Highspeed, motion-stabilized, handheld OCTA for pediatric imaging

用于儿科成像的高速、运动稳定、手持式 OCTA

• 批准号: 10042752
• 负责人: JOSEPH A IZATT
• 金额: $ 19.58万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10042752
• 关键词: Address; Adult; Age related macular degeneration; Angiography; Applications Grants; Archives; Birth; Blindness; Blood Vessels; Brain Injuries; Brain imaging; Characteristics; Child; Childhood; Clinical; Computer software; Data; Detection; Development; Diabetic Retinopathy; Diagnosis; Disease; Engineering; Environment; Etiology; Excision; Eye; Feedback; Financial compensation; Funding; Glare; Gold; Hand; Image; Infant; Infant Care; Infant Development; Infant Incubators; Lasers; Lead; Life; Longitudinal Studies; Measurement; Modality; Monitor; Morphologic artifacts; Motion; Nature; Neonatal Intensive Care Units; Newborn Infant; Ophthalmologist; Ophthalmology; Ophthalmoscopes; Optical Coherence Tomography; Optics; Outcome; Pathology; Pediatrics; Photography; Population; Premature Infant; Protocols documentation; Publications; Publishing; Pupil; Research Project Grants; Retina; Retinal Diseases; Retinopathy of Prematurity; Risk; Sampling; Scanning; School-Age Population; Source; Speed; System; Technology; Time; Tissue imaging; Translations; United States National Institutes of Health; Visual impairment; awake; base; clinical application; design; diagnosis standard; diencephalon; experience; gaze; imager; imaging modality; imaging system; in vivo; infancy; insight; non-invasive imaging; novel; prototype; rapid growth; retinal imaging; signal processing; success; time use

In pre-term infants the development of the retina and retinal vasculature is incomplete at birth and progresses rapidly during the infant’s first few months of life. Many pediatric retinal diseases, including retinopathy of prematurity (ROP), have a vascular etiology and are caused by mal-development of retinal vasculature during this period of rapid growth. Preterm infants at risk for ROP make up 1.4% of the newborn population. Optical coherence tomography (OCT) is a non-invasive imaging modality that can provide micron scale imaging of tissue in vivo. This characteristic has made OCT the gold standard for diagnosis and monitoring of diseases in adult ophthalmology. More recently the development of OCT angiography (OCTA) has led to new insights into diseases such as diabetic retinopathy. However, the OCTA systems used in these studies are large tabletop systems that cannot be readily used to image infants in the neonatal intensive care unit (NICU). In order to bring OCT into the NICU, over the last decade our Duke team has become world leaders in the development and use of handheld optical coherence tomography (HH-OCT) systems. We pioneered the use of HH-OCT in the NICU. Our experience with the use and design of HH-OCT systems have pointed out a glaring need in pediatric ophthalmology. While OCT technology in commercial tabletop systems has progressed rapidly to include new highspeed OCT technologies capable of OCTA, commercial HH-OCT systems still use slower, decade old OCT 32 kHz spectral domain OCT engines. Under previous NIH funding (RO1 EY025009) we have leveraged our expertise in the development of handheld ophthalmic imaging systems to develop a prototype handheld OCT angiography (HH-OCTA) probe based on a 200 kHz OCT engine that has provided initial OCTA images of retinal vascular development and pathology in awake, pre-term infants in the NICU. This Research Project Grant proposal aims to bring together a team of optical engineers and pediatric ophthalmologists with expertise in the design and translation of HH-OCT systems for the purpose of developing significant improvements to the HH-OCTA hardware descried by the following specific aims: Specific aim 1: Development of a high speed, handheld OCTA system with 6-axis motion stabilization: For this proposal we will develop a motion stabilized HH-OCTA system that uses and 800 kHz engine and feedback from an inertial measurement unit to provide 6 axis active compensation of operator hand motion. Specific aim 2: Development of single modality (OCT) retinal tracking and eye motion correction: We will develop new scanning protocols and software that will enable real time detection, removal, and re-scanning of motion artifacts in without the need for scanning laser ophthalmoscope or other similar imaging modality. The expected outcome of this proposal is the design of a highspeed, motion stabilized HH-OCTA system capable of wide field, motion corrected imaging. Given the vascular nature of many pediatric retinal diseases we expect that these images will lead to new insights into the development of the retina in both diseased and normal states.

在前婴儿中 在婴儿生命的头几个月中迅速。许多小儿视网膜疾病，包括 早产（ROP），具有血管病因，是由残留脉管系统的不良发育引起的 这一快速增长时期。有ROP风险的早产儿占新生儿人口的1.4％。光学的 相干断层扫描（OCT）是一种非侵入性成像方式，可以提供组织的微米尺度成像 体内。该特征使OCT成为成人诊断和监测疾病的金标准 眼科。最近，OCT血管造影的发展（OCTA）导致了新的见解 糖尿病性视网膜病等疾病。但是，这些研究中使用的八颗系统是大型桌面 无法轻易用于在新生儿重症监护病房（NICU）中对婴儿进行图像的系统。 为了将OCT带入NICU，在过去的十年中，我们的公爵团队已成为世界领导人 手持式光学相干断层扫描（HH-OCT）系统的开发和使用。我们开创了使用 NICU中的HH-OCT。我们在HH-OCT系统的使用和设计方面的经验指出了一个明显的 小儿眼科的需求。虽然商业桌面系统中的OCT技术迅速发展 为了包括能够使用八八的新的高速八十多个技术，商业HH-OCT系统仍然使用较慢， 十年OLD 32 KHz光谱域Oct发动机。根据先前的NIH资金（RO1 EY025009），我们有 利用我们在制定手持式眼科成像系统开发的专业知识来开发原型 手持式OCT血管造影（HH-OCTA）探测基于200 kHz OCT发动机，该发动机提供了初始的八 清醒中的视网膜血管发育和病理的图像，NICU的前婴儿。这项研究 项目赠款提案旨在将光学工程师和小儿眼科医生组成的团队与 HH-OCT系统的设计和翻译专业知识，目的是发展重要 改进以下特定目的描述的HH-OCTA硬件：特定目标1：开发 具有6轴运动稳定的高速，手持式八颗系统：对于此提案，我们将发展 运动稳定的HH-OCTA系统，该系统使用和800 kHz发动机和惯性测量的反馈 单位提供6轴主动补偿的操作员手动赔偿。特定目的2：开发单身 模态（OCT）视网膜跟踪和眼动校正：我们将制定新的扫描协议和 可以实时检测，删除和重新扫描运动工件的软件，而无需 扫描激光眼镜镜或其他类似的成像方式。该提议的预期结果是 高速运动稳定的HH-OCTA系统的设计，能够具有广泛的场，运动校正成像。 鉴于许多小儿视网膜疾病的血管性质，我们希望这些图像会带来新的见解 在患病和正常状态下的视网膜发展。