Center for Engineering Complex Tissues

复杂组织工程中心

• 批准号: 10113608
• 负责人: John P Fisher
• 金额: $ 112.61万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-15 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10113608
• 关键词: 3D Print; Address; Advisory Committees; Area; Award; Back; Biocompatible Materials; Biomedical Engineering; Biomedical Technology; Bioreactors; Bone Tissue; Cardiac; Cartilage; Cell Culture Techniques; Cell Survival; Cells; Cellularity; Clinical; Collaborations; Communication Programs; Communities; Complex; Development; Device or Instrument Development; Education; Educational workshop; Encapsulated; Engineering; Ensure; Event; Formulation; Fostering; Funding; Goals; Infrastructure; Institution; International; Joints; Lead; Leadership; Maryland; Pattern; Phase; Population; Positioning Attribute; Productivity; Property; Publications; Regenerative Medicine; Research; Research Personnel; Resources; Rice; Series; Services; Technology; Tissue Engineering; Tissues; Training; Transplantation; Universities; Work; base; biofabrication; bioprinting; career; clinically relevant; experience; forest; implantation; improved; innovation; knowledge base; new technology; next generation; novel; novel strategies; operation; osteochondral tissue; outreach; programs; recruit; scaffold; sound; success; technology research and development; tool; undergraduate student; urologic; 3D Print; Address; Advisory Committees; Area; Award; Back; Biocompatible Materials; Biomedical Engineering; Biomedical Technology; Bioreactors; Bone Tissue; Cardiac; Cartilage; Cell Culture Techniques; Cell Survival; Cells; Cellularity; Clinical; Collaborations; Communication Programs; Communities; Complex; Development; Device or Instrument Development; Education; Educational workshop; Encapsulated; Engineering; Ensure; Event; Formulation; Fostering; Funding; Goals; Infrastructure; Institution; International; Joints; Lead; Leadership; Maryland; Pattern; Phase; Population; Positioning Attribute; Productivity; Property; Publications; Regenerative Medicine; Research; Research Personnel; Resources; Rice; Series; Services; Technology; Tissue Engineering; Tissues; Training; Transplantation; Universities; Work; base; biofabrication; bioprinting; career; clinically relevant; experience; forest; implantation; improved; innovation; knowledge base; new technology; next generation; novel; novel strategies; operation; osteochondral tissue; outreach; programs; recruit; scaffold; sound; success; technology research and development; tool; undergraduate student; urologic

Project Summary The fabrication of complex engineered tissues remains a grand challenge in regenerative medicine. These complex tissues – bone, cartilage, vasculature, and cardiac – are characterized by dense cellularity, patterned cellular composition, and controlled matrix presentation. The proposed Biomedical Technology Resource Center (BTRC) will address this critical need by applying three-dimensional printing (3DP) strategies to the engineering of complex tissues. This BTRC brings together research leaders at the University of Maryland, Rice University, and Wake Forest University, all highly regarded collaborators in the field, to lead the development of the Center for Engineering Complex Tissues (CECT, [sees-t]). Strong and effective administrative leadership will maximize productivity, enhance ongoing collaborations, and ensure sound fiscal and compliance management for this BTRC. The technical components of CECT consist of 3 Technology Research and Development Projects (TR&Ds), 6 Collaborative Projects (CPs), and 6 Service Projects (SPs). An External Advisory Committee (EAC), that will guide and advise the strategic direction of the Center, will be assembled from world-renowned researchers with biomedical expertise relevant to the CECT. A Local Executive Committee (LEC) will coordinate the effort across the participating institutions involved in the day-to- day operations of the Center. We will also focus on growing a community engaged in developing and utilizing complex engineered tissues by offering a series of programs to help develop and establish these technologies. Communications programs will also be developed for the dissemination of the Center’s activities to enable a broader use of the technologies. The long-term plan for the CECT is that it will become a national hub for transforming current 3DP and tissue engineering technologies into new and improved platforms for everyday uses in regenerative medicine and biomedical device development.

项目摘要 复杂工程组织的制造仍然是再生医学中的巨大挑战。这些 复杂的组织 - 骨骼，软骨，脉管系统和心脏 - 具有密集的细胞，图案化的特征 细胞组成和受控矩阵表现。拟议的生物医学技术资源 中心（BTRC）将通过将三维印刷（3DP）策略应用于 复杂组织的工程。这个BTRC汇集了马里兰大学的研究领袖 莱斯大学和韦克森林大学（Wake Forest University）都是该领域备受推崇的合作者 开发工程复杂组织中心（CECT，[SEES-T]）。强大而有效 行政领导将最大化生产率，提高持续的合作并确保合理的财政 和此BTRC的合规管理。 CECT的技术组成部分由3个技术组成 研发项目（TR＆D），6个协作项目（CPS）和6个服务项目（SPS）。 将指导和建议该中心的战略方向的外部咨询委员会（EAC）将是 由世界知名的研究人员组成，具有与CECT相关的生物医学专业知识。本地 执行委员会（LEC）将协调参与日常参与机构的努力 中心的日间操作。我们还将专注于发展一个从事发展和使用的社区 通过提供一系列计划来帮助开发和建立这些技术，复杂的工程组织。 还将开发通讯计划，以传播该中心的活动，以使 更广泛的技术使用。 CECT的长期计划是它将成为国家枢纽 每天将当前的3DP和组织工程技术转换为新的和改进的平台 在再生医学和生物医学装置开发中的用途。