Device to control circadian-effective light in Alzheimer's disease environments

在阿尔茨海默病环境中控制昼夜节律有效光的装置

• 批准号: 10018621
• 负责人: Erik Page
• 金额: $ 43.29万
• 依托单位: ERIK PAGE AND ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2021-07-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10018621
• 关键词: Affect; Agitation; Algorithms; Alzheimer' s Disease; Alzheimer' s disease related dementia; Back; Behavior; Biological Clocks; Building Codes; Characteristics; Clinical Trials; Cognition; Data; Database Management Systems; Development; Device or Instrument Development; Devices; Dose; Effectiveness; Elderly; Environment; Feeds; Health; Hour; Human; Human Biology; Image; Institutes; Internet; Intervention; Knowledge; Laboratories; Light; Lighting; Machine Learning; Measurement; Measures; Monitor; Moods; Nursing Homes; Optics; Patients; Pattern; Performance; Periodicity; Phase; Phototherapy; Planet Earth; Population; Process; Reporting; Research; Research Personnel; Retina; Rotation; Running; Sleep; Stimulus; System; Technology; Testing; Time; Vision; Visual; Visual system structure; Wakefulness; Wireless Technology; Work; active control; alertness; appropriate dose; awake; base; biological systems; circadian; circadian pacemaker; cloud based; commercialization; design; dosage; effectiveness testing; experience; falls; field study; health data; improved; interest; meter; next generation; novel; prototype; residence; response; success; therapy design

Project Summary This proposed project will develop and field-test a device that accurately monitors and controls the circadian stimulus (CS) for Alzheimer disease (AD) and Alzheimer-disease-related dementia (ADRD) patients in nursing homes. Human biology has evolved to have two distinct optical systems: the visual system, by which we see and process images, and the circadian system, which regulates our biological clock and associated biological systems. These two systems have significantly different spectral and temporal responses to optical input. Specifically, circadian stimulation peaks at 460 nm and responds after several minutes of optical activation, while the visual system peaks at 555 nm and responds nearly instantaneously to inputs. All lighting systems are designed and installed in buildings with consideration only given to the photopic (visual) system and all light meters used to characterize lighting buildings are calibrated to measure photopic light, not CS. While a broad and growing body of research has documented the impacts of the circadian system on human health, including regulating sleep and improving cognition in AD/ADRD patients, research on the CS experienced by AD/ADRD patients is extremely limited. Researchers at the Lighting Research Center at Rensselaer Polytechnic Institute developed the Daysimeter, a calibrated light meter that measures circadian light and circadian stimulus. In Phase I of this project, researchers modified an existing workstation-based lighting control system they previously developed for the visual system to include Daysimeter technology, allowing this control system to record CS measurements. The accuracy of these CS measurements was confirmed in the laboratory and field-testing of 20 of devices is currently ongoing in AD/ADRD nursing homes. In this Phase II application, researchers propose adding control features to this device so that lighting can be controlled to optimize CS dosages in AD/ADRD patient environments. Machine learning-based lighting control algorithms will be driven by continuous light level and spectrum measurements as well as periodic (e.g., daily) patient health data. Data from these devices would be wirelessly transmitted to researchers via an Internet gateway and associated cloud-based data management systems. These data would be of immediate value for gaining a better understanding of AD/ADRD patients' CS exposure and could ultimately result in new lighting systems and/or building codes that consider both our visual and circadian systems. Following the development phase, 30 CS-enabled lighting control systems will be field tested over a 22-week test period. Researchers aim to commercialize this CS-enabled lighting control system shortly after the completion of this field test and the Phase II project specifically targeting AD/ADRD nursing home applications.

项目摘要 该提议的项目将开发并进行测试，以准确监视和控制昼夜节律的设备 阿尔茨海默氏病（AD）和阿尔茨海默氏症相关痴呆（ADRD）患者的刺激（CS） 疗养院。人类生物学已经演变为具有两个不同的光学系统：视觉系统，通过它 我们看到和处理图像以及调节我们的生物钟和相关的昼夜节律系统 生物系统。这两个系统对光学的光谱和时间响应显着不同 输入。具体而言，昼夜节律的刺激在460 nm处峰值，并在光学后几分钟后做出响应 激活，而视觉系统在555 nm处达到峰值，并且几乎瞬间响应输入。所有照明 系统的设计和安装在建筑物中，仅考虑到光波（视觉）系统 并且所有用于表征照明建筑物的光仪都经过校准，以测量光波光，而不是CS。 虽然大量的研究已经记录了昼夜节律对人类的影响 健康，包括调节睡眠和改善AD/ADRD患者的认知，对CS的研究 由AD/ADRD患者体验非常有限。照明研究中心的研究人员 Rensselaer理工学院开发了Daysimeter，这是一种测量昼夜节律的校准灯光计 光和昼夜节律刺激。在该项目的第一阶段，研究人员修改了现有的基于工作站的现有 他们以前为视觉系统开发的照明控制系统包括日常技术， 允许此控制系统记录CS测量。这些CS测量的准确性是 在AD/ADRD护理中正在进行的20个设备的实验室和现场测试中确认 房屋。在此II阶段应用程序中，研究人员建议向该设备添加控制功能，以便照明 可以控制在AD/ADRD患者环境中优化CS剂量。基于机器学习 照明控制算法将由连续的光水平和光谱测量以及 定期（例如，每日）患者健康数据。这些设备的数据将无线传输到 研究人员通过Internet网关和相关的基于云的数据管理系统。这些数据会 可以更好地了解AD/ADRD患者的CS暴露，并且可以直接有价值 最终导致新的照明系统和/或构建代码，这些代码同时考虑我们的视觉和昼夜节律 系统。在开发阶段之后，将在A上测试30个启用CS的照明控制系统 22周的测试期。研究人员的目标是在此后不久将这种支持CS的照明控制系统进行商业化 该现场测试的完成和第二阶段项目专门针对AD/ADRD疗养院 申请。