IMPROVED SPACIAL LOCALIZATION FOR SPECTROSCOPIC IMAGING

改进光谱成像的空间定位

• 批准号: 7960873
• 负责人: LAWRENCE P PANYCH
• 金额: $ 5.48万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960873
• 关键词: Clinical; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Diagnosis; Diagnostic; Distant; Environment; Extravasation; Feasibility Studies; Funding; Grant; Hemorrhage; Hybrids; Image; Institution; Lipids; Malignant neoplasm of prostate; Measurement; Methods; Modality; Noise; Patients; Process; Prostate; Protons; Recruitment Activity; Research; Research Personnel; Resolution; Resources; Shapes; Signal Transduction; Source; Spectrum Analysis; Time; Training; United States National Institutes of Health; Water; Work; base; cost; data acquisition; flexibility; image guided therapy; improved; in vivo; interest; programs; radiologist; spectroscopic imaging; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Project Summary Grant Number: Project Official Start: 09-MAY-2005 Project Start: 09-MAY-2008 Project End: 28-FEB-2011 In-vivo MR proton spectroscopy has been shown to be clinically valuable for assessing and localizing tumors in the prostate. However, due to the inherently low signal-to-noise ratio (SNR) in MR spectroscopic imaging (MRSI), measurement times can be very long. Thus, to be practical for clinical prostate MRSI, these times must be reduced and spatial resolution is generally very low. A significant problem in MRSI, related to low-resolution data acquisition, is that there can be significant ringing, i.e., a kind of bleeding of signal contamination into the voxel-of-interest, from neighboring and even distant voxels. Contamination from unsuppressed lipid or water signal can be especially problematic, in some cases, rendering prostate spectra useless for diagnosis. A new hybrid spatial encoding method is being developed. The method, called PSF-Choice, maintains the simplicity of standard Fourier encoding while including the flexibility of non-Fourier encoding to shape the point-spread-function (PSF). With this method, practical spectroscopic imaging of the prostate that is free from lipid contamination can be achieved with no additional cost in imaging time or loss in resolution or SNR. Benefits to NCIGT MR spectroscopic imaging is becoming a common modality used in the IGT program for diagnosis of prostate cancer. Unfortunately, as some studies show, the spectra in many voxels of a patient exam are corrupted by lipid leakage and the spectra are not of diagnostic quality. In some patients this may be as many as 90 percent of the voxels. The PSF-Choice offers the possibility of eliminating this kind of contamination and, thus, greatly improving the diagnostic quality of the MRSI exams. The method is being programmed based on the PROSE sequence which is used by other groups for prostate spectroscopy. The benefit to the resource of this collaboration is that, if the project is successful, a much improved spectroscopic sequence will be available to the prostate program and can also be disseminated to external groups. Benefits to the Project The IGT resource provides an essential support to the R21 project. The programming environment for development of the sequence is maintained (in part) through support from the imaging core of the resource. In addition, a training fellow attached to the IGT resource, Joe Roebuck, who is both a radiologist and an spectroscopist, is participating in the experimental work of the R21 project. He is able to give clinical focus to the project as well as expert advice on matters pertaining to spectroscopy - in particular, processing of the spectroscopic data. He has built a prostate spectroscopic phantom for use by the project. Finally, the resource provides an essential clinical environment in which the method developed can be validated. Once technical development is completed, a feasibility study will be conducted using patients recruited through collaborations withing the IGT resource.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 项目概要 拨款编号： 项目正式启动：2005年5月9日 项目启动：2008 年 5 月 9 日 项目结束：2011 年 2 月 28 日 体内磁共振质子光谱已被证明对于评估和定位前列腺肿瘤具有临床价值。然而，由于磁共振光谱成像 (MRSI) 固有的低信噪比 (SNR)，测量时间可能会很长。因此，为了实用于临床前列腺 MRSI，这些时间必须减少，并且空间分辨率通常非常低。 MRSI 中与低分辨率数据采集相关的一个重要问题是，可能会出现明显的振铃，即，信号污染从邻近甚至远处的体素渗入感兴趣的体素。在某些情况下，来自未抑制的脂质或水信号的污染可能尤其成问题，导致前列腺光谱对诊断无用。一种新的混合空间编码方法正在开发中。该方法称为 PSF-Choice，保持了标准傅里叶编码的简单性，同时包含非傅里叶编码的灵活性来塑造点扩散函数 (PSF)。通过这种方法，可以实现不受脂质污染的前列腺的实用光谱成像，而不会增加成像时间的成本或分辨率或信噪比的损失。 对 NCIGT 的好处 MR 光谱成像正在成为 IGT 项目中用于诊断前列腺癌的常用方法。不幸的是，正如一些研究表明的那样，患者检查的许多体素中的光谱因脂质渗漏而被破坏，并且光谱不具有诊断质量。在某些患者中，这可能高达 90% 的体素。 PSF-Choice 提供了消除这种污染的可能性，从而大大提高了 MRSI 检查的诊断质量。该方法是根据其他小组用于前列腺光谱学的 PROSE 序列进行编程的。此次合作的资源优势在于，如果该项目成功，前列腺项目将可以获得大大改进的光谱序列，并且还可以传播给外部团体。 对项目的好处 IGT 资源为 R21 项目提供了必要的支持。用于序列开发的编程环境（部分）通过资源成像核心的支持来维护。此外，IGT资源的培训研究员Joe Roebuck，既是放射科医生又是光谱学家，正在参与R21项目的实验工作。他能够为该项目提供临床重点，并就光谱相关问题（特别是光谱数据的处理）提供专家建议。他建造了一个前列腺光谱模型供该项目使用。最后，该资源提供了一个重要的临床环境，可以在其中验证所开发的方法。一旦技术开发完成，将利用通过 IGT 资源合作招募的患者进行可行性研究。