Validity of DSM-IV Subtypes of ADHD for Young Children

DSM-IV ADHD 亚型对幼儿的有效性

• 批准号: 7669086
• 负责人: Benjamin B Lahey
• 金额: $ 26.09万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-02-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7669086
• 关键词: 18 year old; 6 year old; Accidental Injury; Address; Adolescence; Adolescent; Adopted; Age; Alcohol or Other Drugs use; Anxiety Disorders; Attention deficit hyperactivity disorder; Bipolar Disorder; Characteristics; Child; Child Behavior; Childhood; Classification; Conduct Disorder; Confounding Factors (Epidemiology); DSM-IV; DSM-V; Data; Data Analyses; Decision Making; Development; Diagnosis; Diagnostic; Drops; Ethnic Origin; Evaluation; Exhibits; Funding; Future; Impairment; Intelligence; Learning; Longitudinal Studies; Maps; Measures; Mental Health; Mental disorders; Mind; Modeling; Mood Disorders; Moods; Nursery Schools; Oppositional Defiant Disorder; Outcome; Parenting behavior; Parents; Pattern; Pharmaceutical Preparations; Preschool Child; Prevention; Process; Psychopathology; Psychosocial Factor; Race; Recovery; Reporting; Risk; Sampling; Scheme; Schools; Socioeconomic Status; Structure; Substance abuse problem; Symptoms; Taxonomy; Testing; Time; Unipolar Depression; Ursidae Family; Variant; Youth; base; depression; early childhood; experience; follow-up; functional disability; high risk sexual behavior; improved; parental influence; proband; psychosocial; social; theories; vehicular accident; working group

DESCRIPTION (provided by applicant): In this revised application, we propose to conduct annual assessments through 18 years of age to complete an ongoing longitudinal study of the predictive validity of DSM-IV criteria for attention-deficit/ hyperactivity disorder (ADHD) when it is first diagnosed at 4-6 years of age. It is important to evaluate the predictive validity of ADHD in young children, partly because of the documented increase in the use of psychoactive medications in preschool children. Because all treatments confer some risk, it is essential to know if the DSM-IV criteria for ADHD accurately identify younger children with significant functional impairment and adverse long-term outcomes. The sample consists of 125 ADHD probands and 130 well-matched nonreferred comparison children who are currently being assessed in their tenth annual assessments. In order to inform decision making for DSM-V, we will use the proposed adolescent follow-ups to address the predictive validity of the diagnostic criteria for ADHD, including symptoms and thresholds, the validity of the subtypes of ADHD, and the appropriateness of age-specific symptoms and diagnostic thresholds. The present study has the advantages of using DSM-IV diagnostic criteria and beginning annual structured diagnostic assessments at an early age. When completed, this study will provide the first detailed mapping of the developmental course of DSM-IV ADHD, including developmental progressions from ADHD to other mental health outcomes (conduct problems, unipolar depression, bipolar disorder, anxiety disorders, and substance use) from early childhood through adolescence. Because we expect ADHD probands to exhibit declining average levels of ADHD symptoms over time, we will adopt a developmental approach to predictive validity. That is, we predict that probands whose ADHD symptoms persist into adolescence will be more likely to exhibit impaired functioning and experience other adverse mental health outcomes in adolescence. If this hypothesis is confirmed, as preliminary findings suggest, we will test key hypotheses regarding early child characteristics and potential psychosocial factors that may predict future persistence versus recovery in ADHD symptoms and impairment. Similarly, we will determine if these early child characteristic and psychosocial factors allow differential prediction of other adolescent mental health outcomes. Answering these questions will inform taxonomy, etiologic theory, and assist future efforts at targeted prevention.

