RP 1: Modeling Forelimb Motor Circuit Organization and Function

RP 1：前肢运动电路组织和功能建模

基本信息

批准号：
10011918
负责人：
Tatyana O. SHARPEE
金额：
$ 28.14万
依托单位：
SALK INSTITUTE FOR BIOLOGICAL STUDIES
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-15 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10011918
关键词：
Address Affect Architecture Behavior Behavioral Brain Cervical Cervical spinal cord structure Computational Technique Computer Analysis Coupled Data Elbow Electrophysiology (science)Elements Extensor Fire - disasters Flexor Forelimb Freedom Future Goals Hodgkin-Huxley model Interneurons Investigation Isometric Exercise Isotonic Exercise Joints Kinetics Limb structure Measurement Measures Mechanics Modeling Molecular Motor Motor Activity Motor Neurons Motor output Movement Mus Muscle Neuromechanics Neurons Output Pattern Periodicity Positioning Attribute Property Psychological Techniques Public Domains Research Project Grants Signal Transduction Slice Source Code Spinal Spinal Cord Testing Time Work Wrist base cell type central pattern generator data sharing networks excitatory neuron experimental analysis experimental study in vivo inhibitory neuron joint mobilization kinematics limb movement motor behavior network models neural circuit neuronal circuitry recruit repository response simulation

项目摘要

Project Summary: Project 1 – Modeling Forelimb Motor Circuit Organization and Function This Research Project addresses the dynamics of motor circuits in the cervical spinal cord. Aims in this project will analyze how cervical spinal networks coordinate forelimb movement during rhythmic and non-rhythmic activity. The model will include neuronal elements (excitatory and inhibitory pre-motor neurons and antagonist pools of motor neurons), antagonist pairs of muscles, and mechanical components of the limb. Theoretical and computational techniques will be used to describe how these elements interact, including possible responses to descending brain commands, to generate forelimb activities such as isometric and isotonic movements. The first goal will be to compute how cervical spinal motor neurons fire in response to inputs (based on slice electrophysiology experiments, Projects 2 and 3), and how their firing is converted to muscle force (based on EMG recordings, Project 4). A second goal will be to analyze circuit configurations that achieve maximum control in order and predict new functional cell types that may be present in the spinal cord. Network models composed of motor and pre-motor neurons will then be constructed, defining the patterns of network firing and bursting of antagonistic motor pools, corresponding to elbow and wrist movements and static states. The model will be constrained by connectivity data (Project 2), and informed by theoretical analyses of optimal circuit configurations. Finally, a mechanical model of the limb will be connected to the neuronal model to generate a coherent picture of the transformation from descending input to the cervical spinal cord to limb movements. The dynamical responses of the model will be compared with the behavioral and in vivo electrophysiological data collected in Project 4. Overall, the theoretical analyses performed here, together with experimental investigations from Projects 2-4, will help inform general principles concerning how multiple neuronal types coordinate their response properties to achieve robust control of multiple dynamical variables.

项目摘要：项目1 - 建模前肢电机电路组织和功能该研究项目涉及颈脊髓中运动电路的动力学。目标在这个项目中将分析宫颈脊柱网络如何在节奏和非节律期间的前肢运动活动。该模型将包括神经元元素（兴奋性和抑制性运动前神经元和拮抗剂运动神经元的池），肌肉的拮抗剂对和肢体的机械成分。理论和计算技术将用于描述这些元素如何相互作用，包括对下降大脑命令，生成前肢活动，例如等距和等渗运动。第一个目标是计算颈椎运动神经元如何响应输入（基于切片）电生理实验，项目2和3），以及如何将其发射转换为肌肉力（基于 EMG录音，项目4）。第二个目标是分析实现最大控制的电路配置按顺序和预测脊髓中可能存在的新功能细胞类型。网络模型组成然后将构建电动机和运动前神经元的电动神经元，定义网络射击和爆发的模式拮抗运动池，对应于肘部和腕部运动以及静态状态。该模型将是受到连接数据（项目2）的约束，并通过最佳电路配置的理论分析告知。最后，肢体的机械模型将连接到神经元模型，以生成连贯的图像从降落输入到颈脊髓到肢体运动的转变。动力学该模型的响应将与收集的行为和体内电生理数据进行比较项目4。总体而言，这里进行的理论分析以及来自项目2-4，将有助于告知有关多种神经元类型如何协调其响应的一般原则属性以实现对多个动态变量的强大控制。