Identifying the role of emotion processes in core features of Autism Spectrum Disorder

识别情绪过程在自闭症谱系障碍核心特征中的作用

• 批准号: 10001024
• 负责人: Vanessa Hus Bal
• 金额: $ 18.23万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-05 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10001024
• 关键词: 12 year old; Affect; Affective; Age; Alzheimer' s Disease; Animal Model; Area; Autonomic nervous system; Basic Science; Behavior; Behavioral; Biological; Brain; Breathing; California; Cardiac; Child; Clinical; Clinical Research; Collection; Complex; Conscious; Data; Depressed mood; Development; Disease; Emotional; Emotional Stability; Emotions; Face; Facial Expression; Facial Muscles; Failure; Familiarity; Fostering; Foundations; Frontotemporal Dementia; Functional disorder; Future; Generations; Goals; Impairment; Individual; Instruction; Intellectual functioning disability; Interdisciplinary Study; Investigation; Knowledge; Laboratories; Laboratory Finding; Learning; Link; Longevity; Longitudinal Studies; Maintenance; Major Depressive Disorder; Measurement; Measures; Mediating; Mental disorders; Mentors; Methodology; Methods; Mission; Motivation; National Institute of Mental Health; Neurobiology; Neurodevelopmental Disorder; Neurologist; Outcome; Patient Self-Report; Patients; Physiological; Population; Process; Psychiatrist; Psychiatry; Psychologist; Psychometrics; Psychopathology; Psychophysiology; Public Health; Reaction; Regulation; Research; Role; San Francisco; Science; Scientist; Social Behavior; Social Functioning; Social Interaction; Stimulus; Symptoms; System; Time; Training; Translating; Universities; Virginia; Withdrawal; animal model development; autism spectrum disorder; autistic children; base; career; clinical phenotype; clinical translation; cognitive function; emotion dysregulation; emotion regulation; experience; genetic risk factor; improved; innovation; interest; multidisciplinary; multilevel analysis; new therapeutic target; patient oriented research; positive emotional state; preservation; professor; programs; relating to nervous system; respiratory; response; skills; social; social attachment; social skills; therapy development

PROJECT SUMMARY / ABSTRACT This is a K23 application for Dr. Vanessa H. Bal, an Assistant Professor in Psychiatry at the University of California San Francisco. Dr. Bal is establishing herself as a clinician-scientist who conducts interdisciplinary, patient-oriented research aimed at advancing understanding of the biological bases of Autism Spectrum Disorder (ASD) symptoms. This K23 will provide Dr. Bal with essential support to accomplish the following goals: 1) develop expertise in the theoretical basis of affective science; 2) gain methodological proficiency (collection and analysis of psychophysiological and facial behavior data) to conduct future emotion studies in children with ASD across the range of ability (e.g., minimally verbal); 3) gain familiarity with the neural systems mediating emotion processes; 4) obtain the knowledge necessary to use laboratory-based findings to understand mechanisms underlying clinical measures of socioemotional impairments; 5) learn to translate clinical phenotypes to animal model and treatment development studies; 6) acquire knowledge needed to conduct longitudinal research with neurodevelopmental populations; and 7) develop an independent interdisciplinary research career. To achieve these goals, Dr. Bal has assembled a multidisciplinary mentoring team including a primary mentor: Dr. Howard Rosen (a neurologist with expertise in psychophysiology and the organization of emotional systems in the brain); four co-mentors: Drs. Virginia Sturm (a neuropsychologist with expertise in laboratory assessment of emotion and social behavior in patients), Stephen Hinshaw (a psychologist with expertise in developmental psychopathology and longitudinal studies of neurodevelopmental disorders), and Matthew State (a psychiatrist and geneticist with expertise in interdisciplinary ASD research); and a statistical advisor, Dr. Kevin Delucchi (a biostatistician with expertise in psychiatric research). The proposed project explores the relationship between emotional processes (reactivity and regulation) and socioemotional dysfunction in ASD. Dr. Bal will use laboratory-based paradigms to measure physiological (cardiac, respiratory, electrodermal) and behavioral (facial muscles) emotional reactivity and regulation in child- ren with ASD and typically development (Aims 1 & 2). She will then integrate laboratory findings with clinical measures of socioemotional functioning and ASD symptoms to determine the real-world impact of emotional impairments (Aim 3). The goal of Dr. Bal's research is to identify mechanisms underlying socioemotional impairments that can be used to delineate associations between genetic risk factors and clinical outcomes. This project is innovative because it explores the potential role of emotion processing in ASD symptoms, using well-established, translational methods from affective science that have clarified mechanisms underlying clinical impairments in other patient groups. Results will significantly contribute to our understanding of the biological basis of ASD symptoms. Dr. Bal's K23 training will prepare her to conduct cutting-edge studies of aberrant socioemotional development across the lifespan that will inform clinical and basic ASD research.

