Neurocognitive Targets of Hostile Interpretation Bias Training to Treat Irritability

治疗烦躁的敌意解释偏差训练的神经认知目标

基本信息

批准号：
10004740
负责人：
Joel Johnson Stoddard
金额：
$ 18.97万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2023-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10004740
关键词：
Adolescent Advanced Development Adverse effects Affective Amygdaloid structure Anterior Area Behavior assessment Behavioral Benchmarking Benign Child Childhood Chronic Clinic Clinical Cognitive Collaborations Colorado Computer Models Computing Methodologies Development Dimensions Disease Doctor of Medicine E-learning Educational Activities Emotions Evaluation Evidence based treatment Face Fellowship Foundations Functional Magnetic Resonance Imaging Goals Impairment Intervention Judgment Learning Measures Mediating Medical Mental Health Mental disorders Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Methods Modeling Mood Disorders National Institute of Mental Health Nature Neurocognitive Outcome Outpatients Participant Pathologic Patient Education Patients Population Psychopathology Randomized Randomized Controlled Trials Research Research Domain Criteria Research Personnel Research Project Grants Resources Series Single-Blind Study Stimulus Sum System Techniques Training Training Programs Translating Translations Universities Vision Work Writing Youth brain behavior cingulate cortex clinically significant cognitive retraining design efficacy testing efficacy trial evidence base improved interest medical schools neuroimaging novel placebo group professor programs psychiatric symptom relating to nervous system response responsible research conduct side effect skills social therapeutic target therapy development treatment effect

项目摘要

PROJECT SUMMARY/ABSTRACT My long term goal is to independently investigate evidence-based therapeutics targeting the neurocognitive basis of affective disorders in youth. As a critical first step, the objectives of the research plan are to advance the development of interpretation bias training (IBT) to treat severe, chronic irritability in youth. Few evidence-based treatments exist for irritability, despite its impairing nature and long-lasting adverse effects. By establishing the targets of interpretation bias training, this treatment may be advanced towards efficacy trials. Whatever the outcome, this project will inform us of the neurocognitive basis of pathologic irritability, ultimately improving the mental health of irritable youth. My clinical interests led to an NIMH Clinical Fellowship to learn behavioral assessment and functional magnetic resonance imaging (fMRI) of youth with severe affective psychopathology. The Fellowship prepares trainees to seek independence via a K-series mechanism. Now, as an Assistant Professor at the University of Colorado (CU) School of Medicine, I have support to train to independence through a K23 mechanism. CU has resources at its medical and Boulder campuses necessary to pursue training in computational modeling, its application to neuroimaging, to further our understanding of pediatric mental illness. My mentorship team is led by Guido Frank, M.D. and includes experts in computational modeling and neuroimaging (Drs. Frank and Jones) as well as affective psychopathology and cognitive retraining trials (Drs. Leibenluft and Pine). My training plan provides the foundation for an independent research program. My training objectives are to: (1) train in the application and evaluation of cognitive retraining techniques to pediatric mental illness, (2) train in the development of computationally-intensive models describing brain-behavior interactions, (3) train in advanced neuroimaging and programming, (4) improve my research collaboration, writing, and presentation skills, (5) obtain additional training in the responsible conduct of research. I will accomplish these training objectives through coursework and other educational activities, guidance from my mentors/consultants, and completion of my research project. The research project proposed in this application is the first study to examine the neural and cognitive underpinnings of a recently developed IBT program to treat irritability transdiagnostically. It lays the foundation for a preliminary test of efficacy of IBT on irritability by establishing IBT's neurocognitive treatment targets: hostile interpretation bias and response in the neural threat-learning system. The design is a single-blinded, randomized controlled trial of IBT on its targets. We plan to apply established computational models to measure target response to IBT.

