Mentored patient-oriented research in preschool wheezing disorders

指导以患者为导向的学前喘息障碍研究

• 批准号: 10055039
• 负责人: Anne Mentro Fitzpatrick
• 金额: $ 12.6万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10055039
• 关键词: 6 year old; Address; Adrenal Cortex Hormones; Affect; Age; Anxiety; Area; Asthma; Award; Biological; Caregivers; Child; Chronic Disease; Clinical; Clinical Research; Cohort Studies; Collaborations; Complex; Disease; Economic Burden; Education; Emergency department visit; Ensure; Environment; Esthesia; Expression Profiling; Family; Fatigue; Fostering; Future; Gene Expression; Goals; Health; Impairment; Incidence; Inflammatory; Infrastructure; Intervention Studies; Malignant Neoplasms; Mental Depression; Mental Health; Mentors; Molecular Biology; Morbidity - disease rate; Nursery Schools; Outcome; Pain; Pathway interactions; Patient Outcomes Assessments; Phenotype; Play; Population; Preschool Child; Prevalence; Principal Investigator; Productivity; Psyche structure; Public Health; Quality of life; Recurrence; Research; Research Activity; Research Design; Resources; Respiratory Signs and Symptoms; Role; Severities; Sleep disturbances; Statistical Methods; Statistical Study; Strategic Planning; Symptoms; Testing; Time; Training; United States; Universities; Virus Diseases; Wheezing; Work; affective disturbance; associated symptom; career development; cohort; cost; experience; functional status; hospitalization rates; impaired functional status; improved; innovation; mRNA sequencing; next generation sequencing; novel marker; patient oriented; patient oriented research; personalized intervention; physical conditioning; physical symptom; precision medicine; predict clinical outcome; primary outcome; programs; secondary outcome; social; symptom cluster; symptom science; therapy design; 6 year old; Address; Adrenal Cortex Hormones; Affect; Age; Anxiety; Area; Asthma; Award; Biological; Caregivers; Child; Chronic Disease; Clinical; Clinical Research; Cohort Studies; Collaborations; Complex; Disease; Economic Burden; Education; Emergency department visit; Ensure; Environment; Esthesia; Expression Profiling; Family; Fatigue; Fostering; Future; Gene Expression; Goals; Health; Impairment; Incidence; Inflammatory; Infrastructure; Intervention Studies; Malignant Neoplasms; Mental Depression; Mental Health; Mentors; Molecular Biology; Morbidity - disease rate; Nursery Schools; Outcome; Pain; Pathway interactions; Patient Outcomes Assessments; Phenotype; Play; Population; Preschool Child; Prevalence; Principal Investigator; Productivity; Psyche structure; Public Health; Quality of life; Recurrence; Research; Research Activity; Research Design; Resources; Respiratory Signs and Symptoms; Role; Severities; Sleep disturbances; Statistical Methods; Statistical Study; Strategic Planning; Symptoms; Testing; Time; Training; United States; Universities; Virus Diseases; Wheezing; Work; affective disturbance; associated symptom; career development; cohort; cost; experience; functional status; hospitalization rates; impaired functional status; improved; innovation; mRNA sequencing; next generation sequencing; novel marker; patient oriented; patient oriented research; personalized intervention; physical conditioning; physical symptom; precision medicine; predict clinical outcome; primary outcome; programs; secondary outcome; social; symptom cluster; symptom science; therapy design

PROJECT SUMMARY/ABSTRACT Wheezing is a highly prevalent symptom among preschool children that is notoriously difficult to treat. While the factors associated with wheezing are complex, it is also recognized that preschool children are a heterogeneous group, with differing symptom profiles that may contribute to differing clinical outcomes and disease trajectories. However, symptom science is quite limited in preschool children and has focused primarily on respiratory symptoms in isolation, ignoring other physical symptoms and symptoms of mental and social health in caregivers that are important to overall functional status and quality of life. To date, there has been no attempt to identify or study symptom clusters (defined as two or more concurrent symptoms independent of other clusters) in preschool children with recurrent wheezing. This K24 application entitled “Mentored Patient-Oriented Research in Preschool Wheezing Disorders” seeks five years of support for protected time to expand the Principal Investigator’s mentoring activities, promote her career development and provide momentum to advance her research on symptom clustering in preschool children with recurrent wheezing. The Principal Investigator has built an extensive research program on preschool wheezing in an environment with unparalleled infrastructure, resources and collaborators. Career Development goals are to ensure that the Principal Investigator will be provided sufficient time for mentoring and patient-oriented clinical research activities. The award will also allow the Principal Investigator to further her education in statistical methods and study design, molecular biology, and precision medicine to help her expand her patient-oriented research program. This training will also facilitate the design of interventions to reduce the severity and incidence of wheezing in young children. The overarching research hypothesis is that symptom clusters and their associated inflammatory pathways predict clinical outcomes in preschool children age 12-59 months with recurrent wheezing. Specific aims are to determine whether symptom cluster predicts exacerbation (primary outcome) and quality of life (secondary outcome) and to utilize next-generation sequencing to identify pathways underlying symptom clusters and their trajectories. This project addresses innovative questions in symptom science and may result in identification of novel biomarkers for personalized intervention. Greater understanding of symptoms underlying morbidity will also help tackle a critical public health problem (wheezing) that affects a growing proportion of children in the United States.

项目摘要/摘要 喘息是学龄前儿童中极为普遍的症状，众所周知，很难治疗。尽管 与旋转相关的因素很复杂，还认识到学龄前儿童是一个 异构群体，具有区分症状特征，可能有助于区分临床结果和 疾病轨迹。但是，症状科学在学龄前儿童中非常有限，并且专注于 孤立的呼吸症状的主要症状，忽略了其他身体症状和精神症状 护理人员的社会健康对整体功能状况和生活质量很重要。迄今为止，有 我们没有尝试识别或研究符号簇（定义为两个或多个并发症状 独立于其他群集）中的幼儿园儿童。此K24申请标题为 “学龄前疾病的指导性患者研究”寻求五年的支持 保护时间扩大主要研究者的心理活动，促进她的职业发展和 提供势头，以提高她对复发学龄前儿童的同类聚类的研究 摇动。首席调查员已经建立了一项广泛的研究计划，涉及学龄前儿童 具有无与伦比的基础架构，资源和合作者的环境。职业发展目标是 确保将为主要研究者提供足够的时间进行心理和以患者为导向的临床 研究活动。该奖项还将允许主要研究人员进一步学习统计的教育 方法和研究设计，分子生物学和精确医学，以帮助她扩大以患者为导向的 研究计划。该培训还将促进干预措施的设计，以减少严重性和 幼儿惠灵的发生率。总体研究假设是症状簇和 他们相关的炎症途径可预测12-59个月的学龄前儿童的临床结果 循环旋转。具体目的是确定症状聚类预测是否加剧（主要 结果）和生活质量（次要结果），并利用下一代测序来识别 症状簇及其轨迹的途径。该项目解决了创新的问题 症状科学，可能会导致对个性化干预的新型生物标志物的识别。更大 了解发病率的症状也将有助于解决关键的公共健康问题 （喘息）会影响美国越来越多的儿童。