Viscoelastic and volumetric contributions to age-related cognitive decline

粘弹性和体积对与年龄相关的认知能力下降的贡献

• 批准号: 10266862
• 负责人: Hillary Schwarb
• 金额: $ 7.93万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10266862
• 关键词: Age; Age-associated memory impairment; Aging; Alzheimer' s Disease; Assessment tool; Atrophic; Behavior; Behavioral; Biological; Brain; Brain region; Characteristics; Cognition; Cognitive; Corpus striatum structure; Data; Data Set; Development; Diagnosis; Disease; Eye Movements; Future; Health; Hippocampus (Brain); Human; Imaging Techniques; Impaired cognition; Impairment; Individual; Investigation; Learning; Liquid substance; Literature; Longevity; Magnetic Resonance Elastography; Magnetic Resonance Imaging; Measures; Mediating; Memory; Memory impairment; Methods; Neurologic; Outcome; Parkinson Disease; Participant; Patient-Focused Outcomes; Performance; Population; Positioning Attribute; Prevention; Process; Property; Proxy; Research; Resolution; Risk; Structure; Techniques; Tissues; Treatment outcome; Ursidae Family; Validation; Work; age related neurodegeneration; aging brain; behavior test; behavioral response; brain health; brain tissue; brain volume; cognitive ability; cognitive neuroscience; cognitive performance; cognitive process; cognitive testing; cost; effective intervention; gray matter; healthy aging; in vivo; learning ability; mechanical properties; neuroimaging; new technology; novel; novel strategies; pathological aging; relating to nervous system; relational memory; sequence learning; success; tool; viscoelasticity; visual tracking; young adult

PROJECT SUMMARY/ABSTRACT It is well understood that typical aging is accompanied by characteristic declines in fluid cognitive abilities as well as declines in the structural integrity of the brain. Structural integrity has typically been inferred from measures of brain volume. Volume, however, is a gross measure that cannot account for smaller-scale changes that may be contributing to diminished cognitive outcomes. Magnetic resonance elastography (MRE) is an emerging tool for acquiring noninvasive measures of the mechanical properties of biological tissue. As such, MRE provides a measure of the microstructural health of the tissue. The proposed work seeks (1) to assess the utility of MRE as a complementary tool to volumetric analysis in the study of human learning and memory and also (2) to establish MRE as a critically sensitive method for mapping degeneration in the aging brain, particularly when volumetric outcomes are equivocal. Volumetric, MRE, and cognitive data will be collected from 80 participants between the ages of 45 and 85. The cognitive assessment will measure both relational memory abilities (dependent on hippocampal function) and implicit sequence learning abilities (dependent on striatal function). Volumetric and MRE analyses will focus on the hippocampus and striatum specifically. These data will be used to examine the relationship between relational memory performance and both hippocampal volume and MRE-derived hippocampal viscoelasticity, as well as implicit sequence learning and both striatal volume and viscoelasticity, to explore the unique contribution of each to behavior. It is expected that, compared to volumetric measures alone, viscoelasticity measures will provide additional explanatory power when investigating the impact of tissue integrity on cognitive outcomes. This work will establish MRE as a useful tool for the study of cognitive neuroscience of aging and highlight the importance of choosing appropriate neuroimaging tools when assessing structural integrity. The resulting data will have important implications for tracking structural changes that impact cognitive abilities in typical aging as well as the diagnosis and tracking of treatment outcomes for patients with hippocampal (e.g., Alzheimer’s disease) and striatal (e.g., Parkinson’s disease) impairments.

项目摘要/摘要 众所周知，典型的衰老是通过流体认知能力的特征下降来完成的 以及大脑结构完整性的下降。结构完整性通常是从 大脑体积的度量。但是，数量是一个总测量，无法说明较小规模 可能导致认知结果降低的变化。磁共振弹性图（MRE） 是一种新兴工具，用于加快生物组织机械性能的无创测量。作为 这样，MRE提供了组织的微观结构健康。拟议的工作寻求（1） 评估MRE作为完成人类学习和研究和 记忆和（2）将MRE作为一种非常敏感的方法来映射老化的变性 大脑，特别是当体积结局等效时。体积，MRE和认知数据将是 从45至85岁之间的80名参与者收集。认知评估将衡量 关系记忆能力（取决于海马功能）和隐式序列学习能力 （取决于纹状体功能）。体积和MRE分析将集中在海马和纹状体上 这些数据将用于检查关系记忆性能与 海马体积和MRE衍生的海马粘弹性以及隐式序列学习 以及纹状体体积和粘弹性，以探索每种行为的独特贡献。这是 预计，与仅体积测量相比，粘弹性测量将提供额外 研究组织完整性对认知结果的影响时的剥夺能力。这项工作将 建立MRE作为研究衰老认知神经科学的有用工具，并强调 评估结构完整性时，选择适当的神经影像学工具。结果数据将具有 跟踪影响典型衰老以及影响认知能力的结构变化的重要含义 海马患者（例如，阿尔茨海默氏病）和 纹状体（例如帕金森氏病）障碍。