ALPHA-HERPESVIRUS TRANSPORT IN AXONS

轴突中的α-疱疹病毒运输

• 批准号: 10053129
• 负责人: Gregory Allan Smith
• 金额: $ 40.17万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10053129
• 关键词: Afferent Neurons; Alphaherpesvirinae; Antiviral Agents; Axon; Axonal Transport; Binding Sites; Brain; Capsid; Cell Nucleus; Cells; Centrosome; Complex; DNA Viruses; Disease; Dynein ATPase; Encephalitis; Eye; Family; Family member; Gene Delivery; Genetic; Genome; Goals; Herpes zoster disease; Herpesviridae; Herpesvirus 1; Herpesvirus Type 3; Human Herpesvirus 2; Immunocompetent; Infection; Injections; Invaded; Keratitis; Kinesin; Life; Malignant Neoplasms; Microtubules; Modeling; Morbidity - disease rate; Mothers; Motion; Motor; Mutation; Nervous system structure; Neuroglia; Neurons; Newborn Infant; Nuclear Pore; Oncolytic; Pattern; Peripheral; Production; Property; Proteins; Research; Resources; Role; Simplexvirus; Site; Structure; Synapses; Technology; Tracer; Trauma; Ubiquitination; Vaccines; Varicellovirus; Viral; Viral Genome; Viral Vector; Virion; Virus; Virus Diseases; base; design; expectation; experimental study; human pathogen; latent infection; mad itch virus; member; mortality; neonatal infection; pathogen; programs; recruit; relating to nervous system; repaired; tissue tropism; trafficking; trait; ubiquitin-protein ligase; vector

Spread of neuroinvasive herpesviruses from sensory neurons to the eye, brain or from mother to newborn, are significant causes of morbidity and mortality. Herpes simplex virus type 1 (HSV-1) and pseudorabies virus (PRV) are representative members of the two genuses of mammalian neuroinvasive herpesviruses (Simplexviruses & Varicelloviruses). These viruses are dependent upon spread to the nervous system to establish life-long latent infections, yet very little is known regarding the neuroinvasive mechanism that underlies this remarkable trait. We propose to study the virus neuroinvasive machinery with the intent to: (i) decipher how these viruses invade the nervous system, (ii) understand the intrinsic barriers to neural infection that these viruses evade, and (iii) produce and characterize viruses lacking the neuroinvasive property as potential vaccines. These studies are designed to decode the virus tactics used to establish neural infections and our corresponding nervous system’s defenses that keep most pathogens at bay.

神经毒素的疱疹病毒从感觉神经元到眼睛Y。单纯疱疹病毒1型（HSV-1）和伪虫病毒（PRV）是两个哺乳动物神经毒素的基因的抑制作用，传播到神经系统以使生命感染变成感染，但对于基于特征的神经侵染机制而言，知之甚少。神经感染的固有障碍使用逃避，（iii）产生和表征缺乏神经性侵染特性的病毒作为潜在的疫苗。在海湾。