Indoor Air Pollution and Outcomes in Cystic Fibrosis

室内空气污染和囊性纤维化的后果

• 批准号: 10065102
• 负责人: Sara Weller Carson
• 金额: $ 8.74万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-02 至 2021-07-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10065102
• 关键词: Adolescent; Adult; Affect; Air; Asthma; Bacterial Infections; Biometry; Caliber; Cessation of life; Child; Chronic; Chronic Obstructive Airway Disease; Clinic Visits; Clinical; Clinical Research; Communities; Cookstove; Cystic Fibrosis; Data; Data Analyses; Disease; Environment; Environmental Exposure; Environmental Health; Exposure to; Forced expiratory volume function; Foundations; Future; Genetic; Genetic Diseases; Home environment; Hospitalization; Immersion; Individual; Indoor Air Pollution; Indoor environment; Intervention Studies; Life Expectancy; Lung; Lung Transplantation; Lung diseases; Measures; Monitor; Morbidity - disease rate; Nicotine; Nitrogen Dioxide; Obstructive Lung Diseases; Outcome; Ozone; Particulate Matter; Patient Self-Report; Patients; Pilot Projects; Population; Pseudomonas aeruginosa; Public Health; Pulmonary Function Test/Forced Expiratory Volume 1; Questionnaires; Research; Research Design; Respiratory Signs and Symptoms; Respiratory physiology; Seasons; Siblings; Source; Spirometry; Surveys; Time; Tobacco smoke; Training; Twin Multiple Birth; United States; Variant; Wood stove; ambient air pollution; base; catalyst; coarse particles; cohort; cystic fibrosis patients; data management; diaries; environmental tobacco smoke; experience; improved; methicillin resistant Staphylococcus aureus; mortality; non-genetic; premature; prospective; recessive genetic trait; respiratory; survival prediction

PROJECT SUMMARY Cystic Fibrosis (CF) is a lethal autosomal recessive disease affecting nearly 80,000 people worldwide. Despite advances in therapy, CF remains a progressive lung disease that leads to decline in lung function and frequent pulmonary exacerbations. Higher levels of outdoor air pollution, including particulate matter (PM) with a diameter of 10µm or less (PMR10R) and 2.5µm or less (PMR2.5R), nitrogen dioxide (NOR2R), and ozone, have been shown to lead to worse CF outcomes such as decline in lung function and increased pulmonary exacerbations. Many studies have shown that higher levels of indoor air pollution increase morbidity in obstructive lung diseases such as asthma and COPD. To our knowledge, this has not been studied in individuals with CF, also an obstructive lung disease. In this proposal we aim to study how indoor air pollution affects individuals with CF. We hypothesize that higher levels of indoor air pollution are associated with worse CF outcomes, such as increased respiratory symptoms and decline in lung function. To explore our hypothesis, we will conduct a sub-analysis from data collected in the US CF Twin and Sibling Study, which includes data on exposure to sources of indoor air pollution and clinical outcomes on over 2000 CF individuals from 2000-13. Next, we will distribute a survey to our local CF cohort to gather more detailed home exposure data and follow respiratory symptoms and lung function over time. Finally, we will conduct a pilot study to measure daily PMR2.5R and weekly NOR2R and nicotineR Rlevels inside the homes of 20 patients with CF for two one-week periods, separated by season, and ask patients to answer a daily respiratory symptoms questionnaire, complete daily activity diaries, and perform daily home spirometry. We will then determine if daily variations in PMR2.5 Rand weekly levels of NOR2R and nicotine are associated with daily variation in respiratory symptoms and lung function. The research carried out in this proposal is of public health significance and will provide new information on how indoor air pollution affects CF. The results of this study may impact the entire CF community and will serve as a catalyst for a future, multi-center and interventional study which will be the basis for my K23 application.

项目摘要 囊性纤维化（CF）是一种致命的常染色体隐性疾病，影响了全球近80,000人。尽管 治疗的进展，CF仍然是一种进行性肺部疾病，导致肺功能和频率下降 肺部恶化。 较高水平的室外空气污染，包括颗粒物（PM），直径为10µm或更少（PMR10R） 和2.5µm或更少（PMR2.5R），氮二氧化氮（NOR2R）和臭氧已显示出较差的CF 结果，例如肺功能下降和肺部加重增加。许多研究表明 较高水平的室内空气污染增加了阻塞性肺部疾病（例如哮喘和）的发病率 COPD。据我们所知，这尚未在患有CF的个体（也是阻塞性肺部疾病）中进行研究。 在此提案中，我们旨在研究室内空气污染如何影响CF的个人。我们假设这一点 较高水平的室内空气污染与CF结局较差有关，例如呼吸道增加 症状和肺功能下降。 为了探讨我们的假设，我们将对在美国CF Twin和兄弟姐妹收集的数据进行亚分析 研究，其中包括有关2000年以上接触室内空气污染和临床结果的数据的数据 CF个人从2000 - 13年开始。接下来，我们将向当地的CF队列分发一项调查，以收集更多的详细信息 家庭暴露数据并遵循呼吸道症状和肺部功能。最后，我们将进行 测量每日PMR2.5R和每周NOR2R和Notiner Rlevels的试点研究 在两个星期的时间内，按季节分开，并要求患者回答每日呼吸症状 问卷调查，完成日常活动日记，并执行每日肺活量测定法。然后，我们将确定是否 PMR2.5兰德每周NOR2R和尼古丁水平的每日变化与呼吸道的每日变化有关 症状和肺功能。 在此提案中进行的研究具有公共卫生意义，将提供有关的新信息 室内空气污染如何影响参见。这项研究的结果可能会影响整个CF社区，并将 作为未来，多中心和介入研究的催化剂，这将成为我的K23的基础 应用。

项目成果

Indoor air pollution exposure is associated with greater morbidity in cystic fibrosis.

• DOI: 10.1016/j.jcf.2021.08.015
• 发表时间: 2022-03
• 期刊: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
• 作者: Carson SW;Psoter K;Koehler K;Siklosi KR;Montemayor K;Toporek A;West NE;Lechtzin N;Hansel NN;Collaco JM;Merlo CA
• 通讯作者: Merlo CA