US Hospital Vaccine Effectiveness (VE) Network - Supplement

美国医院疫苗有效性 (VE) 网络 - 补充资料

• 批准号: 10225277
• 负责人: ARNOLD S MONTO
• 金额: $ 70.68万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10225277
• 关键词: US; Hospital; Vaccine; Effectiveness; VE

 DESCRIPTION (provided by applicant): Prevention of hospitalization has long been viewed as a major health benefit of the use of influenza vaccine. This was, in large part, the rationale for the initial vaccination programs targeting the elderly and those with underlying health conditions. However, in the last decade, questions have been raised about the value of such programs. Modern study designs to assess vaccine effectiveness (VE) have required laboratory confirmation of influenza infection, as well as documentation of vaccine receipt and the use of a test-negative design to control for differences in healthcare-seeking behavior between vaccinated and unvaccinated patients. There is a need for current estimates of VE in preventing influenza-associated hospitalization using these methods. We propose estimation of influenza vaccine effectiveness in preventing influenza hospitalization in two health systems in Michigan, where we have been conducting annual assessments of VE in various populations since 2008. We will conduct surveillance at two hospitals, and will enroll adult in-patients with acute respiratory infection. Vaccination status will be reported and documented, and considered with laboratory-confirmed influenza outcomes to estimate vaccine effectiveness for prevention of hospitalization. Analyses will use a test- negative design; those testing positive for influenza ar cases, those testing negative are controls. Modifiers and confounders of vaccine effectiveness such as age, health status, high-risk health conditions, functional status, frailty, education, tim from illness onset to specimen collection, calendar time, and propensity for vaccination will be assessed. In addition to our proposed influenza surveillance and VE assessment, we propose an estimation of the incidence of hospitalization in adults due to respiratory syncytial virus (RSV and other respiratory viruses. This will allow for the evaluation of bias in influenza VE assessment due to interaction between influenza vaccination, infection, and non-influenza respiratory viruses, and will establish a platform for the future evaluation of RSV vaccines. We will accomplish these additional objectives by expanding our surveillance to months before and after the typical influenza season and evaluating specimens by molecular methods for RSV and other respiratory viruses.

 描述（由申请人提供）：长期以来，预防住院一直被视为使用流感疫苗的主要健康益处，这在很大程度上是针对老年人和有基础健康状况的人的初始疫苗接种计划的基本原理。 然而，在过去十年中，人们对此类计划的价值提出了质疑，以评估疫苗有效性（VE）的现代研究设计需要实验室确认流感感染，以及疫苗接收和测试使用的记录。阴性设计来控制流感患者和未接种疫苗的患者之间就医行为的差异。目前需要使用这些方法来估计 VE 在预防流感相关住院方面的效果。我们估计了两个卫生系统中流感疫苗在预防流感住院方面的有效性。密歇根州，我们一直在那里进行年度评估自 2008 年以来，我们将在两家医院进行监测，并招募患有急性呼吸道感染的成年住院患者，报告和记录疫苗接种情况，并考虑实验室确认的流感结果​​，以评估疫苗预防的有效性。分析将使用测试阴性设计；那些测试呈阴性的流感病例是疫苗有效性的修饰因素和混杂因素，例如年龄、健康状况、高风险健康状况、功能状态。除了我们提出的流感监测和 VE 评估之外，我们还将评估成人因呼吸道合胞病毒而住院的发生率。 （RSV和其他呼吸道病毒。这将允许评估由于流感疫苗接种、感染和非流感呼吸道病毒之间的相互作用而导致的流感VE评估中的偏差，并将为RSV疫苗的未来评估建立一个平台。我们将完成这些额外的通过将我们的监测范围扩大到典型流感季节前后的几个月，并通过分子方法评估标本中 RSV 和其他呼吸道病毒的情况，来实现这一目标。

项目成果

Evaluation of correlates of protection against influenza A(H3N2) and A(H1N1)pdm09 infection: Applications to the hospitalized patient population.

评估甲型 (H3N2) 和甲型 (H1N1)pdm09 流感感染防护的相关性：在住院患者群体中的应用。

• DOI: 10.1016/j.vaccine.2019.01.055
• 发表时间: 2019
• 期刊: Vaccine
• 影响因子: 5.5
• 作者: Petrie,JoshuaG;Martin,EmilyT;Truscon,Rachel;Johnson,Emileigh;Cheng,CarolineK;McSpadden,EJ;Malosh,RyanE;Lauring,AdamS;Lamerato,LoisE;Eichelberger,MarynaC;Ferdinands,JillM;Monto,ArnoldS
• 通讯作者: Monto,ArnoldS

Leached Compounds from Smoked Cigarettes and Their Potential for Bioaccumulation in Rainbow Trout (Oncorhynchus mykiss).

• DOI: 10.1021/acs.chemrestox.3c00167
• 发表时间: 2023-11-20
• 期刊: CHEMICAL RESEARCH IN TOXICOLOGY
• 影响因子: 4.1
• 作者: Richardot, William H.;Yabes, Lenard;Wei, Hung-Hsu;Dodder, Nathan G.;Watanabe, Kayo;Cibor, Adrienne;Schick, Suzaynn F.;Novotny, Thomas E.;Gersberg, Richard;Hoh, Eunha
• 通讯作者: Hoh, Eunha

Severe morbidity among hospitalised adults with acute influenza and other respiratory infections: 2014-2015 and 2015-2016.

• DOI: 10.1017/s0950268818001486
• 发表时间: 2018-08
• 期刊: Epidemiology and infection
• 影响因子: 4.2
• 作者: Segaloff HE;Petrie JG;Malosh RE;Cheng CK;McSpadden EJ;Ferdinands JM;Lamerato L;Lauring AS;Monto AS;Martin ET
• 通讯作者: Martin ET