描述（由申请人提供）：在本修订后的申请中，我们建议对 18 岁以下儿童进行年度评估，以完成一项持续的纵向研究，该研究涉及 DSM-IV 标准对注意力缺陷/多动障碍 (ADHD) 的预测有效性。首次诊断于 4-6 岁。评估幼儿 ADHD 的预测有效性非常重要，部分原因是学龄前儿童使用精神活性药物的情况有所增加。由于所有治疗都会带来一定的风险，因此有必要了解 DSM-IV 的 ADHD 标准是否能够准确识别患有严重功能障碍和不良长期后果的年幼儿童。该样本由 125 名 ADHD 先证者和 130 名匹配良好的非参考对照儿童组成，他们目前正在第十次年度评估中接受评估。为了为 DSM-V 的决策提供信息，我们将使用拟议的青少年随访来解决 ADHD 诊断标准的预测有效性，包括症状和阈值、ADHD 亚型的有效性以及年龄的适当性-特定症状和诊断阈值。本研究的优点是使用 DSM-IV 诊断标准并在很小的时候就开始每年的结构化诊断评估。完成后，这项研究将首次详细绘制 DSM-IV ADHD 的发展过程，包括从早期 ADHD 到其他心理健康结果（品行问题、单相抑郁、双相情感障碍、焦虑症和物质使用）的发展进展。童年到青春期。因为我们预计 ADHD 先证者的 ADHD 症状平均水平会随着时间的推移而下降，所以我们将采用发展方法来提高预测有效性。也就是说，我们预测，多动症症状持续到青春期的先证者更有可能表现出功能受损，并在青春期经历其他不良的心理健康结果。如果这一假设得到证实，正如初步结果所表明的那样，我们将测试有关早期儿童特征和潜在心理社会因素的关键假设，这些因素可能预测未来多动症症状和障碍的持续与恢复。同样，我们将确定这些早期儿童特征和心理社会因素是否允许对其他青少年心理健康结果进行差异预测。回答这些问题将为分类学、病因学理论提供信息，并有助于未来的有针对性的预防工作。

项目成果

Three-year predictive validity of DSM-IV attention deficit hyperactivity disorder in children diagnosed at 4-6 years of age.

DSM-IV 注意力缺陷多动障碍对 4-6 岁儿童诊断的三年预测有效性。

• 发表时间: 2004-11
• 作者: Lahey, Benjamin B;Pelham, William E;Loney, Jan;Kipp, Heidi;Ehrhardt, Ashley;Lee, Steve S;Willcutt, Erik G;Hartung, Cynthia M;Chronis, Andrea;Massetti, Greta
• 通讯作者: Massetti, Greta

Association of maternal dopamine transporter genotype with negative parenting: evidence for gene x environment interaction with child disruptive behavior.

母亲多巴胺转运蛋白基因型与消极养育的关联：基因x环境与儿童破坏性行为相互作用的证据。

• 发表时间: 2010-05
• 影响因子: 11
• 作者: Lee, S S;Chronis;Keenan, K;Pelham, W E;Loney, J;Van Hulle, C A;Cook, E H;Lahey, B B
• 通讯作者: Lahey, B B

Mother and Adolescent Reports of Interparental Discord among Parents of Adolescents with and without Attention-Deficit Hyperactivity Disorder.

患有和不患有注意力缺陷多动障碍的青少年父母之间父母间不和的母亲和青少年报告。

• 发表时间: 2008-03-01
• 影响因子: 1.9
• 作者: Wymbs, Brian T;Pelham Jr, William E;Gnagy, Elizabeth M;Molina, Brooke S G
• 通讯作者: Molina, Brooke S G

The Effects of Stimulant Medication and Training on Sports Competence Among Children With ADHD.

兴奋剂药物和训练对多动症儿童运动能力的影响。

• 发表时间: 2019
• 作者: Altszuler, Amy R;Morrow, Anne S;Merrill, Brittany M;Bressler, Shannon;Macphee, Fiona L;Gnagy, Elizabeth M;Greiner, Andrew R;Coxe, Stefany;Raiker, Joseph S;Coles, Erika;Pelham Jr, William E
• 通讯作者: Pelham Jr, William E

Maternal depression and early positive parenting predict future conduct problems in young children with attention-deficit/hyperactivity disorder.

母亲抑郁和早期积极养育可以预测患有注意力缺陷/多动障碍的幼儿未来的行为问题。

• DOI: 10.1037/0012-1649.43.1.70
• 发表时间: 2024-09-14
• 期刊: Developmental psychology
• 影响因子: 4
• 作者: Andrea M. Chronis;B. Lahey;W. Pelham;S. H. Williams;Barbara L Baumann;H. Kipp;Heather A Jones;P. Rathouz
• 通讯作者: P. Rathouz