Increasing Recruitment of underrepresented cancer survivors with awareness enhancing interventions (RUN AWEI)

通过提高认识的干预措施增加对代表性不足的癌症幸存者的招募（RUN AWEI）

• 批准号: 10374797
• 负责人: MICHELLE Y MARTIN
• 金额: $ 34.02万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10374797
• 关键词: Address; Adopted; African American; African American population; Alabama; Awareness; Cancer Burden; Cancer Patient; Cancer Survivor; Cancer Survivorship; Clinical Trials; Colorectal Cancer; Control Groups; Decision Making; Dimensions; Education; Enrollment; Ensure; Geographic state; Incidence; Intervention; Knowledge; Lead; Malignant Neoplasms; Malignant neoplasm of prostate; Methods; Minority; Minority Groups; Minority Health Research; Mississippi; Modeling; North Carolina; Observational Study; Outcome; Pamphlets; Participant; Population; Population Study; Principal Investigator; Process; Race; Randomized; Randomized Clinical Trials; Research; Research Design; Research Personnel; Science; Survivors; Target Populations; Tennessee; Testing; Time; Voice; Vulnerable Populations; anticancer research; cancer health disparity; cost; cost effective; design; effectiveness testing; ethnic minority; evidence base; health outcome disparity; improved; innovation; lifestyle intervention; malignant breast neoplasm; men; mortality; novel; population based; racial disparity; racial minority; recruit; research study; trial design

Critical to eliminating cancer health disparities is the ability to engage racial and ethnic minorities in research. Inadequate representation of African Americans (AAs) in research severely limits the opportunity to understand underlying causes of disparate health outcomes between AAs and other race groups and the opportunity to advance knowledge on how to reduce the cancer burden in this vulnerable population. Finding ways to increase recruitment of AA cancer survivors in research is urgent. The question is how. We propose that one mechanism is to increase awareness about research in AA potential participants, a solution supported both by our previous observational study (IMPaCT) in AA cancer survivors, and research by others, in which survivors indicated that having information about clinical trials was important in their decision-making regarding trial participation. However, evidence-based methods to increase awareness in AAs remain largely absent. Unknown is what type of strategy, information, and perspective, is needed. We will test awareness- enhancing interventions (AWEI) that vary in these dimensions among AA cancer survivors for whom disparities in cancer incidence and mortality are widely documented and concerning. We propose a highly innovative and efficient factorial trial design embedded into the recruitment effort for AMPLIFI (P01 CA22997). AMPLIFI will recruit 652 cancer survivors to be randomized to lifestyle interventions. Participants will be from four southeastern states with a high burden of cancer in AAs. During the AMPLIFI recruitment process, 2,000 AA cancer survivors will be randomized to one of 8 AWEI conditions that vary by type of strategy, type of information, and perspective, or to the AMPLIFI basic recruitment strategy (No AWEI). Aims are: 1: Determine the impact of AWEIs on recruitment of AA cancer survivors. We hypothesize that AWEIs will have a significantly higher recruitment yield than the basic AMPLIFI recruitment strategy (H1). In line with IMPaCT, we expect AWEI to have a significant impact doubling the recruitment yield; 2: Identify the AWEI key features that increase recruitment of AA cancer survivors. We will test whether AWEI-navigation vs. AWEI- brochure (type of strategy, H2), study-specific vs general research messages (type of information, H3), and, survivor “voice” vs. not (type of perspective, H4) will result in higher recruitment yield; and 3: Determine the optimal AWEI combination in terms of recruitment yield and cost. We hypothesize that AWEI combination of navigation with study-specific messages and the survivor “voice” will be the most efficacious and may be most cost-effective compared to the other combinations. In summary, building on an important trial that will oversample minorities in underserved US states, our expert team will adopt this innovative and rigorous study design to advance the science of recruitment and have a high impact on representation of AAs in research.

消除癌症健康分布至关重要的是使种族和少数民族参与研究的能力。 非洲裔美国人（AAS）在研究中的代表性不足，严重限制了机会 了解AAS和其他种族组之间的不同健康成果的根本原因以及 有机会促进有关如何减少这种脆弱人群中癌症的知识的机会。发现 迫切需要增加研究中AA癌症存活的方法。问题是如何。我们 建议一种机制是提高对AA潜在参与者研究的认识，这是一种解决方案 我们以前在AA癌症存活中的观察性研究（影响）以及其他人的研究都得到了支持， 其中表面表明，拥有有关临床试验的信息对于他们的决策很重要 考虑审判参与。但是，提高AAS意识的基于证据的方法仍然很大程度上 缺席的。未知是需要哪种类型的策略，信息和观点。我们将测试意识 - 增强干预措施（AWEI）在AA癌症生存中的这些方面有所不同 癌症发病率和死亡率的差异已被广泛记录和有关。我们提出了一个高度的 创新和高效的阶乘试验设计嵌入了Amplifi的招聘工作中（P01 CA22997）。 Amplifi将招募652个癌症存活，以随机分配到生活方式干预措施中。参与者将来自 AAS中有四个东南州，癌症燃烧高。在Amplifi招聘过程中，2,000 AA癌症存活将随机分为8种AWEI条件之一，这些条件因策略类型而异，类型 信息和观点，或者对Amplifi基本招聘策略（无awei）。目的是：1：确定 AWEI对招募AA癌症存活的影响。我们假设Aweis将有一个 招聘收益率明显高于基本的放大招聘策略（H1）。与影响一致，我们 预计AWEI会产生重大影响，使招聘收益率增加一倍； 2：确定AWEI关键功能 这增加了AA癌症存活的募集。我们将测试Awei-Navigation是否与Awei- 小册子（策略类型，H2），特定研究与一般研究信息（信息类型，H3）以及 幸存者“语音”与Not（视角类型，H4）将导致招募收益率更高；和3：确定 最佳的AWEI组合在招聘收益率和成本方面。我们假设Awei 导航与特定研究的信息和幸存者“声音”的结合将是最有效的 与其他组合相比，可能是最具成本效益的。总而言之，在一个重要的试验中进行建设 这将在美国服务不足的州中过度采样少数群体，我们的专家团队将采用这种创新性和 严格的研究设计，以提高招聘科学，并对AAS的代表产生很大影响 在研究中。