Development of semicircular canal prostheses for studies of vestibular plasticity

用于研究前庭可塑性的半规管假体的开发

• 批准号: 7545869
• 负责人: Daniel M Merfeld
• 金额: $ 31.67万
• 依托单位: MASSACHUSETTS EYE AND EAR INFIRMARY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7545869
• 关键词: 3-Dimensional; Acoustics; Address; American; Amplifiers; Anatomy; Animals; Biological Assay; Bypass; Chemicals; Chronic; Clinical; Cochlea; Cochlear Implants; Cues; Development; Devices; Dizziness; Drops; Ear; Electric Stimulation; Endolymph; Evoked Potentials; Eye Movements; Frequencies; Functional Magnetic Resonance Imaging; Hair Cells; Hearing Aids; Image; Impairment; Implant; Individual; Investigation; Lateral; Lead; Life; Liquid substance; Macaca mulatta; Masks; Measures; Mechanical Stimulation; Mechanics; Medical; Movement; NIH Program Announcements; Nature; Neurons; Operative Surgical Procedures; Optics; Organ; Patients; Perception; Peripheral; Physiological; Plastics; Process; Prosthesis; Relative (related person); Reporting; Research; Research Design; Research Personnel; Resolution; Rotation; Saimiri; Semicircular canal structure; Sensorineural Hearing Loss; Sensory; Signal Transduction; Spinal; Stimulus; Structure of posterior semicircular canal; Techniques; Testing; Time; Translations; United States National Institutes of Health; Work; Writing; awake; cellular transduction; design; equilibration disorder; experience; labyrinthectomy; medical attention; motor learning; neurotechnology; nonhuman primate; oculomotor; programs; relating to nervous system; research and development; response; vestibular prosthesis; visual feedback

Over 90 million Americans (>40%) will seek medical attention for dizziness or some other balance disorder sometime in their life. An NIH working committee has reported that at least 2 million Americans experience chronic impairment due to dizziness or other balance disorders, causing medical expenses in excess of $1 billion per year. Some of these patients could benefit from a vestibular prosthesis that would be similar to the cochlear implant used to treat profound sensorineural hearing loss. Our work developing vestibular prosthetics is limited by shortcomings in our understanding of vestibular plasticity, since we cannot assess if responses to chronic vestibular stimulation provided by our prosthesis are restricted by device limitations or if the plastic limitations observed experimentally are fundamental and physiologic in nature. Our understanding of vestibular plasticity is limited because the traditional techniques (e.g., chemical or surgical labyrinthectomy, canal plugging) that are available to chronically manipulate the vestibular signals are not controllable and/or reversible. To address these clinical and scientific limitations, we propose to develop a new prosthetic device that can be used chronically to stimulate a semicircular canal. Our proposal is written in direct response to program announcement PA-04-006 ("Neurotechnology Research Development & Enhancement"). The new device that we propose to develop will enable scientific investigations that are not possible using existing techniques while also fundamentally advancing vestibular prostheses. Specifically, we propose to design, develop, and test a new dynamic, chronic, controllable, fluid-dynamic, canal stimulator. This device combines microcontroller circuitry, like that developed for our vestibular prosthesis, with a chronic mechanical actuator that pushes endolymph in an individual semicircular canal, which, in turn, deflects the cupula. This device will provide chronic dynamic control of endolymph movement, which is an essential part of normal rotation transduction, to an individual canal such that the gain, dynamics, and/or the apparent anatomic plane of the implanted canal can be controllably altered in non-human primates. The device will even be capable of providing canal stimulation in the absence of rotation. We propose to use this device to perform four hypothesis-driven scientific investigations. Specifically, we propose: 1) to measure high-frequency (>50 Hz) VOR responses, 2) to measure VOR adaptation evoked by changes in the vestibular signals as opposed to the standard approach of providing changes in the visual feedback that guides VOR motor learning, 3) to measure evoked potentials to evaluate efficacy and stability of the peripheral vestibular stimulation being provided, 4) to investigate the influence of canal stimulation on tilt perception, directly testing the hypothesis that canal signals influence tilt perception.

