Core 2: Biostatistics and Bioinformatics

核心2：生物统计学和生物信息学

• 批准号: 10037511
• 负责人: Terry HYSLOP
• 金额: $ 12.87万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-14 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10037511
• 关键词: Address; Adherence; Adopted; Area; Awareness; Bioinformatics; Bioinformatics Shared Resource; Biological; Biological Markers; Biometry; Catchment Area; Clinical; Cloud Computing; Code; Communities; Complex; Computer software; Computing Methodologies; Consult; Custom; Data; Data Collection; Data Provenance; Data Science; Databases; Deposition; Development; Doctor of Philosophy; Documentation; Education; Ensure; Environment; Environmental Exposure; Environmental Health; Event; Experimental Designs; Food; Foundations; Funding; Future; Genomics; Goals; Health; Health system; Human Resources; Infrastructure; Institutes; Joints; Leadership; Licensing; Life Style; Machine Learning; Malignant Neoplasms; Manuscripts; Methodology; Methods; Minority; Mission; Modeling; Pathology; Performance; Phenotype; Policies; Population; Practice Management; Preparation; Procedures; Quality Control; RNA Splicing; Reporting; Reproducibility; Reproducibility of Results; Research; Research Design; Research Personnel; Research Support; Resources; Security; Services; Source Code; Statistical Data Interpretation; Statistical Methods; Technical Expertise; Therapeutic Intervention; Translational Research; United States National Institutes of Health; Validation; Work; analysis pipeline; anticancer research; cancer health disparity; career; computerized tools; cost effective; data integrity; data management; data quality; data sharing; design; improved; literate; novel; posters; programs; psychosocial; recruit; scientific computing; social; sound; tool; transcriptome sequencing

ABSTRACT – Biostatistics and Bioinformatics Core (Core 2) The mission of the Biostatistics and Bioinformatics Core is to provide biostatistics and bioinformatics expertise in support of cancer health disparities research in the Duke Cancer Health Disparities (DCHD) P20 SPORE program. The Core will serve as a centralized resource for expertise in applied and theoretical cancer biostatistics and bioinformatics, data science, machine learning, and scientific computing. The Core will be co-led by Terry Hyslop, PhD, and Kouros Owzar, PhD, who have a combined 35 years of cancer biostatistics and bioinformatics technical expertise and leadership, along with their joint research expertise in development of statistical methodologies for analysis of admixed populations. The Core mission will be accomplished within the framework of sound data provenance and statistical principles, literate programming, and reproducible analysis. The code to reproduce analyses will be tracked using source code management software and disseminated publicly. Any software extended or developed de novo by this Core in support of the proposed research will be disseminated to the cancer research community with adequate documentation and under a free public license. Core 2 will provide basic, clinical, and translational cancer biostatistics and bioinformatics support (Aim 1); evaluate statistical and computational methods and tools (Aim 2); and provide consulting and education to support current and future DCHD P20 projects (Aim 3). The Core will provide cancer biostatistics and bioinformatics expertise in support of the research proposed by Project 1 and Project 2. This will ensure that the projects have clearly stated quantitative objectives, comprehensive data quality control plans, and clearly defined interim and final analysis plans using appropriate statistical and computational methodology, and computing infrastructure. Core personnel will produce interim and final reports, programmatic data checks and validation, and contribute to abstract, poster, and manuscript preparation. For Project 1, the Core will provide RNA sequencing analysis support from initial quality control assessment of raw reads and pre-processing, to downstream statistical analysis and annotation. Core personnel will actively collaborate with the proposed Biospecimen/Pathology Core in the sequencing design. For Project 2, the Core has provided the statistical design and analysis plan for the proposed studies and will provide statistical and data management support from the recruitment to the final analysis stage. Core leaders will actively consult with and educate program investigators, as well as Developmental Research Program (DRP) and pre Career Enhancement Program (pre-CEP) awardees. This will help investigators to more deeply understand their projects’ quantitative results, including both the limitations in making inferences from a particular experimental design, and also in proper interpretation of their findings. The Biostatistics and Bioinformatics Core serves all Projects, consults and works with DRP & pre-CEP awardees, is represented on the Executive Committee, and works closely with the Biospecimen/Pathology Core and the Administrative Core. Our services are crucial to achieving the shared goals of the DCHD P20 SPORE.

摘要 - 生物统计学和生物信息学核心（核心2） 生物统计学和生物信息学核心的使命是提供生物统计学和生物信息学专业知识 支持癌症癌症健康差异（DCHD）P20孢子的癌症健康差异研究 程序。该核心将作为用于应用和理论癌症生物统计学专业知识的集中资源 以及生物信息学，数据科学，机器学习和科学计算。核心将由特里共同领导 Hyslop，PhD和Kouros Owzar，PhD，共有35年的癌症生物统计学和生物信息学 技术专长和领导力，以及他们在统计开发方面的共同研究专业知识 分析混合种群的方法。核心任务将在框架内完成 声音数据出处和统计原理，识字编程和可再现分析。代码 复制分析将使用源代码管理软件跟踪并公开传播。任何 该核心将扩展或开发的软件以支持拟议的研究而从头开发或开发 通过足够的文档并获得免费的公共许可证，向癌症研究界致敬。 Core 2 Will 提供基本，临床和翻译的癌症生物统计学和生物信息学支持（AIM 1）；评价 统计和计算方法和工具（AIM 2）；并提供咨询和教育以支持当前 以及未来的DCHD P20项目（AIM 3）。核心将提供癌症生物统计学和生物信息学专业知识 为了支持项目1和项目2提出的研究。这将确保这些项目显然具有 陈述了定量目标，全面的数据质量控制计划以及明确定义的临时和最终 分析计划使用适当的统计和计算方法以及计算基础架构。核 人员将产生临时和最终报告，程序化数据检查和验证，并有助于 摘要，海报和手稿准备。对于项目1，核心将提供RNA测序分析 初始质量控制评估的原始阅读和预处理的支持，以及下游统计数据 分析和注释。核心人员将积极与拟议的生物晶体/病理合作 测序设计中的核心。对于项目2，核心提供了统计设计和分析计划 拟议的研究将提供招聘到最终的统计和数据管理支持 分析阶段。核心领导者将积极咨询和教育计划调查员以及 发展研究计划（DRP）和职业前增强计划（CEP PRE-CEP）获奖者。这 将帮助调查人员更深入地了解其项目的定量结果，包括这两个局限性 从特定的实验设计以及对其发现的正确解释时。 生物统计学和生物信息学核心核心为DRP和CEP PRE-CEP获奖者的所有项目，关注和合作服务， 在执行委员会中代表，并与生物测试/病理核心密切合作 行政核心。我们的服务对于实现DCHD P20孢子的共同目标至关重要。