Understanding and Addressing Cancer Health Disparities in Louisiana

了解并解决路易斯安那州的癌症健康差异

• 批准号: 9630120
• 负责人: Lucio Miele
• 金额: $ 97.61万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-19 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9630120
• 关键词: Address; Affect; African American; Area; Biological; Biological Factors; Biology; Breast Cancer Patient; Cancer Biology; Cancer Center; Cancer Center Planning Grant; Cancer Etiology; Characteristics; Chemotherapy-Oncologic Procedure; Clinical; Clinical Trials; Comorbidity; Complex; Data; Diagnosis; Disease; Disease Outcome; Elements; Endometrial; Endometrial Carcinoma; Ensure; Environmental Risk Factor; Epidemiology; Future; Genetic; Genomics; Goals; Grant; Immune; Immunity; Immunologics; Immunology; Immunotherapy; Impairment; In complete remission; Incidence; Inequality; Infiltration; Inflammation; Inflammatory; Institution; Intervention; Investigation; Leadership; Light; Literature; Liver; Louisiana; Malignant Neoplasms; Malignant neoplasm of prostate; Measurable; Medical; Metabolic; Metabolism; Minority; Mutation; Myeloid-derived suppressor cells; Neoadjuvant Therapy; Not Hispanic or Latino; Obesity; Outcome; Pathologic; Patient-Focused Outcomes; Patients; Pharmaceutical Preparations; Politics; Population; Portraits; Prevention; Preventive Intervention; Primary carcinoma of the liver cells; Prognostic Marker; Public Health; Renal Cell Carcinoma; Renal carcinoma; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Role; Socioeconomic Factors; Stress; Survival Rate; T cell response; T-Lymphocyte; Testing; Therapeutic Intervention; Transcript; Treatment Efficacy; Tumor Biology; Tumor Immunity; Underserved Population; Woman; Work; cancer health disparity; cancer therapy; chemotherapy; fatty acid oxidation; genomic signature; gulf coast; health care availability; health disparity; improved; improved outcome; inhibitor/antagonist; insight; malignant breast neoplasm; molecular subtypes; mortality; novel; novel diagnostics; novel strategies; novel therapeutic intervention; novel therapeutics; nutrition; patient population; resistance mechanism; response; social health determinants; socioeconomics; success; tool; triple-negative invasive breast carcinoma; tumor

ABSTRACT: Cancer health disparities represent a major public health crisis in the state of Louisiana and the Gulf Coast. The citizens of this region have to contend with cancer incidence and mortality rates that are among the highest in the nation. In addition, we have a very high incidence of specific malignancies that disproportionately affect minorities and the underserved citizens of the region. Triple negative breast cancer, hepatocellular carcinoma, endometrial cancer, advanced prostate cancer, renal cell carcinoma, among others, are more common and appear to be more aggressive among minorities. Complex socio-economic and political reasons and an increase in co-morbidities, such as obesity, may in part help explain the origin of some of these health disparities. However, increasing evidence from genomics and cancer biology, including our work, has started to shed light on the biological basis for some of these inequities, and suggests specific interventions to help ameliorate the impact of these diseases and improve patient outcomes. We plan to use this P20 planning grant to establish research projects that bring together the best investigators and institutions in Louisiana who are conducting research on the genetics/genomics, immunology, and clinical and public health aspects of cancer with special emphasis on health disparities. Under the leadership of the LSU Stanley S. Scott Cancer Center in New Orleans (LSU-CC-NO) and in partnership with investigators from academic and medical institutions in the state, we have agreed to conduct research under the new Gulf South Center for Research and Solutions in Cancer Health Disparities (Gulf South-CARES-CHD). To ensure a focused and productive effort, this P20 grant we will study the genomic signature and inflammation characteristics of triple negative breast cancer (TNBC), a disease that disproportionately affects young African-American women in Louisiana. We believe that understanding the genomics and inflammatory biology of specific cancers may provide insights into mechanisms of resistance to neoadjuvant chemotherapy and help identify and test potential interventions for improving the therapeutic efficacy of current and future treatments. Besides creating competitive teams of researchers, we will build the necessary intellectual and organizational infrastructure and develop the preliminary data to plan and support research projects that qualify for a SPORE application. Our combined expertise, the unique patient populations available in Louisiana, and the commitment of our institutions will enable us to achieve these goals, which will improve prevention, diagnosis and treatment of cancer in underserved populations, both in Louisiana and globally.

抽象的： 癌症健康差异代表了路易斯安那州和墨西哥湾沿岸的重大公共卫生危机。 该地区的公民必须与癌症发病率和死亡率抗衡 全国最高。此外，我们的特定恶性肿瘤发生率很高 不成比例地影响少数民族和服务不足的公民。三重阴性乳腺癌， 肝细胞癌，子宫内膜癌，晚期前列腺癌，肾细胞癌， 其他，更普遍，在少数民族中似乎更具侵略性。复杂的社会经济 以及政治原因以及肥胖等合并症的增加可能有助于解释 其中一些健康差异。但是，越来越多的证据来自基因组学和癌症生物学，包括 我们的工作已经开始阐明其中一些不平等的生物学基础，并提出了具体的 干预措施有助于改善这些疾病的影响并改善患者的结果。我们计划使用 这项P20计划赠款旨在建立研究项目，以汇集最佳研究人员和 路易斯安那州的机构正在研究遗传学/基因组学，免疫学和临床的研究 以及癌症的公共卫生方面，特别强调健康差异。在 LSU Stanley S. Scott Cancer Center位于新奥尔良（LSU-CC-NO），并与来自的调查员合作 该州的学术和医疗机构，我们同意根据新海湾进行研究 南方研究与解决方案中心癌症健康差异（Gulf South-Cares-CHD）。确保 这项P20赠款是一项集中和富有成效的努力，我们将研究基因组签名和炎症 三重阴性乳腺癌（TNBC）的特征，这种疾病对年轻人的影响不成比例 路易斯安那州的非裔美国妇女。我们认为了解基因组学和炎症 特定癌症的生物学可能会洞悉对新辅助化疗的抗性机制 并有助于识别和测试潜在的干预措施，以提高当前和未来的治疗功效 治疗。除了创建竞争性的研究人员团队外，我们还将建立必要的知识分子和 组织基础架构并制定初步数据，以计划和支持研究项目 有资格获得孢子申请。我们的联合专业知识，独特的患者人群 路易斯安那州以及我们机构的承诺将使我们能够实现这些目标，这将改善 在路易斯安那州和全球范围内，在服务不足的人群中预防，诊断和治疗。