mDOT TR&D3 (Translation): Translation of Temporally Precise mHealth via Efficient and Embeddable Privacy-aware Biomarker Implementations

mDOT TR

基本信息

批准号：
10025134
负责人：
Emre Ertin
金额：
$ 30.18万
依托单位：
UNIVERSITY OF MEMPHIS
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至 2025-11-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10025134
关键词：
Address Algorithmic Software Algorithms Architecture Awareness Behavioral Biological Markers Cellular Phone Chronic Disease Clinic Cloud Computing Collaborations Collection Communication Communities Companions Computational Technique Computer software Computing Methodologies Data Data Collection Development Devices Disease Outcome Eating Ensure Fatigue Feedback Frequencies Generations Health Healthcare Image Individual Infrastructure Intelligence Intervention Lead Life Machine Learning Medical Medicine Metadata Methodology Methods Modality Motion Noise Observational Study Ohio Participant Patients Personally Identifiable Information Physiological Physiology Principal Investigator Privacy Research Research Activity Research Design Research Personnel Resources Risk Running Sampling Services Side Signal Transduction Smoking Software Design Stream Stress Structure System Technology Time Training Translations Trust Universities Work base biopsychosocial cloud platform craving data anonymization data sharing denoising design digital health management healthy lifestyle high dimensionality improved mHealth machine learning algorithm mobile computing multiple chronic conditions next generation open source point of care prevent prototype public health relevance radio frequency reconstruction research study sensor signal processing software development synergism technological innovation technology research and development tool usability wearable sensor technology

项目摘要

Principal Investigator: Kumar, Santosh TR&D3: Translation of Temporally Precise mHealth via Efficient and Embeddable Privacy-aware Biomarker Implementations Lead: Dr. Emre Ertin, The Ohio State University; 10% effort (1.2 CM) Abstract: The mHealth Center for Discovery, Optimization & Translation of Temporally-Precise Interventions (the mDOT Center) will enable a new paradigm of temporally-precise medicine to maintain health and manage the growing burden of chronic diseases. The mDOT Center will develop and disseminate the methods, tools, and infrastructure necessary for researchers to pursue the discovery, optimization and translation of temporally- precise mHealth interventions. Such interventions, when dynamically personalized to the moment-to-moment biopsychosocial-environmental context of each individual, will precipitate a much-needed transformation in healthcare by enabling patients to initiate and sustain the healthy lifestyle choices necessary for directly managing, treating, and in some cases even preventing the development of medical conditions. Organized around three Technology Research & Development (TR&D) projects, mDOT represents a unique national resource that will develop multiple methodological and technological innovations and support their translation into research and practice by the mHealth community in the form of easily deployable wearables, apps for wearables and smartphones, and a companion mHealth cloud system, all open-source. TR&D3 will develop, validate and disseminate algorithms, tools and software/hardware designs for translation of temporally-precise mHealth interventions through resource efficient, real time, low-latency and privacy-aware implementation of an array of digital biomarkers that can be deployed at scale. Our approach is centered around a hierarchical computing framework that reduces the data into minimal modular abstractions called Micromarkers computed at the edge devices (Aim 1). Modular Micromarker abstractions are used to compress task-specific information relevant to biomarker computations at the edge devices while stripping nuisance variables such as hardware biases/drifts and background levels not pertinent to inference. Our hierarchical computing framework can be extended to implement high data rate sensor arrays at edge devices to be used at new point of care and ambulatory settings. This is accomplished through integrating a compressive sensing pre-processor to achieve signal acquisition in a resource constrained setting (Aim 2). Finally, TR&D3 will create computational mechanisms and a general biomarker privacy framework to enable participant control over the privacy-utility trade-offs during study design, data collection, and sharing of collected mHealth data for third party research when data cross trust domains (Aim 3). These technologies will be developed in collaboration with collaborative projects and will be disseminated to service projects to ensure that TR&D3 technologies can solve real problems facing the health research community and ensure the usability of these technologies by investigators who are external to the mDOT investigating team. TR&D3 will synergistically work in partnership with the other TR&D projects, the Training and Dissemination Core, and the Administration Core to maximize the societal impact of TR&D3 technologies. 1

首席研究员：库马尔，桑托什 TR&D3：通过高效且可嵌入的隐私意识实现时间精确的移动医疗生物标记实施负责人：Emre Ertin 博士，俄亥俄州立大学； 10% 努力 (1.2 CM) 摘要：移动医疗中心用于发现、优化和转化时间精确干预措施（mDOT 中心）将实现时间精确医学的新范式，以维持健康和管理慢性病负担日益加重。 mDOT 中心将开发和传播方法、工具、以及研究人员追求时间发现、优化和翻译所必需的基础设施精准的移动医疗干预。当这种干预措施根据时时刻刻进行动态个性化时每个人的生物心理社会环境背景，将促成急需的转变通过使患者能够启动并维持直接健康所需的健康生活方式选择来实现医疗保健管理、治疗，在某些情况下甚至预防疾病的发展。有组织 mDOT 围绕三个技术研发 (TR&D) 项目代表了独特的国家将开发多种方法和技术创新并支持其翻译的资源移动医疗社区以易于部署的可穿戴设备、应用程序的形式参与研究和实践可穿戴设备和智能手机，以及配套的 mHealth 云系统，全部都是开源的。 TR&D3 将开发、验证和传播用于翻译的算法、工具和软件/硬件设计通过资源高效、实时、低延迟和隐私意识实现时间精确的移动医疗干预实施一系列可大规模部署的数字生物标记。我们的方法围绕一种分层计算框架，可将数据简化为称为微标记的最小模块化抽象在边缘设备上计算（目标 1）。模块化微标记抽象用于压缩特定于任务的与边缘设备上的生物标记计算相关的信息，同时去除诸如硬件偏差/漂移和背景水平与推理无关。我们的分层计算框架可以扩展以在边缘设备上实现高数据速率传感器阵列，以用于新的护理点和流动设置。这是通过集成压缩传感预处理器来实现的资源受限环境中的信号采集（目标 2）。最后，TR&D3 将创建计算机制和通用生物标记隐私框架，使参与者能够控制隐私实用程序研究设计、数据收集以及为第三方研究共享收集的移动医疗数据期间的权衡当数据跨信任域时（目标 3）。这些技术将与合作项目合作开发，并将传播给确保TR&D3技术能够解决健康研究面临的实际问题的服务项目社区并确保 mDOT 外部的调查人员可以使用这些技术调查组。 TR&D3 将与其他 TR&D 项目、培训和传播核心和管理核心，以最大限度地发挥 TR&D3 技术的社会影响。 1