Healthy Aging: an EEG-based wearable device to accurately monitor sleep and enhance quality for improved cognitive functioning

健康老龄化：基于脑电图的可穿戴设备，可准确监测睡眠并提高质量，从而改善认知功能

• 批准号: 10076067
• 负责人: Giovanni Santostasi
• 金额: $ 22.29万
• 依托单位: DEEPWAVE TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10076067
• 关键词: Acoustic Stimulation; Adult; Age of Onset; Age-associated memory impairment; Aging; Algorithms; Alzheimer' s Disease; American; Amyloid beta-Protein; Brain; Caring; Classification; Cognitive; Cost aspects; Coupled; Dementia; Devices; Disease; Economic Burden; Elderly; Electrodes; Electroencephalogram; Ensure; Environment; Feedback; Funding; Goals; Home environment; Impaired cognition; Individual; Intervention; Laboratories; Legal patent; Life Expectancy; Link; Medical Device; Memory; Miniaturization; Monitor; Nerve Degeneration; Neurocognitive; Neurodegenerative Disorders; Outcome; Participant; Patients; Perception; Performance; Persons; Phase; Play; Polysomnography; Process; Questionnaires; Research; Risk Factors; Role; Running; Sensitivity and Specificity; Signal Transduction; Sleep; Slow-Wave Sleep; Small Business Innovation Research Grant; System; Technology; Testing; Time; Treatment Protocols; age related; aged; base; clinical practice; cognitive function; cognitive training; design; drug development; effective therapy; experience; healthy aging; improved; improvement on sleep; innovation; innovative technologies; instrumentation; laboratory equipment; mild cognitive impairment; modifiable risk; phase 1 study; placebo group; prevent; programs; prototype; signal processing; sleep pattern; sleep quality; treatment group; usability; volunteer; wearable device

PROJECT SUMMARY More than 40% of individuals as young as 60 start to experience some sort of cognitive decline. Among these, nearly one person in five develops mild cognitive impairment (MCI), a potential precursor of severe neurodegenerative diseases, like Alzheimer’s Disease (AD) and dementia. Today, AD and dementia represent an economic burden of $277 B/year in the U.S. alone. Nothing can be done to cure or slow down them and drug development has failed so far - big pharma companies are quitting research in this field. Notwithstanding, life expectancy is rising. By 2050 the number of dementia cases will triple, and 13.2 million Americans will live with AD. Therefore, finding alternative interventions to slow down cognitive decline is an urgent priority and a necessary answer to an unmet need. Age-related decline in memory performance has been linked to the age-related reduction of deep sleep, or Slow Wave sleep (SWS). Interestingly, this represents a modifiable risk factor for cognitive decline. We previously demonstrated the ability to enhance declarative memory in older adults by manipulating SWS for one night, in a laboratory environment, through non-invasive acoustic stimulation. The key is in the timing of acoustic stimulation, which is based on real-time analysis of EEG signal and aims at amplifying the single slow wave. However, it must be verified whether this acoustic stimulation can be comfortably tolerated when administered for many consecutive nights and whether memory enhancement shows a cumulative effect. To this extent, with this SBIR phase I project, we plan to bring our technology from the laboratory environment to the home-base settings. In particular, we aim to 1) Realize and validate a wearable headband, suitable for at-home-use, capable to detect the SWS upstate from EEG signal in real-time, and to deliver, accordingly, an acoustic stimulation. 2) Test user experience of the new device in healthy and MCI adults aged 60 and older. 3) Examine cumulative memory enhancement in these subjects upon delivery of acoustic stimulation for 7 consecutive nights. The successful outcomes of this project will open the way to the realization of the first wearable for cognitive training, based on safe manipulation of sleep via EEG-controlled acoustic stimulation. By improving memory performance during sleep, the proposed approach has the potential to dramatically delay or prevent the onset of age-related cognitive decline. In the long run, the benefit of our system may be further extended to slowing down progression of neurodegenerative disorders such AD and dementia.

项目概要 超过 40% 的人在 60 岁时就开始出现某种程度的认知能力下降。 近五分之一的人患有轻度认知障碍 (MCI)，这是严重认知障碍的潜在前兆 神经退行性疾病，如阿尔茨海默病 (AD) 和痴呆症。 如今，AD 和痴呆症代表 的经济负担 仅在美国就花费 277 美元/年，没有什么可以治愈或减缓这些疾病和药物。 迄今为止，开发已经失败——大型制药公司正在放弃这一领域的研究。 到 2050 年，痴呆症病例数量将增加两倍，1320 万美国人将患有痴呆症。 因此，寻找替代干预措施来减缓认知能力下降是当务之急。 与年龄相关的记忆力下降与未满足的需求有关。 与年龄相关的深度睡眠或慢波睡眠（SWS）减少。 我们之前证明了增强老年人陈述性记忆的能力。 通过在实验室环境中通过非侵入性声刺激操纵 SWS 一晚。 关键在于声刺激的时机，它基于脑电信号的实时分析，旨在 放大单个慢波但是，必须验证这种声刺激是否可以。 连续多晚服用后可以轻松耐受，并且记忆力是否增强 从这个意义上说，通过这个 SBIR 第一阶段项目，我们计划将我们的技术从 特别是，我们的目标是 1) 实现并验证可穿戴设备。 头带，适合家庭使用，能够实时检测脑电信号中的SWS上状态，并 2) 在健康和 MCI 成人中测试新设备的用户体验 60 岁及以上 3) 检查这些受试者在接受声学训练后的累积记忆增强情况。 连续7晚的刺激，将为该项目的成功开启道路。 首款用于认知训练的可穿戴设备，基于通过脑电图控制的声波安全操纵睡眠 通过改善睡眠期间的记忆表现，所提出的方法有可能 从长远来看，我们的系统将受益匪浅。 可能进一步扩展到减缓神经退行性疾病（如 AD 和痴呆）的进展。