Dynamic OCE with acoustic micro-tapping for in vivo monitoring of skin graft surgeries

具有声学微敲击功能的动态 OCE，用于皮肤移植手术的体内监测

• 批准号: 10374914
• 负责人: IVAN PELIVANOV
• 金额: $ 55.92万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10374914
• 关键词: 3-Dimensional; 4D Imaging; Acoustics; Age; Air; Algorithms; Angiography; Anisotropy; Area; Back; Benchmarking; Biomechanics; Body mass index; Breast; Cicatrix; Clinic; Clinical; Clinical Protocols; Collagen; Cornea; Cosmetics; Coupled; Data; Dermatology; Donor person; Elasticity; Ensure; Environment; Esthetics; Face; Feedback; Forearm; Future; Gender; Goals; Human; Image; Imaging Device; Inflammation; Magnetic Resonance Imaging; Maps; Measurement; Measures; Mechanics; Medical; Methods; Modeling; Modulus; Monitor; Neck; Operative Surgical Procedures; Optics; Organ Transplantation; Outcome; Patients; Persons; Phase; Plastic Surgical Procedures; Population; Postoperative Procedures; Procedures; Process; Property; Protocols documentation; Radiation; Radiology Specialty; Reconstructive Surgical Procedures; Recovery; Resolution; Robot; Robotics; Sampling; Site; Skin; Skin graft; Structure; Subcutaneous Tissue; Surgical Oncology; System; Techniques; Testing; Therapeutic; Thick; Time; Tissue Donors; Tissue Grafts; Tissues; Transplantation; base; biomechanical model; clinical application; clinical efficacy; clinical translation; elastography; experimental study; foot; graft healing; healing; healthy volunteer; human subject; in vivo; in vivo imaging system; in vivo monitoring; innovation; instrument; reconstruction; tool; ultrasound

Abstract The goal of this project is a develop a non-contact, non-invasive clinical tool to characterize, image and monitor skin grafting procedures using quantitative, volumetric, sub-mm resolved maps of Young's modulus based on Optical Coherence Elastography (OCE). Factors related to or directly defined by skin's elastic properties (such as contractions and shearing forces) are among the most common complications of full thickness skin graft (FTSG) procedures. In addition, the recipient site functions best when its elastic properties are matched by transplanted donor tissue. With tens of millions of aesthetic procedures performed every year in the USA alone, surgical cosmesis is clearly critical, especially when procedures are performed on the face, neck or breast. Currently there are no clinical tools, or even methods, that can quantitatively map skin's Young's modulus and anisotropy in vivo. We propose to map these parameters in skin using a non-contact, fully non-invasive method, with sub-mm spatial resolution and nearly in real time. We hypothesize that quantifying skin elasticity in vivo will enable significant innovation within all areas of plastic surgery, burn surgery, oncologic surgery, and dermatology that modify a patient's tissue quality and elastic properties through medical, radiologic, or surgical intervention. To achieve our objective, we propose a new non-contact OCE method. Our approach is based on: (i) acoustic micro-tapping (AµT) using ultrasound propagating in air to launch mechanical waves in soft media with the highest efficiency and best resolution among all non-contact wave-excitation methods, (ii) state-of-the-art real- time 4-D PhS-OCT imaging to track wave propagation, and (iii) reconstruction of volumetric maps of Young's modulus and anisotropy using imaged wavefields in skin analyzed with a transversally isotropic model. SA1 will focus on refining previously developed analytic and numerical models of mechanical wave propagation in skin considering its layered anisotropic structure, and developing algorithms to reconstruct skin's moduli. Then, SA2 will develop a robotized AµT-OCE imaging system for in vivo skin measurements in a clinical environment. We will perform routine measurements of skin elastic moduli in vivo on healthy volunteers to understand normal variability in skin elastic properties in a representative population of normal human subjects to help define the level of expected improvements possible in matching skin elastic properties in FTSG procedures. SA3 will focus on in vivo monitoring changes in grafted skin elastic properties during grafting procedures in the clinic, including pre-operative mapping of skin's elastic properties in donor and recipient sites and mapping longitudinal changes in fundamental structural and elastic parameters of FTSGs and surrounding tissue over the reconstruction process. If successful, this project can be the starting point for multiple continuation projects testing whether new methods and clinical protocols can be developed using information from OCE to help select the best donor tissue for grafting and guide post-surgery procedures.

抽象的 该项目的目标是开发一种非接触式、非侵入性临床工具来表征、成像和 使用定量、体积、亚毫米分辨率的杨氏图监测植皮手术 基于光学相干弹性成像（OCE）的模量。 与皮肤弹性特性相关或直接由其定义的因素（例如收缩力和剪切力）是 这是全层皮肤移植 (FTSG) 手术最常见的并发症之一。 当其弹性特性与移植的供体组织相匹配时，该部位的功能最佳。 仅在美国每年进行的美容手术中，手术美容显然至关重要，尤其是 目前还没有临床工具，甚至没有在面部、颈部或乳房上进行手术的情况。 方法，可以定量绘制体内皮肤的杨氏模量和各向异性。 使用非接触式、完全非侵入性方法，具有亚毫米空间分辨率和 我们认为，量化体内皮肤弹性将能够实现重大创新。 整形外科、烧伤外科、肿瘤外科和皮肤科中修改患者组织的所有领域 通过医疗、放射学或外科手术干预获得质量和弹性。 为了实现我们的目标，我们提出了一种新的非接触式 OCE 方法。我们的方法基于：(i) 声学。 微攻（AμT）利用空气中传播的超声波在软介质中发射机械波 所有非接触式波激励方法中最高的效率和最佳分辨率，（ii）最先进的实时 时间 4-D PhS-OCT 成像来跟踪波传播，以及 (iii) 重建杨氏体积图 使用横向各向同性模型分析皮肤中的成像波场来分析模量和各向异性。 SA1将专注于完善先前开发的机械波分析和数值模型 考虑其分层各向异性结构在皮肤中的传播，并开发重建算法 然后，SA2 将开发一种机器人化 AμT-OCE 成像系统，用于体内皮肤测量。 我们将对健康人进行体内皮肤弹性模量的常规测量。 志愿者了解代表性正常人群皮肤弹性特性的正常变异性 人类受试者帮助确定匹配皮肤弹性特性方面可能的预期改进水平 在 FTSG 程序中，SA3 将重点关注移植皮肤弹性特性的体内变化。 临床移植程序，包括术前绘制供体和移植者皮肤的弹性特性 受体位点并绘制 FTSG 基本结构和弹性参数的纵向变化 如果成功，该项目可以成为重建过程的起点。 多个延续项目测试是否可以使用以下方法开发新方法和临床方案 来自 OCE 的信息可帮助选择最佳的移植供体组织并指导术后程序。