Mechanisms of Sensory Processing in Fibromyalgia
纤维肌痛的感觉处理机制
基本信息
- 批准号:7683171
- 负责人:
- 金额:$ 41.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-09-05 至 2013-03-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAcoustic StimulationAddressAffectiveAnteriorAuditoryBehavioralBrainBrain imagingBreathingC FiberCarbon DioxideCategoriesCharacteristicsCognitiveDataDetectionDevelopmentDiagnosisDiagnosticDiscriminationDiseaseDistressElectroencephalographyElementsEmotionsEsthesiaEvaluationEvoked PotentialsFeelingFibromyalgiaFunctional Magnetic Resonance ImagingFutureGeneticGenotypeGoalsHeatingHomeostasisHungerHyperalgesiaIndividualInvestigationIrritable Bowel SyndromeKnowledgeLeadLiteratureLongitudinal StudiesLoudnessLow Back PainMeasuresMechanicsMediatingMethodologyMethodsModalityMoodsNatureNociceptionNociceptive StimulusNociceptorsNoiseOutcome StudyPainPainlessPatientsPatternPerformancePhenotypePhysiologicalPredisposing FactorProbabilityProceduresProcessPsychophysiologyPublishingReaction TimeRegulationRelative (related person)ReportingResearchRisk FactorsRisk MarkerRoleSensorySensory ProcessSomatosensory CortexSpecific qualifier valueStimulusSymptomsSystemTechniquesTemperatureTestingThirstWorkbasebehavior measurementchronic paincingulate cortexclinical practicedesignemotional distressexperiencehealth economicshedonicimprovedinnovationmotivated behaviorneuroimagingpressurepsychological distressresearch studyresponseresponse markersensory discriminationtooltreatment response
项目摘要
DESCRIPTION (provided by applicant): Fibromyalgia is characterized by symptoms of widespread pain and increased sensitivity to painful and non-painful sensory stimulation. The pattern of sensory modality sensitivity varies across individuals. This variance may be due to the contribution of non-sensory factors, especially the unpleasant affective components that motivate behaviors of escape and avoidance. The relative contribution of these elements to altered sensory processing of painful and non-painful stimuli is not known and may account for the limited characterization of the underlying mechanisms of fibromyalgia. The proposed work will identify the role of mechanisms mediating feelings of distress and discomfort in patients with fibromyalgia. The methods use psychophysical multi-method techniques (aim 1), behavioral measures of discrimination performance and aversiveness (aim 2), and functional neuro-imagining (aim 3) to characterize common mechanisms of intensity and affective processing in fibromyalgia and healthy controls, and to characterize the role of brain processing regions implicated in sensory discriminative (primary and secondary somatosensory cortex) and affective (insular and anterior cingulate cortex) processing. The specific psychophysical procedures reduce spurious correlations between intensity and unpleasantness responses. These procedures and behavioral evaluation of discrimination performance and relative and absolute aversiveness will determine the contributions of increased sensory gain and central affective gain in two nociceptive (heat, pressure) and one non-nociceptive stimulus modality (audition) to the symptoms of fibromyalgia and compares these to responses from healthy control subjects. Fibromyalgia is a significant health and economic problem mediated by unknown mechanisms. Current treatments are only marginally effective. Once the mechanisms that initiate and maintain fibromyalgia are understood, this knowledge can be applied to the development of effective rational treatments. We expect that the proposed investigation of altered sensory processing will uncover important information that will significantly advance understanding of the underlying mechanisms. Such an advance is significant since it will guide further investigations of treatments. We expect these results to apply to multiple diagnostic categories and greatly increase the understanding and treatment fibromyalgia and related disorders. PROJECT NARRATIVE: This research will improve the understanding of the underlying mechanisms of fibromyalgia. A better understanding of mechanisms and pain processes will lead to improved therapies and better detection of who will respond to certain types of therapies. The outcomes of this study will also provide better information about phenotypic characteristics that will be useful in guiding future genetic studies.
描述(由申请人提供):纤维肌痛的特征是广泛的疼痛症状以及对疼痛和非疼痛感觉刺激的敏感性增加。感觉形态敏感性的模式因人而异。这种差异可能是由于非感觉因素的贡献,特别是激发逃避和回避行为的不愉快的情感成分。这些元素对改变疼痛和非疼痛刺激的感觉处理的相对贡献尚不清楚,并且可能解释了纤维肌痛潜在机制的有限特征。拟议的工作将确定调节纤维肌痛患者痛苦和不适感的机制的作用。这些方法使用心理物理学多方法技术(目标 1)、辨别表现和厌恶的行为测量(目标 2)以及功能性神经想象(目标 3)来表征纤维肌痛和健康对照中强度和情感处理的常见机制,以及表征大脑处理区域在感觉辨别(初级和次级体感皮层)和情感(岛叶和前扣带皮层)处理中的作用。特定的心理物理程序减少了强度和不愉快反应之间的虚假相关性。这些程序和对辨别表现以及相对和绝对厌恶的行为评估将确定两种伤害性刺激(热、压力)和一种非伤害性刺激方式(听觉)中增加的感觉增益和中枢情感增益对纤维肌痛症状的贡献,并进行比较这些是对健康对照受试者的反应。纤维肌痛是一个由未知机制介导的重大健康和经济问题。目前的治疗方法效果有限。一旦了解了引发和维持纤维肌痛的机制,这些知识就可以应用于开发有效的合理治疗方法。我们期望对改变感觉处理的拟议研究将揭示重要信息,从而显着促进对潜在机制的理解。这样的进步意义重大,因为它将指导进一步的治疗研究。我们期望这些结果适用于多种诊断类别,并大大增加对纤维肌痛及相关疾病的理解和治疗。项目叙述:这项研究将增进对纤维肌痛潜在机制的理解。更好地了解机制和疼痛过程将有助于改进治疗方法,并更好地检测谁会对某些类型的治疗产生反应。这项研究的结果还将提供有关表型特征的更好信息,这将有助于指导未来的遗传学研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Richard H Gracely其他文献
Richard H Gracely的其他文献
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{{ truncateString('Richard H Gracely', 18)}}的其他基金
A Necessary Multi-Parametric Evaluation of Vulvodynia
外阴痛必要的多参数评估
- 批准号:
8337013 - 财政年份:2012
- 资助金额:
$ 41.05万 - 项目类别:
A Necessary Multi-Parametric Evaluation of Vulvodynia
外阴痛必要的多参数评估
- 批准号:
8534359 - 财政年份:2012
- 资助金额:
$ 41.05万 - 项目类别:
A Necessary Multi-Parametric Evaluation of Vulvodynia
外阴痛必要的多参数评估
- 批准号:
9097408 - 财政年份:2012
- 资助金额:
$ 41.05万 - 项目类别:
A Necessary Multi-Parametric Evaluation of Vulvodynia
外阴痛必要的多参数评估
- 批准号:
8698643 - 财政年份:2012
- 资助金额:
$ 41.05万 - 项目类别:
PAIN MECHANISMS IN CHRONIC MULTI-SYMPTOM ILLNESSES
慢性多症状疾病的疼痛机制
- 批准号:
7603731 - 财政年份:2007
- 资助金额:
$ 41.05万 - 项目类别:
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