Identifying the role of emotion processes in core features of Autism Spectrum Disorder

识别情绪过程在自闭症谱系障碍核心特征中的作用

基本信息

批准号：
10001024
负责人：
Vanessa Hus Bal
金额：
$ 18.23万
依托单位：
RUTGERS, THE STATE UNIV OF N.J.
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-05 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10001024
关键词：
12 year old Affect Affective Age Alzheimer&apos s Disease Animal Model Area Autonomic nervous system Basic Science Behavior Behavioral Biological Brain Breathing California Cardiac Child Clinical Clinical Research Collection Complex Conscious Data Depressed mood Development Disease Emotional Emotional Stability Emotions Face Facial Expression Facial Muscles Failure Familiarity Fostering Foundations Frontotemporal Dementia Functional disorder Future Generations Goals Impairment Individual Instruction Intellectual functioning disability Interdisciplinary Study Investigation Knowledge Laboratories Laboratory Finding Learning Link Longevity Longitudinal Studies Maintenance Major Depressive Disorder Measurement Measures Mediating Mental disorders Mentors Methodology Methods Mission Motivation National Institute of Mental Health Neurobiology Neurodevelopmental Disorder Neurologist Outcome Patient Self-Report Patients Physiological Population Process Psychiatrist Psychiatry Psychologist Psychometrics Psychopathology Psychophysiology Public Health Reaction Regulation Research Role San Francisco Science Scientist Social Behavior Social Functioning Social Interaction Stimulus Symptoms System Time Training Translating Universities Virginia Withdrawal animal model development autism spectrum disorder autistic children base career clinical phenotype clinical translation cognitive function emotion dysregulation emotion regulation experience genetic risk factor improved innovation interest multidisciplinary multilevel analysis new therapeutic target patient oriented research positive emotional state preservation professor programs relating to nervous system respiratory response skills social social attachment social skills therapy development

项目摘要

PROJECT SUMMARY / ABSTRACT This is a K23 application for Dr. Vanessa H. Bal, an Assistant Professor in Psychiatry at the University of California San Francisco. Dr. Bal is establishing herself as a clinician-scientist who conducts interdisciplinary, patient-oriented research aimed at advancing understanding of the biological bases of Autism Spectrum Disorder (ASD) symptoms. This K23 will provide Dr. Bal with essential support to accomplish the following goals: 1) develop expertise in the theoretical basis of affective science; 2) gain methodological proficiency (collection and analysis of psychophysiological and facial behavior data) to conduct future emotion studies in children with ASD across the range of ability (e.g., minimally verbal); 3) gain familiarity with the neural systems mediating emotion processes; 4) obtain the knowledge necessary to use laboratory-based findings to understand mechanisms underlying clinical measures of socioemotional impairments; 5) learn to translate clinical phenotypes to animal model and treatment development studies; 6) acquire knowledge needed to conduct longitudinal research with neurodevelopmental populations; and 7) develop an independent interdisciplinary research career. To achieve these goals, Dr. Bal has assembled a multidisciplinary mentoring team including a primary mentor: Dr. Howard Rosen (a neurologist with expertise in psychophysiology and the organization of emotional systems in the brain); four co-mentors: Drs. Virginia Sturm (a neuropsychologist with expertise in laboratory assessment of emotion and social behavior in patients), Stephen Hinshaw (a psychologist with expertise in developmental psychopathology and longitudinal studies of neurodevelopmental disorders), and Matthew State (a psychiatrist and geneticist with expertise in interdisciplinary ASD research); and a statistical advisor, Dr. Kevin Delucchi (a biostatistician with expertise in psychiatric research). The proposed project explores the relationship between emotional processes (reactivity and regulation) and socioemotional dysfunction in ASD. Dr. Bal will use laboratory-based paradigms to measure physiological (cardiac, respiratory, electrodermal) and behavioral (facial muscles) emotional reactivity and regulation in child- ren with ASD and typically development (Aims 1 & 2). She will then integrate laboratory findings with clinical measures of socioemotional functioning and ASD symptoms to determine the real-world impact of emotional impairments (Aim 3). The goal of Dr. Bal's research is to identify mechanisms underlying socioemotional impairments that can be used to delineate associations between genetic risk factors and clinical outcomes. This project is innovative because it explores the potential role of emotion processing in ASD symptoms, using well-established, translational methods from affective science that have clarified mechanisms underlying clinical impairments in other patient groups. Results will significantly contribute to our understanding of the biological basis of ASD symptoms. Dr. Bal's K23 training will prepare her to conduct cutting-edge studies of aberrant socioemotional development across the lifespan that will inform clinical and basic ASD research.