项目概要/摘要我的长期目标是独立研究针对以下疾病的循证疗法青少年情感障碍的神经认知基础。作为关键的第一步，研究计划的目标旨在推动解释偏见训练（IBT）的发展，以治疗青少年严重的慢性烦躁情绪。尽管烦躁性有损害性且具有长期的不利影响，但针对烦躁性的循证治疗方法却很少。影响。通过建立解释偏差训练的目标，这种治疗可能会朝着以下目标推进：功效试验。无论结果如何，这个项目都将告诉我们病理学的神经认知基础烦躁，最终改善烦躁青少年的心理健康。我的临床兴趣让我获得了 NIMH 临床奖学金，学习行为评估和功能评估对患有严重情感精神病理学的青少年进行磁共振成像（fMRI）。联谊会准备学员通过K系列机制寻求独立。现在，作为大学助理教授科罗拉多 (CU) 医学院，我通过 K23 机制获得独立训练的支持。 CU有其医学和博尔德校区的资源是进行计算建模培训所必需的，其应用于神经影像学，以加深我们对儿科精神疾病的了解。我的导师团队由由医学博士吉多·弗兰克 (Guido Frank) 撰写，包括计算建模和神经影像学专家（弗兰克博士和 Jones）以及情感精神病理学和认知再训练试验（Leibenluft 博士和 Pine 博士）。我的培训计划为独立研究计划奠定了基础。我的培训目标是：（1）培训认知再培训技术在儿科精神疾病中的应用和评估，(2) 培训开发描述大脑行为相互作用的计算密集型模型，(3) 训练高级神经影像和编程，(4) 改善我的研究协作、写作和演示技能，(5) 获得负责任的研究行为的额外培训。我将完成这些训练通过课程作业和其他教育活动、导师/顾问的指导实现目标，以及完成我的研究项目。本申请中提出的研究项目是第一个检查神经和认知的研究最近开发的 IBT 计划的基础，用于跨诊断治疗烦躁。它奠定了基础通过建立 IBT 的神经认知治疗目标来初步测试 IBT 对烦躁的功效：神经威胁学习系统中的敌对解释偏差和反应。该设计是单盲的， IBT 对其目标的随机对照试验。我们计划应用已建立的计算模型测量 IBT 的目标反应。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Editorial: Defining the Clinical Boundary of Disruptive Mood Dysregulation Disorder Symptoms in Youth.

社论：定义青少年破坏性情绪失调障碍症状的临床界限。

DOI：
10.1016/j.jaac.2020.12.019
发表时间：
2021
期刊：
Journal of the American Academy of Child and Adolescent Psychiatry
影响因子：
13.3
作者：
Stoddard,Joel;Wiggins,JillianLee;Wakschlag,LaurenS
通讯作者：
Wakschlag,LaurenS

Clinical Affective Neuroscience.

临床情感神经科学。

DOI：
10.1016/j.jaac.2018.07.877
发表时间：
2018
期刊：
Journal of the American Academy of Child and Adolescent Psychiatry
影响因子：
13.3
作者：
Penner,AnneE;Stoddard,Joel
通讯作者：
Stoddard,Joel

Finding the Neural Basis of Pediatric Posttraumatic Stress Disorder.

寻找小儿创伤后应激障碍的神经基础。

DOI：
10.1016/j.bpsc.2018.12.009
发表时间：
2019
期刊：
Biological psychiatry. Cognitive neuroscience and neuroimaging
影响因子：
0
作者：
Stoddard,Joel
通讯作者：
Stoddard,Joel

Editors' Note and Special Communication: Research Priorities in Child and Adolescent Mental Health Emerging From the COVID-19 Pandemic.

DOI：
10.1016/j.jaac.2021.03.005
发表时间：
2021-05
期刊：
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
影响因子：
13.3
作者：
Novins, Douglas K.;Stoddard, Joel;Althoff, Robert R.;Charach, Alice;Cortese, Samuele;Cullen, Kathryn Regan;Frazier, Jean A.;Glatt, Stephen J.;Henderson, Schuyler W.;Herringa, Ryan J.;Hulvershorn, Leslie;Kieling, Christian;McBride, Anne B.;McCauley, Elizabeth;Middeldorp, Christel M.;Reiersen, Angela M.;Rockhill, Carol M.;Sagot, Adam J.;Scahill, Lawrence;Simonoff, Emily;Stewart, S. Evelyn;Szigethy, Eva;Taylor, Jerome H.;White, Tonya;Zima, Bonnie T.
通讯作者：
Zima, Bonnie T.

Editorial: Linking Emotional and Behavioral Dysregulation in Adolescents to Regulatory Cortex.

社论：将青少年的情绪和行为失调与调节皮层联系起来。