Racial Differences in Serum Sodium and Blood Pressure Regulation

血清钠和血压调节的种族差异

• 批准号: 10004724
• 负责人: Austin Tyler Robinson
• 金额: $ 14.57万
• 依托单位: AUBURN UNIVERSITY AT AUBURN
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10004724
• 关键词: Acute; Adult; Adverse event; Aldosterone; American; Arteries; Baroreflex; Biological Availability; Blood Circulation; Blood Pressure; Blood Vessels; Buffers; Cardiovascular Physiology; Cardiovascular system; Chronic; Consequentialism; Coronary heart disease; Data; Delaware; Development Plans; Diet; Dietary Sodium; Discipline of Nursing; Endothelium; Environment; Epidemiologist; Epidemiology; Exhibits; Fibrinogen; Funding; Hypertension; Impairment; Individual; Inflammation; Inflammatory; Infusion procedures; Intake; International; Intervention; Journals; Life Style; Mental Health; Mentors; Mentorship; Multi-Ethnic Study of Atherosclerosis; National Heart, Lung, and Blood Institute; Nerve; Neuropsychology; Nitric Oxide; Outcome; Oxidative Stress; Physical activity; Physiology; Plasma; Prevention strategy; Publishing; Race; Reactive Oxygen Species; Renin; Research; Research Personnel; Rest; Role; Saline; Sampling; Serum; Signal Transduction; Sleep; Sleep Deprivation; Sodium; Sodium Chloride; Stroke; Testing; Training; Translating; Universities; Vascular Diseases; Vasoconstrictor Agents; Vasodilator Agents; Whole Blood; Work; austin; blood pressure regulation; cardiometabolism; cardiovascular health; career development; comorbidity; cytokine; dietary salt; endothelial dysfunction; feeding; insight; large datasets; lifestyle factors; male; meetings; multidisciplinary; neurovascular; nutrition; professor; racial difference; racial disparity; response; salt intake; salt sensitive; salt sensitive hypertension; senior faculty; skills; sleep health; treatment strategy

PROJECT SUMMARY / ABSTRACT CANDIDATE: Austin T. Robinson, Ph.D is a Postdoctoral Associate at the University of Delaware (UD). Dr. Robinson aims to study racial differences in cardiovascular responses to high dietary sodium (Na+). He recently published data demonstrating that compared to white individuals, 1) black individuals have augmented increases in serum Na+ to a hypertonic saline infusion; and 2) exhibit higher blood pressure (BP) for a given serum Na+. In this proposal, he will translate these findings by comprehensively assessing neurovascular responses to acute (single meal) and chronic (10 days of a controlled feeding) high dietary Na+. The central hypothesis is that high dietary Na+ influences sympathetic nerve activity similarly in black and white individuals; however, diminished vasodilator capacity and augmented sympathetic transduction (vasoconstrictor responses to sympathetic nerve bursts) contribute to exaggerated BP dysregulation in black individuals. He will also determine the role of lifestyle factors (i.e., sleep, physical activity, and nutrition) on potential baseline racial differences in CV physiology. CAREER DEVELOPMENT PLAN: Dr. Robinson proposes to enhance his career development by: 1) Acquiring new skills in the assessment of sleep, assessment of (nitric oxide) NO. bioavailability, and assessment of reactive oxygen species (ROS). 2) Advanced training in epidemiology to analyze large data sets. Specifically, he will perform secondary data of samples collected for the Multi-Ethnic Study of Atherosclerosis (MESA) under the guidance of advisor Dr. Norrina Allen, an expert epidemiologist. 3) Refining his professional skills though formal course work, attendance and presentations at weekly journal clubs, and at national/international scientific meetings. ENVIRONMENT: Dr. Robinson will train in an outstanding research environment supported by a multi- disciplinary team of mentors. The primary mentor, Dr. Farquhar, is an NHLBI-funded full professor at UD with a record of successful mentorship. He is an expert in autonomic control of circulation, and executing controlled salt feeding studies. Co-mentor Dr. Edwards is also at UD and a leading expert in vascular physiology function and executing controlled dietary salt feeding studies. Co-mentor Dr. Brown is an expert in lifestyle as a preventive and treatment strategy for hypertension and vascular function in black individuals. Advisors Dr. Zimmerman and Dr. Poole are experts in ROS and NO. signaling, respectively. Advisor Dr. Buxton is a recognized expert in sleep and health consequences of sleep deficiency, especially cardiometabolic outcomes. Advisor Dr. Wright is a professor in Nursing at UD and has expertise in neuropsychology and racial disparities. RESEARCH: Black individuals are more prone to salt-sensitive elevations in BP and adverse cardiovascular conditions associated with chronic high dietary Na+ intake compared to other racial groups. Racial disparities in vascular function and, autonomic control of BP in black individuals under basal conditions also exist. There is a critical need to elucidate the physiology underlying these racial disparities and to determine if these racial disparities are attributable to lifestyle differences.

项目摘要 /摘要 候选人：Austin T. Robinson，博士是特拉华大学（UD）的博士后同学。博士 鲁滨逊旨在研究对高饮食钠（NA​​+）的心血管反应的种族差异。他最近 已发布的数据表明，与白人相比，1）黑人个体增加了增长 在高渗盐水输注的血清Na+中； 2）对于给定的血清Na+表现出较高的血压（BP）。在 这项建议，他将通过全面评估神经血管对急性的反应来翻译这些发现 （单餐）和慢性（受控喂养的10天）高饮食NA+。中心假设是 饮食NA+在黑人和白人中类似地影响交感神经活动；但是，减少了 血管扩张剂的能力和增强的交感神经转导（血管收缩对交感神经的反应 爆发）导致黑人个体夸大的BP失调。他还将确定生活方式的作用 CV生理学潜在的基线种族差异的因素（即睡眠，体育锻炼和营养）。 职业发展计划：鲁滨逊博士提议通过以下方式增强他的职业发展：1） 评估睡眠的新技能，评估（一氧化氮）编号。生物利用度和反应性评估 氧（ROS）。 2）流行病学的高级培训以分析大型数据集。具体来说，他会的 对收集的样品进行辅助数据，以进行动脉粥样硬化的多种族研究（MESA） 专家流行病学专家Norrina Allen博士的指导。 3）精炼他的专业技能虽然正式 每周期刊俱乐部以及国家/国际科学的课程工作，出勤和演讲 会议。环境：鲁滨逊博士将在出色的研究环境中进行培训 纪律导师团队。主要导师Farquhar博士是UD的NHLBI资助的完整教授 成功指导的记录。他是循环自主控制和执行受控的专家 盐喂养研究。 Edwards博士也是UD，并且是血管生理功能领域的领先专家 并执行受控的饮食盐喂养研究。联合委托人布朗博士是生活方式的专家，作为预防性 以及黑人个体高血压和血管功能的治疗策略。顾问Zimmerman博士和 普尔博士是ROS的专家，没有。信号分别。顾问巴克斯顿博士是公认的睡眠专家 睡眠不足的健康后果，尤其是心脏代谢结果。顾问赖特博士是 UD护理学教授，在神经心理学和种族差异方面具有专业知识。研究：黑色 个体更容易在BP和不良心血管疾病中对盐敏感的海拔 与其他种族群体相比，慢性饮食NA+摄入量具有慢性高饮食。血管功能的种族差异， 在基础条件下，黑人个体对BP的自主控制也存在。阐明的迫切需要 这些种族差异的基础生理学，并确定这些种族差异是否归因于 生活方式差异。