项目概要/摘要这是 Vanessa H. Bal 博士的 K23 申请，她是纽约大学精神病学助理教授。加利福尼亚州旧金山。 Bal 博士正在将自己打造成一名临床医生科学家，从事跨学科、以患者为中心的研究，旨在增进对自闭症谱系生物学基础的理解障碍 (ASD) 症状。该 K23 将为 Bal 博士提供必要的支持，以完成以下任务目标：1）发展情感科学理论基础方面的专业知识； 2）获得方法论熟练程度（收集和分析心理生理和面部行为数据）以进行未来的情绪研究患有自闭症谱系障碍（ASD）的儿童的能力范围不一（例如，言语能力最低）； 3）熟悉神经系统调解情绪过程； 4) 获得使用基于实验室的研究结果所需的知识了解社会情绪障碍临床测量的潜在机制； 5）学习翻译动物模型的临床表型和治疗开发研究； 6) 获得所需的知识对神经发育人群进行纵向研究； 7) 开发独立的跨学科研究生涯。为了实现这些目标，巴尔博士组建了多学科指导团队团队包括主要导师：Howard Rosen 博士（一位神经科医生，在心理生理学和大脑中情感系统的组织）；四位共同导师：博士。弗吉尼亚·斯特姆（Virginia Sturm）（一位神经心理学家患者情绪和社会行为实验室评估方面的专业知识），Stephen Hinshaw（具有发展精神病理学和神经发育纵向研究专业知识的心理学家障碍）和 Matthew State（精神病学家和遗传学家，具有跨学科自闭症谱系障碍研究的专业知识）；以及统计顾问 Kevin Delucchi 博士（一位拥有精神病学研究专业知识的生物统计学家）。拟议的项目探讨了情绪过程（反应性和调节）之间的关系和自闭症谱系障碍（ASD）中的社会情绪功能障碍。 Bal 博士将使用基于实验室的范例来测量生理学儿童的（心脏、呼吸、皮肤电）和行为（面部肌肉）情绪反应和调节患有 ASD 的人和典型的发展（目标 1 和 2）。然后她会将实验室发现与临床相结合社会情绪功能和自闭症谱系障碍症状的测量，以确定情绪对现实世界的影响损害（目标 3）。 Bal 博士的研究目标是确定社会情绪的潜在机制可用于描述遗传风险因素与临床结果之间关联的损伤。该项目具有创新性，因为它探索了情绪处理在自闭症谱系障碍症状中的潜在作用，利用来自情感科学的完善的转化方法，阐明了潜在的机制其他患者群体的临床损伤。结果将极大地有助于我们理解 ASD 症状的生物学基础。 Bal 博士的 K23 培训将为她进行前沿研究做好准备整个生命周期中异常的社会情感发展将为临床和基础自闭症谱系障碍研究提供信息。

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Advancing Mental Health Supports for Autistic Postsecondary Students: A Call for Research.

DOI：
10.1089/aut.2020.0044
发表时间：
2021-03
期刊：
Autism in adulthood : challenges and management
影响因子：
0
作者：
Gunin GB;Gravino A;Bal VH
通讯作者：
Bal VH

Parent-Reported Suicidal Ideation in Three Population-Based Samples of School-Aged Korean Children With Autism Spectrum Disorder and Autism Spectrum Screening Questionnaire Screen Positivity.

DOI：
10.1080/13811118.2020.1868367
发表时间：
2022-07
期刊：
ARCHIVES OF SUICIDE RESEARCH
影响因子：
2.8
作者：
Bal, Vanessa H.;Leventhal, Bennett L.;Carter, Gregory;Kim, Hosanna;Koh, Yun-Joo;Ha, Mina;Kwon, Ho-Jang;Hong, Patricia;Kim, Young Shin
通讯作者：
Kim, Young Shin

Associations between co-occurring conditions and age of autism diagnosis: Implications for mental health training and adult autism research.

DOI：
10.1002/aur.2808
发表时间：
2022-11
期刊：
AUTISM RESEARCH
影响因子：
4.7
作者：
Jadav, Nikita;Bal, Vanessa H.
通讯作者：
Bal, Vanessa H.

Early Pandemic Experiences of Autistic Adults: Predictors of Psychological Distress.

DOI：
10.1002/aur.2480
发表时间：
2021-06
期刊：
Autism research : official journal of the International Society for Autism Research
影响因子：
0
作者：
Bal VH;Wilkinson E;White LC;Law JK;SPARK Consortium;Feliciano P;Chung WK
通讯作者：
Chung WK

Measurement of subcategories of repetitive behaviors in autistic adolescents and adults.

自闭症青少年和成人重复行为子类别的测量。