Phenomenon of Ultra-Early Erythrolysis in Intracranial Hemorrhage in Humans on MRI

MRI 人类颅内出血超早期红细胞溶解现象

• 批准号: 9789960
• 负责人: Neeraj Chaudhary
• 金额: $ 19.5万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9789960
• 关键词: Algorithms; Animal Model; Animals; Area; Attention; Autologous; Blood; Brain; Brain Edema; Brain Injuries; Brain hemorrhage; Cell Death; Cerebral hemisphere hemorrhage; Clinical Data; Coagulation Process; Cytolysis; Data; Deposition; Edema; Erythrocytes; Event; Ferritin; Hematoma; Hemolysis; Hemorrhage; Histology; Hour; Human; Injury; Intracranial Hemorrhages; Iron; Iron-Binding Proteins; Lead; Magnetic Resonance Imaging; Maps; Measures; Mediating; Modeling; Natural History; Neurologic Deficit; Neuronal Injury; Neurons; Outcome; Pathway interactions; Patients; Peripheral; Phase; Population; Production; Proteins; Publishing; Rattus; Resolution; Role; Secondary to; Series; Serum; Stroke; Study models; Supportive care; System; Thrombin; Time; Tissues; Toxic effect; base; brain cell; brain tissue; data modeling; experimental study; human subject; improved outcome; macrophage; neurotoxicity; novel; response

Abstract Intracerebral Hemorrhage is a subtype of hemorrhagic stroke that has devastating consequences when it occurs in humans. Broadly there are two mechanisms of neuronal damage that occurs in the event of an ICH. The early brain injury is secondary to the hematoma itself and early erythrolysis within 24 hours of the injury. Delayed brain injury is mediated by various pathways related to the scavenging of the hematoma by the macrophage system. There is reasonable animal model data that validates pathomechanisms of delayed neurotoxicity following an ICH. Ultra-early erythrolysis is a novel phenomenon that has been observed in a recent animal ICH model study by the authors. In this rat model there is good correlation of early erythrolysis with hypo or isointensity on T2* sequences within the hematoma within first 24 hours after an ICH and increased tissue iron levels in the perihematomal brain tissue on histology. There is no such correlative phenomenon that has been documented in the human population. The proposed study will attempt to confirm or refute the presence of the phenomenon of ultra-early erythrolysis and mediated neuronal injury due to increased iron levels in the periphery of the hematoma based on MRI. Various MRI parameters like volume of T2* iso/non-hypointensity within the hematoma, R2* value in the periphery of the hematoma and volume of edema on FLAIR sequence will be measured on day 1, day14 and day 30 to evaluate the presence of the phenomenon of ultra-early erythrolysis in ICH in human subjects, not only in the first 24 hrs but also up to 30 days following the hematoma.

抽象的 脑内出血是出血性中风的亚型，发生时具有毁灭性后果 在人类中。从广义上讲，在ICH发生的情况下，存在两种神经元损伤的机制。早 脑损伤是血肿本身的继发性，在损伤后24小时内早期粒细胞解析。大脑延迟 损伤是由与巨噬细胞系统清除血肿有关的各种途径。 有合理的动物模型数据验证了延迟神经毒性的病理机理 ich。超前的红斑化是一种新的现象，在最近的动物ICH模型研究中已经观察到了 由作者。在这种大鼠模型中，早期粒细胞解析与T2*上的低或同性强度有良好的相关性 ICH之后的头24小时内血肿内的序列，并增加了组织铁的水平 组织学上的围围围脑膜组织。没有记录的这种相关现象 在人口中。拟议的研究将试图确认或反驳现象的存在 由于铁水平增加而导致的超前红血病和介导的神经元损伤 基于MRI的血肿。各种MRI参数，例如T2* ISO/非高压量的体积 血肿，r2*在血肿的周围和天赋序列的水肿体积中的值为 在第1天，第14天和第30天进行测量，以评估超前红细胞化现象的存在 ICH在人类受试者中，不仅在最初的24小时，而且在血肿后长达30天。