Predicting and Preventing High-Risk Adolescent Behavior

预测和预防高风险青少年行为

• 批准号: 10116172
• 负责人: Jennifer Suor
• 金额: $ 6.94万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10116172
• 关键词: 16 year old; 19 year old; Address; Adolescence; Adolescent; Adolescent Risk Behavior; Affect; Age; Alcohol consumption; Annual Reports; Area; Biosocial; Characteristics; Chicago; Child; Child Rearing; Childhood; Chronic; Coupled; Development; Electroencephalogram; Electroencephalography; Enrollment; Ensure; Environment; Event-Related Potentials; Exhibits; Exposure to; Family; Feedback; Female; Female Adolescents; Future; Goals; Health; Health behavior outcomes; Hyperphagia; Illinois; Individual; Individual Differences; Infertility; Interpersonal Relations; Knowledge; Lead; Link; Major Depressive Disorder; Mental Depression; Mental Health; Mentors; Methodology; Methods; Monitor; Mothers; Multiple Partners; Nature; Neurosciences Research; Outcome; Parents; Participant; Pathway interactions; Patient Self-Report; Pattern; Persons; Pharmaceutical Preparations; Pregnancy in Adolescence; Prevention strategy; Preventive Intervention; Process; Psychiatry; Psychopathology; Public Health; Qualifying; Recording of previous events; Recurrence; Reporting; Research; Rewards; Risk; Risk Behaviors; Risk Factors; Risk Marker; Risk Reduction; Role; Sampling; Sexually Transmitted Diseases; Smoking; Taxonomy; Testing; Time; Training; Translating; Universities; Ventral Striatum; Vulnerable Populations; Work; Youth; adolescent health; adolescent sexual behavior; affective neuroscience; base; brain behavior; collaborative environment; condoms; cost effective; cost efficient; design; experience; girls; high risk; high risk sexual behavior; high-risk adolescents; implementation science; improved; informant; innovation; intergenerational; longitudinal analysis; maternal depression; neuroimaging; neuromechanism; prevent; programs; prospective; racial and ethnic; racial diversity; recruit; recurrent depression; relating to nervous system; response; reward processing; sex; sexual HIV transmission; sexual debut; sexual risk taking; sexually active; statistics; teenage parents; theories; transmission process; unintended pregnancy

Project Abstract Risky sexual behavior (RSB) (i.e., inconsistent condom use, multiple partners, sex while using alcohol or drugs) increases chances of sexually transmitted infections (STI) and unintended pregnancy. Girls are disproportionately affected; each year one in four sexually active 15-19 year-old females in the U.S. are estimated to have an STI and 15% experience unintended pregnancies. Understanding the mechanisms that place some girls at greater risk for engaging in RSB is crucial for reducing the public health burden of STIs and teenage pregnancy. Reward processing and maternal parenting predict adolescent girls' RSB, but how they interact is unknown. Maternal history of depression also predicts adolescent RSB, likely via its negative impact on parenting. Elucidating interactions between neural risk factors and family contextual processes could lead to innovative, personalized preventative interventions that disrupt patterns of RSB before they become engrained. In the current F32 application, the candidate seeks to address the following aims in a yet to be enrolled, subsample (n = 80) of 12-16 year-old adolescents girls and their mothers, recruited as part of an ongoing study of the intergenerational transmission of major depressive disorder (MDD) (K23MH113793). Half of the mothers (n = 40) will have histories of recurrent MDD and half will have no history of psychopathology (n = 40). The candidate proposes to utilize cost-efficient event-related potentials (ERP), derived from electroencephalogram (EEG), to identify whether greater neural reward responsiveness predicts girls' RSB over 18 months (AIM 1). The candidate will also delineate if maternal parenting moderates effects (AIM 2). The high-risk design of the sample will ensure adequate variability in parenting and adolescent RSB. The candidate seeks to build upon her strong background in developmental psychopathology and biosocial interactions in childhood by gaining new training in: 1) adolescent health-risk behaviors and mental health; 2) developmental affective neuroscience and EEG/ERP methodology; and 3) advanced longitudinal statistics. Training will occur in an outstanding and unique interdisciplinary environment at the University of Illinois at Chicago. She will jointly train in the newly established Center for Dissemination and Implementation Science and in the Department of Psychiatry, which has a strong tradition of affective neuroscience research. The candidate's mentors Drs. Donenberg, Burkhouse, Shankman, Bhaumik have expertise in adolescent health risk behaviors and mental health, developmental affective neuroscience methods (e.g., EEG/ERP), longitudinal high-risk designs, and advanced longitudinal analysis. The proposed study will inform the design of future projects examining whether neural and family mechanisms of risk can be synergistically targeted within personalized HIV/STI risk reduction programs. Accomplishing the study and training goals will allow the candidate to build an independent program of research focused on improving health and behavior outcomes for youth living in high-risk environments.

项目摘要 危险性行为 (RSB)（即，不一致地使用安全套、多个伴侣、饮酒或饮酒时发生性行为） 药物）会增加性传播感染 (STI) 和意外怀孕的机会。女孩们是 受到不成比例的影响；在美国，每年有四分之一的性活跃的 15-19 岁女性 据估计，有 15% 的人患有性传播感染，并且经历过意外怀孕。了解其中的机制 让一些女孩面临更大的参与 RSB 的风险对于减轻性传播感染的公共卫生负担至关重要 少女怀孕。奖励处理和母亲养育可以预测青春期女孩的 RSB，但它们如何预测 相互作用未知。母亲的抑郁史也可能通过其负面影响来预测青少年 RSB 关于育儿。阐明神经风险因素和家庭背景过程之间的相互作用可能会导致 创新的、个性化的预防性干预措施，在 RSB 模式变得根深蒂固之前扰乱它们。 在当前的 F32 申请中，候选人寻求在尚未注册的情况下实现以下目标， 作为一项正在进行的研究的一部分而招募的 12-16 岁少女及其母亲的子样本 (n = 80) 重度抑郁症 (MDD) 的代际传播 (K23MH113793)。一半的妈妈 (n = 40) 有复发性 MDD 病史，一半人没有精神病理学病史 (n = 40)。这 候选人建议利用源自脑电图的经济高效的事件相关电位 (ERP) (EEG)，以确定更大的神经奖赏反应是否可以预测女孩在 18 个月内的 RSB (AIM 1)。 候选人还将描述母性养育是否会减轻影响（AIM 2）。高风险的设计 样本将确保育儿和青少年 RSB 具有足够的可变性。候选人寻求建立在 她在儿童时期的发展精神病理学和生物社会互动方面拥有深厚的背景 新培训涉及：1）青少年健康风险行为和心理健康； 2）发展情感 神经科学和 EEG/ERP 方法； 3）高级纵向统计。培训将在 伊利诺伊大学芝加哥分校拥有出色且独特的跨学科环境。她将联合训练 在新成立的传播和实施科学中心以及科学系 精神病学具有深厚的情感神经科学研究传统。候选人的导师博士。 Donenberg、Burkhouse、Shankman、Bhaumik 拥有青少年健康风险行为和心理方面的专业知识 健康、发育情感神经科学方法（例如 EEG/ERP）、纵向高风险设计，以及 高级纵向分析。拟议的研究将为未来项目的设计提供信息，以检验是否 神经和家庭风险机制可以在个性化艾滋病毒/性传播感染风险降低中协同作用 程序。完成学习和培训目标将使候选人能够建立独立的计划 的研究重点是改善生活在高风险环境中的青少年的健康和行为结果。