ACQUISITION OF HUMAN HERPES VIRUS-8 IN INFANCY

在婴儿期获得人类疱疹病毒 8

• 批准号: 7604837
• 负责人: Charles F. Grose
• 金额: $ 0.16万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604837
• 关键词: Birth; Blood; Cells; Child; Computer Retrieval of Information on Scientific Projects Database; Condition; Contracts; Disease; Epithelial Cells; Funding; Goals; Grant; Herpesviridae; Human; Human Herpes Virus 8 Infection; Human Herpesvirus 4; Human Milk; Immunosuppressive Agents; Infant; Infection; Institution; Kaposi Sarcoma; Life; Link; Newborn Infant; Oral; Oral cavity; Persons; Research; Research Personnel; Resources; Route; Simplexvirus; Source; United States; United States National Institutes of Health; early childhood; infancy; neonate; pathogen; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human herpes virus 8 (HHV-8), also called Kaposi's sarcoma herpesvirus (KSHV), was first described in 1994. This herpes virus is most similar to Epstein-Barr virus, another human herpes pathogen. Several other diseases have subsequently been linked to HHV-8. A key issue is how and when people acquire HHV-8 infection. Many human herpesviruses are acquired in early childhood and thereafter have decades long latency period before emerging in mid to late adulthood. The goal of this proposal is to investigate HHV-8 infection in infancy and its route of transmission in neonates born in the United States. The overall goal of this project is to determine the percent of infants who contract HHV-8 infection during the first year of life. These investigators postulate that HHV-8 infection is contracted in the first year of life in more children than previously suspected. In particular, they propose that the infection may be acquired perinatally or in the first few months of life. Presumably maternal blood, secretions in the birth canal, or breast milk would transfer infectivity to the newborn. Oral epithelial cells in the infants mouth are a susceptible cell. Thereafter, the infection would be asymptomatic until late adulthood, unless the person acquired an immunosuppressive condition.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 人类疱疹病毒 8 型 (HHV-8)，也称为卡波西肉瘤疱疹病毒 (KSHV)，于 1994 年首次被描述。这种疱疹病毒与另一种人类疱疹病原体 Epstein-Barr 病毒最相似。 随后其他几种疾病也与 HHV-8 有关。 一个关键问题是人们如何以及何时感染 HHV-8。 许多人类疱疹病毒是在儿童早期获得的，此后有数十年的潜伏期，然后在成年中后期出现。 该提案的目标是调查婴儿期 HHV-8 感染及其在美国出生的新生儿中的传播途径。 该项目的总体目标是确定婴儿在出生第一年感染 HHV-8 的百分比。 这些研究人员推测，在生命第一年感染 HHV-8 的儿童数量比之前怀疑的要多。 特别是，他们提出感染可能是在围产期或出生后的最初几个月内获得的。 据推测，母体血液、产道分泌物或母乳会将传染性传染给新生儿。 婴儿口腔中的口腔上皮细胞是易感细胞。 此后，除非该人出现免疫抑制症状，否则感染直到成年晚期才会出现症状。