Impact of insomnia on substance use in people living with HIV

失眠对艾滋病毒感染者药物使用的影响

• 批准号: 10059153
• 负责人: Burel R. Goodin
• 金额: $ 3.59万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-15 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10059153
• 关键词: Acquired Immunodeficiency Syndrome; Address; Administrative Supplement; Adult; Aging; Agreement; Alabama; Alcohol or Other Drugs use; Alcohols; Anti-Inflammatory Agents; Biological; Biological Markers; Blood; C-reactive protein; Centers for Disease Control and Prevention (U.S.); Circadian Dysregulation; Clinical Research; Clinical Trials; DSM-V; Data; Development; Diagnostic; Discipline of Nursing; Disease; Disease Progression; Faculty; General Population; Genomics; Goals; HIV; Health; Home environment; Individual; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Interdisciplinary Study; Interleukin-6; International; Interview; Knowledge; Laboratories; Learning; Life; Link; Literature; Manuscripts; Maps; Mediator of activation protein; Medicine; Mission; Neurobiology; Pain; Pain Threshold; Parents; Participant; Patient Self-Report; Peer Review; Persons; Pharmaceutical Preparations; Physical Function; Physiological; Pilot Projects; Polysomnography; Population; Prevalence; Procedures; Process; Public Health; Quality of life; Questionnaires; Recording of previous events; Reporting; Research; Research Design; Research Personnel; Research Priority; Research Training; Resources; Risk Factors; Severities; Sleep; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Sleeplessness; Standardization; Stimulus; Structure; TNF gene; Time; Translational Research; United States National Institutes of Health; Universities; Variant; Vulnerable Populations; actigraphy; associated symptom; base; career; career development; chronic pain; college; comorbidity; comparison group; design; diaries; experience; falls; inflammatory marker; innovation; member; monitoring device; pain sensitivity; pain symptom; parent grant; parent project; physically handicapped; recruit; research and development; response; sleep quality; stressor; symposium; tenure track; therapeutic target; training opportunity; trend

Project Summary/Abstract This administrative supplement, in response to PA-18-906: “Research Supplements to Promote Diversity in Health-Related Research (Admin Supp – Clinical Trial Not Allowed)”, will expand the parent project (R01HL147603, PI-Burel R. Goodin), and provide research and career development support for Dr. Shameka L. Cody, a tenure track junior faculty member at The University of Alabama Capstone College of Nursing in Tuscaloosa, AL. Numerous reports of co-occurring symptoms such as poor sleep quality and pain exist among people living with HIV (PLWH) which can negatively impact quality of life. Insomnia, which is characterized by difficulty falling asleep, staying asleep or both, has been reported among 70% of PLWH compared to less than 35% of the general population. Similar to insomnia, over half of PLWH are likely to experience recurring pain symptoms. Pain is a growing concern for PLWH and has been associated with poor sleep quality. Laboratory- based studies have shown that sleep deprivation is associated with increased inflammatory effects, and these same inflammatory effects are associated with increased pain sensitivity. The parent grant for this Diversity Supplement has been designed to examine the impact of insomnia on pain and pain-related inflammatory processes in PLWH. Substance use is another mechanism by which insomnia may promote pain and inflammatory effects in PLWH. Nearly 50% of PLWH report current or past histories of drug or alcohol disorders. Substance use is associated with increased systematic inflammation, and in PLWH, these effects may be more profound and hasten disease progression. Exploring the impact of insomnia on pain and pain-related inflammatory processes in substance users with HIV will enhance the parent study, and represents an innovative training opportunity for a junior faculty. The scientific goals of the supplement are to: (1) augment the parent study with recruitment of PLWH and substance use, (2) examine whether the impact of insomnia on pain and pain-related processes differ by HIV+ substance users, (3) identify the interaction of substance use and insomnia in predicting increased pain sensitivity and elevated inflammatory biomarker levels (i.e., IL-6, TNF-α, and C- reactive protein). This supplement also has three career development goals for Dr. Cody, a promising junior faculty with a background in Nursing, HIV and aging, and sleep quality: (1) acquire expertise in clinical and translational research training in Sleep Medicine; (2) advance her knowledge of poor sleep quality in PLWH and its effects with substance use on quality of life determinants; (3) learn how to build multidisciplinary research teams, present at national and international conferences, develop first-author peer-reviewed manuscripts, and develop a competitive proposal for an early-career investigator R01.

项目概要/摘要 本行政补充，回应 PA-18-906：“促进多样性的研究补充 健康相关研究（管理补充 - 不允许进行临床试验）”，将扩展父项目 （R01HL147603，PI-Burel R. Goodin），并为 Shameka L. 博士提供研究和职业发展支持。 科迪 (Cody) 是阿拉巴马大学凯普斯通护理学院的终身教授 阿拉巴马州塔斯卡卢萨存在许多关于睡眠质量差和疼痛等并发症状的报告。 艾滋病毒感染者 (PLWH) 会对生活质量产生负面影响，其特点是失眠。 据报道，70% 的 PLWH 中存在入睡、保持睡眠或两者兼而有之的困难，而低于 35% 的普通人群与失眠类似，超过一半的感染者可能会经历反复出现的疼痛。 疼痛是感染者日益关注的问题，并且与睡眠质量差有关。 基础研究表明，睡眠不足与炎症反应增加有关，而这些 相同的炎症效应与疼痛敏感性的增加有关。 补充剂旨在检查失眠对疼痛和疼痛相关炎症的影响 艾滋病毒感染者的药物使用过程是失眠可能加剧疼痛和疼痛的另一种机制。 PLWH 中的炎症影响 近 50% 的 PLWH 报告有当前或过去的药物或酒精疾病史。 物质使用与系统性炎症增加有关，对于感染者来说，这些影响可能更严重 探索失眠对疼痛和疼痛相关疾病的影响。 艾滋病毒吸毒者的炎症过程将加强家长研究，并代表了一种创新 初级教师的培训机会 该补充材料的科学目标是： (1) 增强家长的能力。 研究招募了 PLWH 和物质使用，(2) 检查失眠是否对疼痛和药物使用产生影响 HIV+ 物质使用者的疼痛相关过程有所不同，(3) 确定物质使用和失眠之间的相互作用 预测疼痛敏感性增加和炎症生物标志物水平升高（即 IL-6、TNF-α 和 C- 这种补充剂还为科迪博士（一位有前途的大三学生）提供了三个职业发展目标。 具有护理、艾滋病毒和衰老以及睡眠质量背景的教师：(1) 获得临床和睡眠方面的专业知识 睡眠医学转化研究培训；(2) 增进她对艾滋病患者睡眠质量差的认识； (3)学习如何建立多学科研究 出席国内和国际会议的团队，开发第一作者同行评审的手稿，以及 为早期职业研究者 R01 制定竞争性提案。