NEURAL CORRELATES OF ATTENTIONAL CONTROL OF CONFLICT PROCESSING

冲突处理的注意力控制的神经关联

• 批准号: 7601908
• 负责人: TILMAN SCHULTE
• 金额: $ 0.58万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601908
• 关键词: Adult; Attention; Clinical Research; Color; Computer Retrieval of Information on Scientific Projects Database; Conflict (Psychology); Cues; Disruption; Foundations; Functional Magnetic Resonance Imaging; Funding; Funding Agency; Grant; Hand; Ink; Institution; Left; National Institute on Alcohol Abuse and Alcoholism; Neuropsychology; Parietal; Parietal Lobe; Process; Psychiatry; Psychopharmacology; Publications; Research; Research Personnel; Resources; Running; Sampling; Signal Transduction; Source; Stimulus; System; United States National Institutes of Health; Work; Writing; base; color processing; directed attention; neural circuit; novel; relating to nervous system; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: To identify the neural circuits of conflict processing and attentional allocation with fMRI, we devised a Stroop Match-to-Sample task requiring a decision based on a color cue that directs attention to a specific color and primes the color processing of the stimulus. Healthy right-handed adult volunteers underwent fMRI while performing the Stroop Match-to-Sample task. Subjects matched the color of a cue stimulus in the center of the screen to the color of a Stroop target stimulus. The color cue either matched or did not match the color of the Stroop target, which was either congruent (word blue written in blue ink) or incongruent (word blue written in red ink). Two runs were presented with 18 blocks per run (TR = 2.2 sec). Stroop conflict processing with pretrial color cueing (Match) was associated with BOLD signal increases in a fronto-parietal attention network involving the left ACC, STG, d- PCC and the right parietal cortex. The Match contrast (nonmatch vs. match cue-target color) was mainly associated with d-PCC activation. Conclusion: This paradigm provides a novel differentiation of frontal-parietal attention systems and lays a foundation for clinical research on identifying sources of disruption of neural systems of attention. Funding Sources " This work was supported by NIAAA grants: AA10723, AA05965 Relevant publications " Pfefferbaum A, Adalsteinsson E, Sullivan EV (2006). Biol Psychiatry, 59:364-372. " Schulte T, M¿ller-Oehring EM, Rosenbloom MJ, Pfefferbaum A, Sullivan EV (2005). Biol Psychiatry, 57:67-75. " Schulte, T, M¿ller-Oehring, EM, Salo, R, Pfefferbaum, A, Sullivan, EV (2006). Neuropsychology, 20:727-736. " Sullivan EV, Pfefferbaum (2005). Psychopharmacology, 180:583-94.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以出现在其他 CRISP 条目中 列出的机构是。 对于中心来说，它不一定是研究者的机构。 介绍： 为了通过功能磁共振成像识别冲突处理和注意力的神经回路，我们设计了一个斯特鲁普匹配样本任务，需要基于颜色提示进行决策分配，将注意力引导到特定颜色并启动刺激的颜色处理。 健康的右手成年志愿者在执行斯特鲁普匹配样本任务时进行了功能磁共振成像，受试者将屏幕中心的提示刺激的颜色与斯特鲁普目标刺激的颜色相匹配。与 Stroop 目标的颜色相匹配，该颜色要么一致（用蓝色墨水写的蓝色字），要么不一致（用红色墨水写的蓝色字）。两次运行每次运行 18 个块（TR = 2.2）。试前颜色提示（匹配）的斯特鲁普冲突处理与涉及左侧 ACC、STG、d-PCC 和右侧顶叶皮层的额顶叶注意力网络中的 BOLD 信号增加相关（不匹配与匹配）。提示目标颜色）主要与 d-PCC 激活相关。 结论： 这种范式提供了额叶-顶叶注意力系统的新颖区分，并为识别注意力神经系统破坏来源的临床研究奠定了基础。 资金来源 " 这项工作得到了 NIAAA 拨款的支持：AA10723、AA05965 相关出版物 “ Pfefferbaum A、Adalsteinsson E、Sullivan EV (2006)。Biol Psychiatry，59：364-372。 “ Schulte T、M¿ller-Oehring EM、Rosenbloom MJ、Pfefferbaum A、Sullivan EV (2005)。《生物精神病学》，57:67-75。 “ Schulte, T、M¿ller-Oehring, EM、Salo, R、Pfefferbaum, A、Sullivan, EV (2006)。神经心理学，20：727-736。 “ Sullivan EV，Pfefferbaum (2005)。精神药理学，180：583-94。