Racial Differences in Serum Sodium and Blood Pressure Regulation

血清钠和血压调节的种族差异

基本信息

批准号：
10004724
负责人：
Austin Tyler Robinson
金额：
$ 14.57万
依托单位：
AUBURN UNIVERSITY AT AUBURN
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10004724
关键词：
Acute Adult Adverse event Aldosterone American Arteries Baroreflex Biological Availability Blood Circulation Blood Pressure Blood Vessels Buffers Cardiovascular Physiology Cardiovascular system Chronic Consequentialism Coronary heart disease Data Delaware Development Plans Diet Dietary Sodium Discipline of Nursing Endothelium Environment Epidemiologist Epidemiology Exhibits Fibrinogen Funding Hypertension Impairment Individual Inflammation Inflammatory Infusion procedures Intake International Intervention Journals Life Style Mental Health Mentors Mentorship Multi-Ethnic Study of Atherosclerosis National Heart, Lung, and Blood Institute Nerve Neuropsychology Nitric Oxide Outcome Oxidative Stress Physical activity Physiology Plasma Prevention strategy Publishing Race Reactive Oxygen Species Renin Research Research Personnel Rest Role Saline Sampling Serum Signal Transduction Sleep Sleep Deprivation Sodium Sodium Chloride Stroke Testing Training Translating Universities Vascular Diseases Vasoconstrictor Agents Vasodilator Agents Whole Blood Work austin blood pressure regulation cardiometabolism cardiovascular health career development comorbidity cytokine dietary salt endothelial dysfunction feeding insight large datasets lifestyle factors male meetings multidisciplinary neurovascular nutrition professor racial difference racial disparity response salt intake salt sensitive salt sensitive hypertension senior faculty skills sleep health treatment strategy

项目摘要

PROJECT SUMMARY / ABSTRACT CANDIDATE: Austin T. Robinson, Ph.D is a Postdoctoral Associate at the University of Delaware (UD). Dr. Robinson aims to study racial differences in cardiovascular responses to high dietary sodium (Na+). He recently published data demonstrating that compared to white individuals, 1) black individuals have augmented increases in serum Na+ to a hypertonic saline infusion; and 2) exhibit higher blood pressure (BP) for a given serum Na+. In this proposal, he will translate these findings by comprehensively assessing neurovascular responses to acute (single meal) and chronic (10 days of a controlled feeding) high dietary Na+. The central hypothesis is that high dietary Na+ influences sympathetic nerve activity similarly in black and white individuals; however, diminished vasodilator capacity and augmented sympathetic transduction (vasoconstrictor responses to sympathetic nerve bursts) contribute to exaggerated BP dysregulation in black individuals. He will also determine the role of lifestyle factors (i.e., sleep, physical activity, and nutrition) on potential baseline racial differences in CV physiology. CAREER DEVELOPMENT PLAN: Dr. Robinson proposes to enhance his career development by: 1) Acquiring new skills in the assessment of sleep, assessment of (nitric oxide) NO. bioavailability, and assessment of reactive oxygen species (ROS). 2) Advanced training in epidemiology to analyze large data sets. Specifically, he will perform secondary data of samples collected for the Multi-Ethnic Study of Atherosclerosis (MESA) under the guidance of advisor Dr. Norrina Allen, an expert epidemiologist. 3) Refining his professional skills though formal course work, attendance and presentations at weekly journal clubs, and at national/international scientific meetings. ENVIRONMENT: Dr. Robinson will train in an outstanding research environment supported by a multi- disciplinary team of mentors. The primary mentor, Dr. Farquhar, is an NHLBI-funded full professor at UD with a record of successful mentorship. He is an expert in autonomic control of circulation, and executing controlled salt feeding studies. Co-mentor Dr. Edwards is also at UD and a leading expert in vascular physiology function and executing controlled dietary salt feeding studies. Co-mentor Dr. Brown is an expert in lifestyle as a preventive and treatment strategy for hypertension and vascular function in black individuals. Advisors Dr. Zimmerman and Dr. Poole are experts in ROS and NO. signaling, respectively. Advisor Dr. Buxton is a recognized expert in sleep and health consequences of sleep deficiency, especially cardiometabolic outcomes. Advisor Dr. Wright is a professor in Nursing at UD and has expertise in neuropsychology and racial disparities. RESEARCH: Black individuals are more prone to salt-sensitive elevations in BP and adverse cardiovascular conditions associated with chronic high dietary Na+ intake compared to other racial groups. Racial disparities in vascular function and, autonomic control of BP in black individuals under basal conditions also exist. There is a critical need to elucidate the physiology underlying these racial disparities and to determine if these racial disparities are attributable to lifestyle differences.

项目概要/摘要候选人：Austin T. Robinson 博士是特拉华大学 (UD) 的博士后。博士。罗宾逊旨在研究心血管对高钠 (Na+) 反应的种族差异。他最近公布的数据表明，与白人相比，1）黑人的增幅有所增加血清 Na+ 输注高渗盐水； 2) 对于给定的血清 Na+，表现出较高的血压 (BP)。在在这项提议中，他将通过全面评估神经血管对急性发作的反应来转化这些发现（单餐）和慢性（10 天的控制喂养）高饮食 Na+。中心假设是高饮食中的 Na+ 对黑人和白人的交感神经活动的影响相似；然而减少了血管舒张能力和增强的交感神经传导（对交感神经的血管收缩反应）爆发）会导致黑人血压失调。他还将确定生活方式的作用影响心血管生理学潜在基线种族差异的因素（即睡眠、体力活动和营养）。职业发展计划：Robinson 博士建议通过以下方式加强他的职业发展： 1) 获得评估睡眠的新技能，评估（一氧化氮）NO。生物利用度和反应性评估氧物质（ROS）。 2) 流行病学分析大数据集的高级培训。具体来说，他将执行为动脉粥样硬化多种族研究 (MESA) 收集的样本的二次数据顾问流行病学家 Norrina Allen 博士的指导。 3）通过正式的方式提高他的专业技能每周期刊俱乐部以及国家/国际科学会议的课程作业、出勤和演讲会议。环境：罗宾逊博士将在由多方支持的出色研究环境中接受培训纪律导师团队。主要导师 Farquhar 博士是由 NHLBI 资助的 UD 正教授，拥有成功指导的记录。他是循环自主控制和执行受控方面的专家盐喂养研究。联合导师 Edwards 博士也是 UD 的血管生理学功能领域的领先专家并进行受控膳食盐喂养研究。共同导师布朗博士是生活方式预防方面的专家黑人高血压和血管功能的治疗策略。顾问齐默尔曼博士和 Poole 博士是 ROS 和 NO 方面的专家。分别发出信号。顾问巴克斯顿博士是公认的睡眠专家以及睡眠不足对健康的影响，尤其是心脏代谢结果。顾问赖特博士是特拉华大学护理学教授，拥有神经心理学和种族差异方面的专业知识。研究：黑色个体更容易出现对盐敏感的血压升高和相关的不良心血管疾病与其他种族群体相比，长期膳食钠摄入量较高。血管功能的种族差异，黑人个体在基础条件下对血压的自主控制也存在。迫切需要阐明这些种族差异背后的生理学，并确定这些种族差异是否可归因于生活方式的差异。