1/2 Assessing the Cumulative Impact of Early Life Substance and Environment Exposure on Child Neurodevelopment and Health

1/2 评估生命早期物质和环境暴露对儿童神经发育和健康的累积影响

基本信息

批准号：
10381103
负责人：
Viren Andrew D'Sa
金额：
$ 1.18万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2022-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10381103
关键词：
Achievement Address Affect Age Analgesics Area Attention Attitude Behavioral Birth Brain COVID-19 COVID-19 pandemic California Child Child Development Childhood Cognitive Communication Communities Complex Conceptions County Data Data Collection Development Economics Electrocardiogram Electroencephalography Environment Environmental Exposure Environmental Risk Factor Epidemiologic Methods Family Fentanyl Foundations Frequencies Genetic Genotype Growth Health Health Care Research Health Policy Health Services Heart Heroin Home Human Characteristics Individual Infant Lead Learning Life Light Low income Magnetic Resonance Imaging Masks Measurement Measures Mediating Memory Methods Mother-Child Relations National Institute of Drug Abuse Nature Neighborhoods Neonatal Abstinence Syndrome Neurocognitive Neurosciences New England Newborn Infant Nutritional Opioid Outcome Parent-Child Relations Participant Pathway interactions Pattern Physical environment Physiology Play Population Process Protocols documentation Public Health Recording of previous events Research Resources Rhode Island Sampling Sampling Studies Science Selection Bias Services Shapes Site Sleep Socioeconomic Factors Structure Substance Withdrawal Syndrome System Time Tissues Trust base behavioral phenotyping brain shape caregiving cognitive neuroscience community engagement data harmonization demographics distrust early childhood economic disparity ethnic minority population experience fetal fetal substance exposure health equity health inequalities high dimensionality in utero infancy innovation multimodality myelination neurobehavior neurodevelopment neuroimaging nutrition opioid epidemic peer phenotypic data postnatal pregnant prenatal prenatal exposure psychosocial racial disparity racial equality racial minority racism relating to nervous system repository skills social social capital social equality socioeconomics study population substance use synaptogenesis treatment services visual tracking

项目摘要

PROJECT SUMMARY / DESCRIPTION What are the neurodevelopmental sequelae of in utero opiate and other substance exposure? The succinct nature of this question masks the complex and multifaceted nature of human neurodevelopment, and the diversity of environmental influences that can mediate or moderate the initial direct effects substances may have on the developing brain. From conception to age 10, our brain undergoes remarkable structural and functional growth. Neurodevelopmental processes that include myelination and synaptogenesis are at their peak, responding to integrative cascades of genetic and environmental interactions as they mature neural systems and provide the foundation for emerging cognitive and behavioral skills. The patterns of this early development reflects adaptation to the child's direct and contextual environments and, thus, the potential impact of in utero substance exposures must be considered within the broader family, psychosocial, economic, and physical environment. Over the past year, these environments have witnessed unprecedented upheaval as a result of the COVID-19 pandemic, impacting children, families, and pregnant individuals with disproportionate impact on lower-income, and racial and ethnic minority families - the very families already shaken by the ongoing opioid crisis. Our proposal aims to understand the neurodevelopmental impact of these converging experiences. We will collect deep multi-level and repeat neuroimaging and behavioral phenotype data, alongside rich contextual measures of environmental exposures centered on the child's lived experience, including social equity and socioeconomic factors. Building from a central hypothesis that brain development is an integrative process that is shaped by prenatal insults (opiate and other substance exposures) and ongoing postnatal influences against a backdrop of social,economic, and health inequalities we will: 1. Characterize the variability of `neurotypical' development, recognizing that multiple pathways reflecting individual adaption may lead to the same outcomes; 2. Examine how in utero substance exposures alter these patterns and pathways; and 3. Take a holistic and integrated approach to understanding how the diversity of a child's environment shapes and modifies brain patterns and outcomes. Achievement of these aims requires a careful and purposefully planned study with unbiased measures, community partners, and representative socioeconomic and demographic populations - communities with well-founded distrust of research and public health workers. At the heart of our proposal is the principle of access. We will reduce traditional barriers to participation using innovative data collection methods and mobile labs to bring the research to under-represented and marginalized communities; and build trusted connections with our participating families through our established community advisory boards and peer navigator networks. Our approach, therefore, aims to clarify the impact of substance exposure on child development whilst shifting the field of developmental neuroscience and substance use to a more equitable standard of research, with generalizable findings that can guide non-punitive public health policies.

项目概要/描述子宫内阿片类药物和其他物质暴露会造成哪些神经发育后遗症？简洁的这个问题的本质掩盖了人类神经发育的复杂性和多方面性，可以调节或缓和物质可能产生的最初直接影响的环境影响的多样性关于发育中的大脑。从受孕到 10 岁，我们的大脑经历了显着的结构和功能变化生长。包括髓鞘形成和突触发生在内的神经发育过程正处于顶峰，当神经系统成熟时，对遗传和环境相互作用的综合级联反应做出反应并为新兴的认知和行为技能提供基础。早期发展的模式反映了对儿童直接和背景环境的适应，从而反映了子宫内的潜在影响必须在更广泛的家庭、社会心理、经济和身体方面考虑物质暴露环境。在过去的一年里，这些环境经历了前所未有的剧变。 COVID-19 大流行对儿童、家庭和孕妇产生了影响，其中对低收入、种族和族裔家庭——正是这些家庭已经受到持续的阿片类药物的影响危机。我们的建议旨在了解这些融合经历对神经发育的影响。我们将收集深入的多层次和重复的神经影像和行为表型数据，以及丰富的上下文以儿童的生活经历为中心的环境暴露衡量标准，包括社会公平和社会经济因素。基于大脑发育是一个综合过程的中心假设是由产前侮辱（鸦片和其他物质暴露）和持续的产后影响形成的在社会、经济和健康不平等的背景下，我们将： 1. 描述“神经典型”的变异性发展，认识到反映个体适应的多种途径可能会导致相同的结果； 2. 检查子宫内物质暴露如何改变这些模式和途径； 3. 采取整体和了解儿童环境的多样性如何塑造和改变大脑的综合方法模式和结果。实现这些目标需要进行仔细和有目的地计划的研究公正的措施、社区合作伙伴以及具有代表性的社会经济和人口群体 - 对研究和公共卫生工作者有充分理由不信任的社区。我们建议的核心是准入原则。我们将使用创新的数据收集方法减少传统的参与障碍和移动实验室，将研究成果带到代表性不足和边缘化的社区；并建立值得信赖的通过我们建立的社区咨询委员会和同侪与我们的参与家庭建立联系导航器网络。因此，我们的方法旨在澄清物质暴露对儿童的影响发展，同时将发展神经科学和物质使用领域转向更公平的领域研究标准，具有可指导非惩罚性公共卫生政策的普遍发现。