Increasing Recruitment of underrepresented cancer survivors with awareness enhancing interventions (RUN AWEI)

通过提高认识的干预措施增加对代表性不足的癌症幸存者的招募（RUN AWEI）

• 批准号: 10374797
• 负责人: MICHELLE Y MARTIN
• 金额: $ 34.02万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10374797
• 关键词: Address; Adopted; African American; African American population; Alabama; Awareness; Cancer Burden; Cancer Patient; Cancer Survivor; Cancer Survivorship; Clinical Trials; Colorectal Cancer; Control Groups; Decision Making; Dimensions; Education; Enrollment; Ensure; Geographic state; Incidence; Intervention; Knowledge; Lead; Malignant Neoplasms; Malignant neoplasm of prostate; Methods; Minority; Minority Groups; Minority Health Research; Mississippi; Modeling; North Carolina; Observational Study; Outcome; Pamphlets; Participant; Population; Population Study; Principal Investigator; Process; Race; Randomized; Randomized Clinical Trials; Research; Research Design; Research Personnel; Science; Survivors; Target Populations; Tennessee; Testing; Time; Voice; Vulnerable Populations; anticancer research; cancer health disparity; cost; cost effective; design; effectiveness testing; ethnic minority; evidence base; health outcome disparity; improved; innovation; lifestyle intervention; malignant breast neoplasm; men; mortality; novel; population based; racial disparity; racial minority; recruit; research study; trial design

Critical to eliminating cancer health disparities is the ability to engage racial and ethnic minorities in research. Inadequate representation of African Americans (AAs) in research severely limits the opportunity to understand underlying causes of disparate health outcomes between AAs and other race groups and the opportunity to advance knowledge on how to reduce the cancer burden in this vulnerable population. Finding ways to increase recruitment of AA cancer survivors in research is urgent. The question is how. We propose that one mechanism is to increase awareness about research in AA potential participants, a solution supported both by our previous observational study (IMPaCT) in AA cancer survivors, and research by others, in which survivors indicated that having information about clinical trials was important in their decision-making regarding trial participation. However, evidence-based methods to increase awareness in AAs remain largely absent. Unknown is what type of strategy, information, and perspective, is needed. We will test awareness- enhancing interventions (AWEI) that vary in these dimensions among AA cancer survivors for whom disparities in cancer incidence and mortality are widely documented and concerning. We propose a highly innovative and efficient factorial trial design embedded into the recruitment effort for AMPLIFI (P01 CA22997). AMPLIFI will recruit 652 cancer survivors to be randomized to lifestyle interventions. Participants will be from four southeastern states with a high burden of cancer in AAs. During the AMPLIFI recruitment process, 2,000 AA cancer survivors will be randomized to one of 8 AWEI conditions that vary by type of strategy, type of information, and perspective, or to the AMPLIFI basic recruitment strategy (No AWEI). Aims are: 1: Determine the impact of AWEIs on recruitment of AA cancer survivors. We hypothesize that AWEIs will have a significantly higher recruitment yield than the basic AMPLIFI recruitment strategy (H1). In line with IMPaCT, we expect AWEI to have a significant impact doubling the recruitment yield; 2: Identify the AWEI key features that increase recruitment of AA cancer survivors. We will test whether AWEI-navigation vs. AWEI- brochure (type of strategy, H2), study-specific vs general research messages (type of information, H3), and, survivor “voice” vs. not (type of perspective, H4) will result in higher recruitment yield; and 3: Determine the optimal AWEI combination in terms of recruitment yield and cost. We hypothesize that AWEI combination of navigation with study-specific messages and the survivor “voice” will be the most efficacious and may be most cost-effective compared to the other combinations. In summary, building on an important trial that will oversample minorities in underserved US states, our expert team will adopt this innovative and rigorous study design to advance the science of recruitment and have a high impact on representation of AAs in research.

消除癌症健康差异的关键是让少数种族和族裔参与研究的能力。 非裔美国人 (AA) 在研究中的代表性不足严重限制了研究的机会 AA 和其他种族群体之间健康结果差异的根本原因以及 提高有关如何减轻这一弱势群体癌症负担的知识的机会。 如何增加 AA 癌症幸存者的研究规模已迫在眉睫。 一种机制是提高 AA 潜在参与者对研究提案的认识，这是一种解决方案 我们之前针对 AA 癌症幸存者进行的观察性研究 (IMPACT) 以及其他人的研究都支持了这一点， 其中幸存者表示，了解临床试验的信息对于他们的决策非常重要 然而，提高 AA 意识的基于证据的方法仍然主要存在。 未知的是需要什么类型的策略、信息和观点，我们将测试意识。 AA 癌症幸存者的增强干预措施 (AWEI) 在这些方面有所不同 癌症发病率和死亡率的差异已被广泛记录并令人担忧。 AMPLIFI (P01 CA22997) 的招募工作中融入了创新且高效的因子试验设计。 AMPLIFI 将招募 652 名癌症幸存者，随机接受生活方式干预。 AA 中癌症负担较高的四个东南部州 在 AMPLIFI 招募过程中，招募了 2,000 名患者。 AA 癌症幸存者将被随机分配到 8 种 AWEI 病症中的一种，这些病症因策略类型、治疗类型而异。 信息、观点或 AMPLIFI 基本招聘策略（无 AWEI） 目标是： 1：确定。 AWEIs 对招募 AA 癌症幸存者的影响 我们认为 AWEIs 将有一个 招募率明显高于基本 AMPLIFI 招募策略 (H1) 与 IMPaCT 一致，我们。 期望 AWEI 产生重大影响，使招聘率翻倍 2：确定 AWEI 的关键特征； 我们将测试 AWEI-navigation 与 AWEI-navigation 是否会增加招募 AA 癌症幸存者。 小册子（策略类型，H2），特定研究与一般研究信息（信息类型，H3），以及， 幸存者“声音”与非声音（视角类型，H4）将导致更高的招募率；3：确定 在招聘率和成本方面的最佳 AWEI 组合 我们勇敢地说 AWEI。 导航与研究特定信息和幸存者“声音”的结合将是最有效的 总之，与其他组合相比，它可能是最具成本效益的。 这将对美国服务不足的州的少数族裔进行过度抽样，我们的专家团队将采用这种创新和 严格的研究设计，以推进招聘科学并对 AA 的代表性产生重大影响 在研究中。