 海马病患者（例如阿尔茨海默病）的诊断和治疗结果跟踪 纹状体（例如帕金森病）损伤。