Open Platform for Online Simulations for Stimulating Peripheral Activity to Relieve Conditions - o2S2PARC

用于刺激外周活动以缓解病情的在线模拟开放平台 - o2S2PARC

• 批准号: 10244710
• 负责人: Niels Kuster
• 金额: $ 287.09万
• 依托单位: IT'IS FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-22 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10244710
• 关键词: Anatomic Models; Anatomy; Animals; Brain; Cloud Computing; Collaborations; Communities; Complex; Computer software; Coupled; Coupling; Data; Data Analyses; Dependence; Development; Devices; Electromagnetics; Electrophysiology (science); Elements; Ensure; Environment; Evaluation; Feedback; Frequencies; Human; Human body; Image; Infrastructure; Joints; Maintenance; Modeling; Nerve; Neurostimulation procedures of spinal cord tissue; Organ; Performance; Peripheral; Peripheral Nervous System; Physics; Physiology; Population; Positioning Attribute; Property; Safety; Software Tools; Source; Time; Tissues; Uncertainty; Vision; application programming interface; base; cost; data visualization; design; experience; file format; graphical user interface; interest; models and simulation; neuroprosthesis; neuroregulation; open source; precision medicine; programs; quality assurance; response; simulation; tool; treatment planning; user-friendly; verification and validation; virtual; Anatomic Models; Anatomy; Animals; Brain; Cloud Computing; Collaborations; Communities; Complex; Computer software; Coupled; Coupling; Data; Data Analyses; Dependence; Development; Devices; Electromagnetics; Electrophysiology (science); Elements; Ensure; Environment; Evaluation; Feedback; Frequencies; Human; Human body; Image; Infrastructure; Joints; Maintenance; Modeling; Nerve; Neurostimulation procedures of spinal cord tissue; Organ; Performance; Peripheral; Peripheral Nervous System; Physics; Physiology; Population; Positioning Attribute; Property; Safety; Software Tools; Source; Time; Tissues; Uncertainty; Vision; application programming interface; base; cost; data visualization; design; experience; file format; graphical user interface; interest; models and simulation; neuroprosthesis; neuroregulation; open source; precision medicine; programs; quality assurance; response; simulation; tool; treatment planning; user-friendly; verification and validation; virtual

o2S2PARC Y6 Abstract for NIH RePORTER IT’IS Foundation, SIM-Core SIM-Core’s mission is to ensure that the computational models and analyses developed under the SPARC program are accessible, sustainably preserved, reusable, and interoperable. To this end, a comprehensive, user-friendly Open platform for Online Simulations for Stimulating Peripheral Activity to Relieve Conditions (o2S2PARC) has been developed. o2S2PARC enables computational models and analyses to be published as reusable building blocks (‘services’) in larger pipelines and workflows that can be shared and accessed via common web browsers and executed in the cloud. Workflows created by expert modelers can be packaged as easy-to-use applications using o2S2PARC’s ‘Guided Mode’ to provide, for example, a treatment-planning tool that can be used by clinicians with little modeling expertise. Close interaction with other SPARC teams allows continuous adaption of the platform design to facilitate integration and coupling of new models. To date, o 2S2PARC has provided many dozens of services developed by SPARC researchers and SIM-Core to facilitate tasks such as image processing and image-based modeling, mechanistic and data-driven biophysical simulation (electromagnetic, electrophysiology, organ physiology, etc.), training and application of deep neural networks, parameterized modeling, and explorable data analysis and visualization. o2S2PARC provides access to detailed whole-body anatomical models and enables biophysiological simulations within realistic representations of the anatomical environment. The ultimate goal of o2S2PARC is to enable modeling of bioelectronics medicine applications, from device-level physical interactions with the peripheral nervous system/spinal cord through to the resulting therapeutic effects on organ physiology, while also providing advance warning of potential unwanted side effects. Developers benefit from powerful application programming interfaces, e.g., for setting up and running complex simulations using the computational resources provided by SPARC. IT’IS is committed to maintaining the o2S2PARC platform and developing a sustainability plan beyond the SPARC program. In the coming months, the IT’IS team will continue to harden and increase stability and scalability to accommodate increased use. Integration with the SPARC data, maps, and knowledge management will be tightened, and a dedicated effort will be made to increase the attractiveness of o2S2PARC and other SPARC resources to application developers.

NIH记者的O2S2PARC Y6摘要 它是基金会，SIM核 SIM核的使命是确保在SPARC计划下开发的计算模型和分析可访问，可持续保存，可重复使用和互操作。为此，已经开发了一个全面，用户友好的开放平台，用于在线模拟以缓解条件（O2S2PARC）。 O2S2PARC使计算模型和分析能够在较大的管道​​和工作流中以可重复使用的构建块（'Services'）发布，这些块和工作流可以通过常见的Web浏览器共享和访问，并在云中执行。由专家模型创建的工作流可以使用O2S2PARC的“指导模式”作为易于使用的应用程序包装，以提供例如使用少量建模专业知识的临床医生可以使用的治疗计划工具。与其他SPARC团队的密切互动允许对平台设计的持续适应，以促进新型号的集成和耦合。迄今为止，O 2S2PARC为SPARC研究人员和SIM核提供了数十种服务，以促进诸如图像处理和基于图像的建模，机械和数据驱动的生物物理模拟（电磁，电气生理学，组织生理学等），深度神经网络的培训和应用，深度神经网络的培训和应用，可参数化的模型和探索数据分析和探索数据分析和探索。 O2S2PARC提供了详细的全身解剖模型，并在解剖环境的现实表示中启用生物生理模拟。 O2S2PARC的最终目标是实现对生物电子药物应用的建模，从设备水平的物理相互作用与外围神经系统/脊髓/脊髓到对器官生理的治疗作用，同时还提供了预先警告潜在不需要的副作用。开发人员受益于强大的应用程序编程接口，例如，使用SPARC提供的计算资源来设置和运行复杂的模拟。它致力于维护O2S2PARC平台并制定SPARC计划以外的可持续性计划。在接下来的几个月中，IT IS团队将继续硬化并提高稳定性和可扩展性，以适应增加的使用。将收集与SPARC数据，地图和知识管理的集成，并将为提高O2S2PARC和其他SPARC资源对应用程序开发人员的吸引力而做出专门的努力。