US Hospital Vaccine Effectiveness (VE) Network - Supplement

美国医院疫苗有效性 (VE) 网络 - 补充资料

• 批准号: 10225277
• 负责人: ARNOLD S MONTO
• 金额: $ 70.68万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10225277
• 关键词: US; Hospital; Vaccine; Effectiveness; VE

 DESCRIPTION (provided by applicant): Prevention of hospitalization has long been viewed as a major health benefit of the use of influenza vaccine. This was, in large part, the rationale for the initial vaccination programs targeting the elderly and those with underlying health conditions. However, in the last decade, questions have been raised about the value of such programs. Modern study designs to assess vaccine effectiveness (VE) have required laboratory confirmation of influenza infection, as well as documentation of vaccine receipt and the use of a test-negative design to control for differences in healthcare-seeking behavior between vaccinated and unvaccinated patients. There is a need for current estimates of VE in preventing influenza-associated hospitalization using these methods. We propose estimation of influenza vaccine effectiveness in preventing influenza hospitalization in two health systems in Michigan, where we have been conducting annual assessments of VE in various populations since 2008. We will conduct surveillance at two hospitals, and will enroll adult in-patients with acute respiratory infection. Vaccination status will be reported and documented, and considered with laboratory-confirmed influenza outcomes to estimate vaccine effectiveness for prevention of hospitalization. Analyses will use a test- negative design; those testing positive for influenza ar cases, those testing negative are controls. Modifiers and confounders of vaccine effectiveness such as age, health status, high-risk health conditions, functional status, frailty, education, tim from illness onset to specimen collection, calendar time, and propensity for vaccination will be assessed. In addition to our proposed influenza surveillance and VE assessment, we propose an estimation of the incidence of hospitalization in adults due to respiratory syncytial virus (RSV and other respiratory viruses. This will allow for the evaluation of bias in influenza VE assessment due to interaction between influenza vaccination, infection, and non-influenza respiratory viruses, and will establish a platform for the future evaluation of RSV vaccines. We will accomplish these additional objectives by expanding our surveillance to months before and after the typical influenza season and evaluating specimens by molecular methods for RSV and other respiratory viruses.

 描述（通过应用程序提供）：长期以来，预防住院治疗是使用影响力疫苗的主要健康益处。这在很大程度上是针对老年人和具有潜在健康状况的疫苗计划的初始疫苗计划的基本原理。 但是，在过去的十年中，人们对此类计划的价值提出了问题。评估疫苗有效性（VE）的现代研究设计需要实验室确认影响力感染，以及疫苗收到的记录以及使用测试阴性设计来控制疫苗接种和未接种的患者之间寻求医疗保健行为的差异。使用这些方法，需要对预防影响与影响的住院治疗的当前VE估计。我们提出了在密歇根州的两个卫生系统中预防影响力疫苗的有效性的估计，自2008年以来，我们一直在对各种人群进行年度评估。我们将在两家医院进行监视，并将招募患有急性呼吸道感染的成人患者。将报告和记录疫苗接种状态，并考虑实验室确认的影响力结果，以估计预防住院的疫苗有效性。分析将使用测试负面设计；那些对影响力呈阳性的人，测试阴性的那些是对照。疫苗有效性的修饰符和混杂因素，例如年龄，健康状况，高风险的健康状况，功能状况，脆弱，教育，从疾病发作到标本收集的TIM，日历时间和疫苗的承诺。除了提出的影响力监测和VE评估外，我们还提出了由于呼吸道合胞病毒而导致的成人住院的事件（RSV和其他呼吸道病毒引起的住院事件）。这将允许评估由于影响力和非影响力与不合情步的影响，以及对影响力的相互作用，以及Influe and Infection and Infection，Infection and In-Influe，Infection and In-Influe，Infection and In-In-Influe互相相互作用的偏见，并进行评估。对RSV疫苗的未来评估。

项目成果

Evaluation of correlates of protection against influenza A(H3N2) and A(H1N1)pdm09 infection: Applications to the hospitalized patient population.

评估甲型 (H3N2) 和甲型 (H1N1)pdm09 流感感染防护的相关性：在住院患者群体中的应用。

• DOI: 10.1016/j.vaccine.2019.01.055
• 发表时间: 2019
• 期刊: Vaccine
• 影响因子: 5.5
• 作者: Petrie,JoshuaG;Martin,EmilyT;Truscon,Rachel;Johnson,Emileigh;Cheng,CarolineK;McSpadden,EJ;Malosh,RyanE;Lauring,AdamS;Lamerato,LoisE;Eichelberger,MarynaC;Ferdinands,JillM;Monto,ArnoldS
• 通讯作者: Monto,ArnoldS

Leached Compounds from Smoked Cigarettes and Their Potential for Bioaccumulation in Rainbow Trout (Oncorhynchus mykiss).

• DOI: 10.1021/acs.chemrestox.3c00167
• 发表时间: 2023-11-20
• 期刊: CHEMICAL RESEARCH IN TOXICOLOGY
• 影响因子: 4.1
• 作者: Richardot, William H.;Yabes, Lenard;Wei, Hung-Hsu;Dodder, Nathan G.;Watanabe, Kayo;Cibor, Adrienne;Schick, Suzaynn F.;Novotny, Thomas E.;Gersberg, Richard;Hoh, Eunha
• 通讯作者: Hoh, Eunha

Severe morbidity among hospitalised adults with acute influenza and other respiratory infections: 2014-2015 and 2015-2016.

• DOI: 10.1017/s0950268818001486
• 发表时间: 2018-08
• 期刊: Epidemiology and infection
• 影响因子: 4.2
• 作者: Segaloff HE;Petrie JG;Malosh RE;Cheng CK;McSpadden EJ;Ferdinands JM;Lamerato L;Lauring AS;Monto AS;Martin ET
• 通讯作者: Martin ET