项目摘要 /摘要 这是K23的申请，用于凡妮莎·H·巴尔博士，他是大学精神病学助理教授 加利福尼亚旧金山。 Bal博士正在建立自己是临床医生，他进行跨学科的人， 面向患者的研究旨在促进对自闭症谱系生物学基础的理解 疾病（ASD）症状。该K23将为BAL博士提供基本的支持，以完成以下内容 目标：1）在情感科学的理论基础上发展专业知识； 2）获得方法学水平 （对心理生理和面部行为数据的收集和分析）在进行未来的情感研究 具有ASD范围范围的ASD的儿童（例如，言语最少）； 3）熟悉神经系统 调解情绪过程； 4）获取使用基于实验室发现的必要知识 了解社会情感障碍临床措施的基础机制； 5）学会翻译 动物模型和治疗发展研究的临床表型； 6）获取所需的知识 通过神经发育人群进行纵向研究； 7）建立独立 跨学科研究职业。为了实现这些目标，BAL博士聚集了多学科指导 包括主要导师在内的团队：霍华德·罗森博士（一名具有心理生理​​学专业知识的神经科医生， 大脑中情绪系统的组织）；四个副官员：博士。弗吉尼亚·斯特姆（Virginia Sturm）（一名神经心理学家 斯蒂芬·辛肖（Stephen Hinshaw）对患者情绪和社会行为的实验室评估专业知识 心理学家具有发育心理病理学和神经发育纵向研究的专业知识 疾病）和马修·州立大学（Matthew State）（在跨学科ASD研究方面具有专业知识的精神病医生和遗传学家）； 以及统计顾问Kevin Delucchi博士（具有精神病研究专业知识的生物统计学家）。 拟议的项目探讨了情绪过程（反应性和调节）之间的关系 和ASD的社会情感功能障碍。 BAL博士将使用基于实验室的范例来测量生理 （心脏，呼吸，电甲型）和行为（面部肌肉）的情绪反应性和儿童的调节 REN具有ASD，通常是开发（目标1和2）。然后，她将将实验室发现与临床结合 社会情感功能和ASD症状的度量，以确定情绪的现实影响 障碍（目标3）。 BAL博士研究的目的是确定社会情感的基础机制 可用于描述遗传危险因素和临床结果之间关联的障碍。 该项目具有创新性，因为它探讨了情感处理在ASD症状中的潜在作用， 情感科学的建立良好的翻译方法，这些方法阐明了基础的机制 其他患者组的临床障碍。结果将极大地有助于我们对 ASD症状的生物基础。 BAL博士的K23培训将使她准备对 整个生命周期中的异常社会情感发展将为临床和基本的ASD研究提供依据。

项目成果

Advancing Mental Health Supports for Autistic Postsecondary Students: A Call for Research.

• DOI: 10.1089/aut.2020.0044
• 发表时间: 2021-03
• 期刊: Autism in adulthood : challenges and management
• 作者: Gunin GB;Gravino A;Bal VH
• 通讯作者: Bal VH

Parent-Reported Suicidal Ideation in Three Population-Based Samples of School-Aged Korean Children With Autism Spectrum Disorder and Autism Spectrum Screening Questionnaire Screen Positivity.

• DOI: 10.1080/13811118.2020.1868367
• 发表时间: 2022-07
• 期刊: ARCHIVES OF SUICIDE RESEARCH
• 影响因子: 2.8
• 作者: Bal, Vanessa H.;Leventhal, Bennett L.;Carter, Gregory;Kim, Hosanna;Koh, Yun-Joo;Ha, Mina;Kwon, Ho-Jang;Hong, Patricia;Kim, Young Shin
• 通讯作者: Kim, Young Shin

Associations between co-occurring conditions and age of autism diagnosis: Implications for mental health training and adult autism research.

• DOI: 10.1002/aur.2808
• 发表时间: 2022-11
• 期刊: AUTISM RESEARCH
• 影响因子: 4.7
• 作者: Jadav, Nikita;Bal, Vanessa H.
• 通讯作者: Bal, Vanessa H.

Early Pandemic Experiences of Autistic Adults: Predictors of Psychological Distress.

• DOI: 10.1002/aur.2480
• 发表时间: 2021-06
• 期刊: Autism research : official journal of the International Society for Autism Research
• 作者: Bal VH;Wilkinson E;White LC;Law JK;SPARK Consortium;Feliciano P;Chung WK
• 通讯作者: Chung WK

Measurement of subcategories of repetitive behaviors in autistic adolescents and adults.

自闭症青少年和成人重复行为子类别的测量。

• DOI: 10.1089/aut.2019.0056
• 发表时间: 2020
• 期刊: Autism in adulthood : challenges and management
• 作者: McDermott,CourtneyR;Farmer,Cristan;Gotham,KatherineO;Bal,VanessaH
• 通讯作者: Bal,VanessaH