Predicting and Preventing High-Risk Adolescent Behavior

预测和预防高风险青少年行为

• 批准号: 10116172
• 负责人: Jennifer Suor
• 金额: $ 6.94万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10116172
• 关键词: 16 year old; 19 year old; Address; Adolescence; Adolescent; Adolescent Risk Behavior; Affect; Age; Alcohol consumption; Annual Reports; Area; Biosocial; Characteristics; Chicago; Child; Child Rearing; Childhood; Chronic; Coupled; Development; Electroencephalogram; Electroencephalography; Enrollment; Ensure; Environment; Event-Related Potentials; Exhibits; Exposure to; Family; Feedback; Female; Female Adolescents; Future; Goals; Health; Health behavior outcomes; Hyperphagia; Illinois; Individual; Individual Differences; Infertility; Interpersonal Relations; Knowledge; Lead; Link; Major Depressive Disorder; Mental Depression; Mental Health; Mentors; Methodology; Methods; Monitor; Mothers; Multiple Partners; Nature; Neurosciences Research; Outcome; Parents; Participant; Pathway interactions; Patient Self-Report; Pattern; Persons; Pharmaceutical Preparations; Pregnancy in Adolescence; Prevention strategy; Preventive Intervention; Process; Psychiatry; Psychopathology; Public Health; Qualifying; Recording of previous events; Recurrence; Reporting; Research; Rewards; Risk; Risk Behaviors; Risk Factors; Risk Marker; Risk Reduction; Role; Sampling; Sexually Transmitted Diseases; Smoking; Taxonomy; Testing; Time; Training; Translating; Universities; Ventral Striatum; Vulnerable Populations; Work; Youth; adolescent health; adolescent sexual behavior; affective neuroscience; base; brain behavior; collaborative environment; condoms; cost effective; cost efficient; design; experience; girls; high risk; high risk sexual behavior; high-risk adolescents; implementation science; improved; informant; innovation; intergenerational; longitudinal analysis; maternal depression; neuroimaging; neuromechanism; prevent; programs; prospective; racial and ethnic; racial diversity; recruit; recurrent depression; relating to nervous system; response; reward processing; sex; sexual HIV transmission; sexual debut; sexual risk taking; sexually active; statistics; teenage parents; theories; transmission process; unintended pregnancy

Project Abstract Risky sexual behavior (RSB) (i.e., inconsistent condom use, multiple partners, sex while using alcohol or drugs) increases chances of sexually transmitted infections (STI) and unintended pregnancy. Girls are disproportionately affected; each year one in four sexually active 15-19 year-old females in the U.S. are estimated to have an STI and 15% experience unintended pregnancies. Understanding the mechanisms that place some girls at greater risk for engaging in RSB is crucial for reducing the public health burden of STIs and teenage pregnancy. Reward processing and maternal parenting predict adolescent girls' RSB, but how they interact is unknown. Maternal history of depression also predicts adolescent RSB, likely via its negative impact on parenting. Elucidating interactions between neural risk factors and family contextual processes could lead to innovative, personalized preventative interventions that disrupt patterns of RSB before they become engrained. In the current F32 application, the candidate seeks to address the following aims in a yet to be enrolled, subsample (n = 80) of 12-16 year-old adolescents girls and their mothers, recruited as part of an ongoing study of the intergenerational transmission of major depressive disorder (MDD) (K23MH113793). Half of the mothers (n = 40) will have histories of recurrent MDD and half will have no history of psychopathology (n = 40). The candidate proposes to utilize cost-efficient event-related potentials (ERP), derived from electroencephalogram (EEG), to identify whether greater neural reward responsiveness predicts girls' RSB over 18 months (AIM 1). The candidate will also delineate if maternal parenting moderates effects (AIM 2). The high-risk design of the sample will ensure adequate variability in parenting and adolescent RSB. The candidate seeks to build upon her strong background in developmental psychopathology and biosocial interactions in childhood by gaining new training in: 1) adolescent health-risk behaviors and mental health; 2) developmental affective neuroscience and EEG/ERP methodology; and 3) advanced longitudinal statistics. Training will occur in an outstanding and unique interdisciplinary environment at the University of Illinois at Chicago. She will jointly train in the newly established Center for Dissemination and Implementation Science and in the Department of Psychiatry, which has a strong tradition of affective neuroscience research. The candidate's mentors Drs. Donenberg, Burkhouse, Shankman, Bhaumik have expertise in adolescent health risk behaviors and mental health, developmental affective neuroscience methods (e.g., EEG/ERP), longitudinal high-risk designs, and advanced longitudinal analysis. The proposed study will inform the design of future projects examining whether neural and family mechanisms of risk can be synergistically targeted within personalized HIV/STI risk reduction programs. Accomplishing the study and training goals will allow the candidate to build an independent program of research focused on improving health and behavior outcomes for youth living in high-risk environments.

项目摘要 有风险的性行为（RSB）（即使用避孕套不一致，多个合作伙伴，在使用酒精或 药物）增加了性传播感染（STI）和意外怀孕的机会。女孩是 受到不成比例的影响；每年，美国四分之一的15-19岁女性在美国 据估计患有性病，15％的人经历了意外怀孕。了解该机制 将一些女孩冒着参与RSB的风险更大，对于减轻性传播疾病的公共卫生负担至关重要 青少年怀孕。奖励加工和母性育儿可以预测青春期女孩的RSB，但如何 互动是未知的。抑郁症的孕产妇病史还可以预测青少年RSB，这可能是通过其负面影响 关于育儿。阐明神经风险因素与家庭背景过程之间的相互作用可能导致 创新，个性化的预防性干预措施，在RSB受到根深蒂固之前破坏了RSB的模式。 在当前的F32申请中，候选人试图解决以下目的，以注册尚未注册， 12-16岁的青少年女孩及其母亲的子样本（n = 80），作为正在进行的研究的一部分 主要抑郁症（MDD）的代际传播（K23MH113793）。一半的母亲 （n = 40）将具有复发性MDD的历史，一半将没有精神病理学史（n = 40）。这 候选人建议利用源自脑电图的成本效益与事件相关电位（ERP） （EEG），确定更大的神经奖励反应能力是否可以预测18个月内女孩的RSB（AIM 1）。 如果孕产妇的育儿调节效果，候选人也将描述（AIM 2）。高风险的设计 样本将确保育儿和青少年RSB的适当变化。候选人试图以 她在童年时期的发育心理病理学和生物社会相互作用方面有着强大的背景 新培训：1）青少年健康风险行为和心理健康； 2）发展情感 神经科学和EEG/ERP方法论； 3）高级纵向统计。培训将在 伊利诺伊大学芝加哥大学的杰出而独特的跨学科环境。她将共同训练 在新成立的传播与实施科学中心以及部门 精神病学，具有强烈的情感神经科学研究传统。候选人的导师博士。 Donenberg，Burkhouse，Shankman，Bhaumik在青少年健康风险行为和心理方面具有专业知识 健康，发展性情感神经科学方法（例如，脑电图/ERP），纵向高危设计和 晚期纵向分析。拟议的研究将告知未来项目的设计，以研究是否 风险的神经和家庭机制可以在个性化的HIV/STI风险降低中协同针对 程序。完成研究和培训目标将使候选人能够建立一个独立的计划 研究重点是改善生活在高风险环境中的青年的健康和行为成果。