BLR&D Research Career Scientist Application

BLR

基本信息

批准号：
10047700
负责人：
Timothy S Kern
金额：
--
依托单位：
VETERANS HEALTH ADMINISTRATION
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-10-01 至 2021-09-30
项目状态：
已结题

项目摘要

Diabetic retinopathy remains the leading cause of visual loss in adults in the US, and it is increasing throughout the US and the world as diabetes rapidly affects more people. Although prolonged good glycemic control has been demonstrated to inhibit the development of diabetic retinopathy in patients, this goal is essentially impossible for most diabetics to maintain, so additional means are needed to inhibit the development of diabetic retinopathy. The Kern laboratory focuses on how diabetic retinopathy develops and thus can be inhibited. This research currently focuses on 4 research areas related to the development of diabetic retinopathy, most of which initially were reported by or championed by Dr. Kern and his collaborators: (1) the role of leukocytes and inflammation as a cause of diabetic retinopathy, and the regulation of those pro-inflammatory changes by epigenetic acetylation, (2) the role of retinal photoreceptor cells and vision itself in the development of the retinal vascular leakage and degeneration of diabetic retinopathy, (3) the use of low intensity light to inhibit and reverse diabetic retinopathy, and (4) the use of systems pharmacology of G-Protein Coupled Receptors to inhibit the retinopathy. Discussions are now underway to translate these findings into patients with diabetes.

糖尿病视网膜病变仍然是美国成年人视力丧失的主要原因，而且这一数字还在不断增加随着糖尿病迅速影响到更多的人，该病在美国和世界范围内迅速蔓延。虽然长期好血糖控制已被证明可以抑制患者糖尿病视网膜病变的发展，对于大多数糖尿病患者来说，这个目标基本上是不可能维持的，因此需要额外的手段来实现抑制糖尿病视网膜病变的发展。克恩实验室专注于研究糖尿病如何视网膜病变发生并因此可以被抑制。本研究目前主要集中在4个研究领域与糖尿病视网膜病变的发展有关，其中大部分最初是由或由 Kern 博士及其合作者倡导：（1）白细胞和炎症作为导致糖尿病视网膜病变，以及通过表观遗传乙酰化调节这些促炎症变化， (2)视网膜感光细胞和视觉本身在视网膜血管发育中的作用糖尿病视网膜病变的渗漏和变性，（3）利用低强度光抑制和逆转糖尿病视网膜病变，以及（4）利用 G 蛋白偶联受体的系统药理学来抑制视网膜病变。目前正在讨论将这些发现应用于糖尿病患者。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Presence of retinal pericyte-reactive autoantibodies in diabetic retinopathy patients.

DOI：
10.1038/srep20341
发表时间：
2016-02-03
期刊：
Scientific reports
影响因子：
4.6
作者：
Zhang L;Li Y;Payne J;Srivastava S;Fan X;Fung J;Li X;Kern TS;Lin F
通讯作者：
Lin F

Formulation and efficacy of ECO/pRHO-ABCA4-SV40 nanoparticles for nonviral gene therapy of Stargardt disease in a mouse model.

DOI：
10.1016/j.jconrel.2020.12.010
发表时间：
2021-02-10
期刊：
JOURNAL OF CONTROLLED RELEASE
影响因子：
10.8
作者：
Sun, Da;Sun, Wenyu;Gao, Song-Qi;Wei, Cheng;Naderi, Amirreza;Schilb, Andrew L.;Scheidt, Josef;Lee, Sangjoon;Kern, Timothy S.;Palczewski, Krzysztof;Lu, Zheng-Rong
通讯作者：
Lu, Zheng-Rong

ICAM-1 on the luminal surface of endothelial cells is induced to a greater extent in mouse retina than in other tissues in diabetes.

DOI：
10.1007/s00125-022-05719-0
发表时间：
2022-10
期刊：
DIABETOLOGIA
影响因子：
8.2
作者：
Lessieur, Emma M.;Liu, Haitao;Saadane, Aicha;Du, Yunpeng;Kiser, Jianying;Kern, Timothy S.
通讯作者：
Kern, Timothy S.

Diabetes of 5 years duration does not lead to photoreceptor degeneration in the canine non-tapetal inferior-nasal retina.

持续 5 年的糖尿病不会导致犬非绒毡层下鼻视网膜感光细胞变性。