NORTHWESTERN UNIVERSITY PLUS CLINICAL SITE

西北大学加临床站点

• 批准号: 10248550
• 负责人: James William Griffith
• 金额: $ 40万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10248550
• 关键词: Activities of Daily Living; Adolescent; Adult; Affect; Assessment tool; Behavior; Biological; Biology; Bladder; Clinical; Clinical Research; Cohort Studies; Communities; Data; Development; Discrimination; Economic Burden; Education; Employment; Enrollment; Environmental Risk Factor; Epidemiology; Ethnic Origin; Evaluation; Foundations; Future; Goals; Gynecologist; Health; Health Insurance; Healthcare Systems; Heterogeneity; Income; Insurance Coverage; Interview; Leadership; Letters; Literature; Longevity; Longitudinal cohort study; Longitudinal observational study; Measurement; Measures; Medical; Medical center; Methodology; Methods; Mind; Minority; Minority Groups; Morbidity - disease rate; Not Hispanic or Latino; Outcome; Participant; Pathway interactions; Plant Roots; Population; Population Heterogeneity; Predictive Factor; Prevention; Prevention program; Prevention trial; Psyche structure; Psychologist; Quality of life; Race; Research; Research Personnel; Respondent; Risk; Risk Factors; Sampling; Screening procedure; Sensitivity and Specificity; Sex Orientation; Site; Social Well-Being; Societal Factors; Symptoms; Time; Translating; United States National Institutes of Health; Universities; Vulnerable Populations; Woman; Women' s Health; Work; Workplace; behavior influence; clinical research site; cohort; common symptom; community engaged research; community engagement; community organizations; community partnership; demographics; epidemiology study; ethnic minority population; experience; health disparity; health literacy; implementation science; implementation study; implicit bias; improved; knowledge base; longitudinal design; lower urinary tract symptoms; minority health; multidisciplinary; novel; physical state; prevent; programs; prospective; protective factors; psychologic; psychosocial; racial and ethnic; recruit; response; screening; social; social health determinants; success; urinary

Project Summary Lower urinary tract symptoms (LUTS) are common in women and negatively impact activities of daily living and quality of life, resulting in medical and psychological morbidity and enormous economic burden. Because of the deleterious consequences of LUTS on women, understanding optimal bladder health is essential. Given the complexity and heterogeneity of women with urinary symptoms, transdisciplinary research is needed to screen for risk factors for the development of bladder symptoms, protective factors that facilitate optimized bladder health, and mechanisms to target for prevention programs to disrupt causal pathways to bladder symptoms To date, the literature on LUTS has mostly focused on non-Hispanic White women with health insurance who present with symptoms and are already engaged with the healthcare system. Thus, extant prevention and treatment approaches are not generalizable to vulnerable populations like minority and underserved women. Significant gaps remain in understanding bladder health for minority and underserved women, where significant health disparities exist. Well-designed longitudinal cohort studies of urinary symptoms in diverse samples in which racial/ethnic minorities are well represented are severely lacking. Consistent with the PLUS Research Consortium, our objective is to move beyond the absence of symptoms and optimize bladder health as “a complete state of physical, mental, and social well-being related to bladder function.” Therefore, the primary goal of this project is to assess the influence of biological, psychosocial (mind/behavior), interpersonal, institutional, environmental, and societal factors on bladder health among diverse women using qualitative and quantitative approaches within the PLUS framework. The mixed- methods approach of this project includes: Specific Aim 1. Conduct a longitudinal, observational study of bladder health in a diverse cohort of adolescent and adult women with respect to race/ethnicity, age, income, education, health literacy, insurance status, sexual orientation, and employment, Specific Aim 2. Determine factors and behaviors that influence bladder health in diverse women, and Specific Aim 3. Create a screening tool for bladder health that is reliable and valid across diverse women. We hypothesize that social determinants of health, implicit bias, and discrimination will be significantly related to the trajectory of bladder health and engagement with the healthcare system over time for LUTS. We also hypothesize that the screener we develop will assess bladder health in all women (including diverse populations in which disparities exist) and will identify women at risk for future bladder symptoms with high reliability, validity, accuracy, sensitivity, and specificity and minimal burden to the respondent. The impact of this U01 will be the curation of a novel knowledge base on risk and protective factors in diverse populations of women.

项目概要 下尿路症状 (LUTS) 在女性中很常见，并对日常生活活动产生负面影响 和生活质量，导致医疗和心理疾病以及巨大的经济负担。 鉴于 LUTS 对女性的有害后果，了解最佳膀胱健康至关重要。 由于女性泌尿系统症状的复杂性和异质性，需要进行跨学科研究 筛查膀胱症状发展的危险因素、促进优化的保护因素 膀胱健康，以及破坏膀胱因果路径的预防计划的目标机制 症状 迄今为止，有关 LUTS 的文献主要集中在患有健康问题的非西班牙裔白人女性 出现症状并已参与医疗保健系统的保险因此存在。 预防和治疗方法不能推广到少数民族和少数民族等弱势群体 服务不足的女性在了解少数民族和服务不足的女性的膀胱健康方面仍存在重大差距。 女性，存在显着的健康差异。精心设计的泌尿纵向队列研究。 在少数种族/族裔具有充分代表性的不同样本中，严重缺乏症状。 与 PLUS 研究联盟一致，我们的目标是超越没有症状和 优化膀胱健康，将其视为“与膀胱相关的身体、心理和社会福祉的完整状态” 因此，该项目的主要目标是评估生物、心理社会的影响。 （心理/行为）、人际、制度、环境和社会因素对膀胱健康的影响 多元化的女性在 PLUS 框架内使用定性和定量方法。 该项目的方法包括： 具体目标 1. 进行纵向、观察性研究 不同群体的青少年和成年女性的膀胱健康状况，涉及种族/民族、年龄、收入、 教育、健康素养、保险状况、性取向和就业，具体目标 2. 确定 影响不同女性膀胱健康的因素和行为，以及具体目标 3. 创建筛查 对不同女性来说可靠且有效的膀胱健康工具。 健康的决定因素、隐性偏见和歧视将与健康的轨迹显着相关。 随着时间的推移，膀胱健康状况以及与医疗保健系统的参与度会随着时间的推移而增加。 我们开发的筛查仪将评估所有女性（包括不同人群）的膀胱健康状况 存在差异），并将以高可靠性、有效性、 U01 的准确性、敏感性和特异性以及给受访者带来的最小负担。 建立一个关于不同妇女群体的风险和保护因素的新知识库。