超过 9000 万美国人 (>40%) 会因头晕或其他平衡障碍寻求医疗救助 他们生命中的某个时候。美国国立卫生研究院 (NIH) 工作委员会报告称，至少有 200 万美国人经历过 由于头晕或其他平衡障碍导致的慢性损伤，导致医疗费用超过 1 美元 每年十亿。其中一些患者可以受益于类似于前庭假体的前庭假体。 人工耳蜗用于治疗严重的感音神经性听力损失。我们的工作是开发前庭 假肢由于我们对前庭可塑性的理解存在缺陷而受到限制，因为我们无法评估是否 对我们的假体提供的慢性前庭刺激的反应受到设备限制的限制，或者如果 实验观察到的塑性限制本质上是基本的和生理性的。我们的理解 前庭可塑性的研究受到限制，因为传统技术（例如化学或外科手术） 迷路切除术、耳道堵塞术）可用于长期操纵前庭信号，但不 可控和/或可逆。为了解决这些临床和科学局限性，我们建议开发一种 可以长期使用以刺激半规管的新型假肢装置。我们的建议写成 直接响应计划公告 PA-04-006（“神经技术研究开发与 增强”）。我们建议开发的新设备将使科学研究成为可能 可以使用现有技术，同时从根本上改进前庭假体。具体来说， 我们建议设计、开发和测试一种新的动态、慢性、可控、流体动力学的运河 刺激器。该设备结合了微控制器电路，就像为我们的前庭假体开发的电路一样， 用一个慢性机械致动器推动单个半规管中的内淋巴，反过来， 使顶盖偏转。该装置将提供内淋巴运动的长期动态控制，这是一种 正常旋转传导的重要部分，到单个根管，使得增益、动态和/或 在非人类灵长类动物中，植入管的表观解剖平面可以可控地改变。这 该装置甚至能够在没有旋转的情况下提供根管刺激。我们建议使用这个 设备进行四项假设驱动的科学研究。具体来说，我们建议：1）测量 高频 (>50 Hz) VOR 响应，2) 测量由变化引起的 VOR 适应 前庭信号与提供视觉反馈变化的标准方法相反 指导 VOR 运动学习，3) 测量诱发电位以评估 VOR 运动的有效性和稳定性 提供外周前庭刺激，4) 研究耳道刺激对倾斜的影响 感知，直接检验运河信号影响倾斜感知的假设。

项目成果

Vestibuloocular reflex adaptation investigated with chronic motion-modulated electrical stimulation of semicircular canal afferents.

通过半规管传入的慢性运动调制电刺激研究前庭眼反射适应。

• 发表时间: 2010-02
• 影响因子: 2.5
• 作者: Lewis, Richard F;Haburcakova, Csilla;Gong, Wangsong;Makary, Chadi;Merfeld, Daniel M
• 通讯作者: Merfeld, Daniel M

Adaptation of vestibular tone studied with electrical stimulation of semicircular canal afferents.

通过半规管传入电刺激研究前庭音调的适应。

• 发表时间: 2013-06
• 作者: Lewis, Richard F;Nicoucar, Keyvan;Gong, Wangsong;Haburcakova, Csilla;Merfeld, Daniel M
• 通讯作者: Merfeld, Daniel M

Spatial and temporal properties of eye movements produced by electrical stimulation of semicircular canal afferents.

由半规管传入电刺激产生的眼球运动的空间和时间特性。

• 发表时间: 2012-09
• 影响因子: 2.5
• 作者: Lewis, Richard F;Haburcakova, Csilla;Gong, Wangsong;Karmali, Faisal;Merfeld, Daniel M
• 通讯作者: Merfeld, Daniel M