Spatial exploration and navigation in the primate hippocampus

灵长类海马体的空间探索和导航

• 批准号: 10732455
• 负责人: CORY T MILLER
• 金额: $ 64.42万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10732455
• 关键词: Spatial; exploration; navigation; primate; hippocampus

Project Summary. Human and nonhuman primates are highly visual animals that are predominantly active during the daylight hours. Yet our understanding of the neural mechanisms supporting spatial navigation is largely based on studies of nocturnal, burrowing rodents with poor vision. Indeed, studies of human and nonhuman primates have already demonstrated that spatial positions can be encoded in the hippocampus exclusively by visual inspection of a scene (i.e. spatial-view cells). At the same time, primate hippocampus also comprises populations of neurons that encode self-position in a scene during locomotion (i.e. place cells). Ultimately, primate representations of space must integrate these parallel threads of spatial information, but precisely how this occurs within the primate hippocampus is entirely unknown. Here we propose to address this fundamental question by leveraging several conceptual, technical and computational innovations to examine the neural basis of spatial representations in the hippocampus of marmoset monkeys. Aim 1 complements our previous work demonstrating canonical place cells in marmoset hippocampus during free-navigation to characterize whether neurons in this neural structure can also encode space through visual exploration of a scene. Aim 2 seeks to systematically characterize behavioral strategies in marmosets when searching for food in naturalistic 3-dimensional `forest' environments. Specifically, we will test how visual exploration and physical navigation of the landscape complement each other in marmoset spatial behavior. Experiments in Aim 3 build on these results to record the activity of hippocampal neurons of freely-moving marmosets in the same 3D naturalistic environments. By integrating head-mounted, wireless eye-tracking technology and video tracking of the animals position in space, we will explicate the role of different primate hippocampal subfields for exploration and navigation.

项目摘要。 人类和非人类灵长类动物是高度视觉动物，在白天几个小时内主要是活跃的动物。 然而，我们对支持空间导航的神经机制的理解主要基于对 夜间，挖洞的啮齿动物，视力差。确实，对人类和非人类灵长类动物的研究已经 证明空间位置可以通过视觉检查在海马中进行编码 场景（即空间视图单元格）。同时，灵长类动物海马也包括神经元的种群 该在运动期间（即位置单元格）中编码自我位置。最终，灵长类动物表示 空间必须集成这些平行信息的这些平行线，但正是灵长类 海马完全未知。在这里，我们建议通过利用几个来解决这个基本问题 概念，技术和计算创新，以检查空间表示的神经基础 猴子猴的海马。 AIM 1补充了我们以前展示规范场所的工作 自由游动期间，果果会海马中的细胞表征该神经结构中的神经元是否存在 还可以通过视觉探索场景来编码空间。 AIM 2试图系统地表征 在自然主义三维“森林”环境中寻找食物时，果果会的行为策略。 具体来说，我们将测试景观的视觉探索和物理导航如何相互补充 在摩尔果空间行为中。 AIM 3中的实验基于这些结果，以记录海马的活性 在同一3D自然主义环境中自由移动的摩尔果的神经元。通过整合头部安装， 无线眼球跟踪技术和动物位置在太空中的位置的视频跟踪，我们将阐明角色 用于勘探和导航的不同灵长类海马子场的不同。