Piloting a naloxone intervention in an emergency response community to reduce opioid overdoses in Philadelphia
在费城的应急响应社区试点纳洛酮干预措施,以减少阿片类药物过量
基本信息
- 批准号:9403417
- 负责人:
- 金额:$ 22.79万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-07-01 至 2020-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
PROJECT SUMMARY/ABSTRACT
The escalating opioid overdose epidemic is one of the most serious public health problems confronting the
U.S. In 2014, a record 47,055 people died from a drug overdose in the U.S., which outnumbered deaths
from motor vehicle crashes by approximately one and a half times. Heroin and misuse of prescription
Death due to drug overdose is a significant and
rising cause of mortality and morbidity in Philadelphia. In 2015, almost 700 drug overdose deaths were
opioids
contributed to a majority of drug overdoses in 2014.
reported in Philadelphia – twice as many as deaths from homicide. In response, health policy, legislation,
and research funding are increasingly converging in support of the distribution of naloxone, an opioid
antagonist, and community-based opioid overdose prevention programs (OPP). The success of OPP is
contingent upon the willingness and effectiveness of bystanders to respond to an overdose event and
administer naloxone. Emergency Response Communities (ERC) are specialized smartphone-based social
networks in which members are approved carriers and/or potential users of a specific medication, such as
naloxone. The ERC approach is ideally suited to support, facilitate, and encourage naloxone administration
in opioid overdose emergencies, but is untested to date. The model combines GPS and IP-location tracking
to identify potential opioid overdose through a smartphone application or app. Towards this end, we are
proposing to utilize an ERC in the development and pilot testing of a
smartphone app-based naxolone
intervention (ERC-NAX) in Philadelphia.
Research is needed to understand the needs and barriers in
communities at high-risk for opioid overdose that will enable effective design, adaption, and implementation
of an ERC-NAX app.
pursue three specific
Guided by preliminary data from study investigators, the proposed pilot project will
aims: 1) Identify barriers and facilitators of acceptance and use of a smartphone-
based ERC naloxone intervention; 2) Pilot test the implementation of ERC-NAX in an ERC consisting of 55
non-medical opioid users and 55 community members; 3) Synthesize knowledge acquired in Aims 1 and 2
to be used in a subsequent R01 study to conduct a large-scale, multi-site implementation trial. This 3-year
study will provide actionable evidence regarding the viability and acceptance of an app-based naloxone
intervention following the ERC model. It will be developed and tested in partnership with two community
partners in Philadelphia with extensive experience in overdose prevention. This proposed intervention is
significant since it leverages the growing success of OPP and will empower communities
at high-risk for
to provide rapid, secure, and effective emergency response in the event of overdose. This
novel intervention, which is designed to augment emergency medical services in the rapid delivery of
opioid overdose
naloxone to overdose victims, may be effective at deescalating the epidemic of opioid overdose fatalities in
Philadelphia and communities elsewhere.
项目摘要/摘要
不断升级的阿片类药物过量流行是面临的最严重的公共卫生问题之一
2014年,美国,有47,055人死于美国的药物过量,该药物过量超过死亡人数
从汽车坠毁大约一半。海洛因和处方的小姐
由于药物过量而导致的死亡是重要的,并且
费城死亡率和发病率的增加。 2015年,近700例药物过量死亡是
阿片类药物
2014年导致大多数药物过量。
在费城报道,凶杀案死亡的两倍。作为回应,卫生政策,立法,
研究资金越来越多地融合以支持阿片类药物纳洛酮的分布
对抗者和基于社区的阿片类药物预防计划(OPP)。 OPP的成功是
取决于旁观者应对过量事件的意愿和有效性
管理纳洛酮。紧急响应社区(ERC)是基于智能手机的专门社交
成员被批准的运营商和/或特定药物的潜在用户的网络,例如
纳洛酮。 ERC方法非常适合支持,促进和鼓励纳洛酮给药
在阿片类药物过量的紧急情况下,但迄今未经测试。该模型结合了GPS和IP-Location Trucking
通过智能手机应用程序或应用识别潜在的阿片类药物过量。为此,我们是
提议在开发和试点测试中利用ERC
基于智能手机应用程序的Naxolone
费城的干预(ERC-NAX)。
需要研究以了解
高风险的阿片类药物过量的社区将实现有效的设计,适应和实施
ERC-NAX应用程序。
追求三个特定的
在研究调查人员的初步数据的指导下,拟议的试点项目将
目的:1)确定接受和使用智能手机的障碍和促进者 -
基于ERC纳洛酮的干预; 2)试点测试由55个ERC中的ERC-NAX实施
非医疗阿片类药物用户和55名社区成员; 3)在目标1和2中获得的知识合成知识
在随后的R01研究中用于进行大规模的多站点实施试验。这三年
研究将提供有关基于应用的纳洛酮的生存能力和接受的可行证据
遵循ERC模型的干预措施。它将与两个社区合作开发和测试
费城的合作伙伴在预防过量方面拥有丰富的经验。拟议的干预是
意义重大,因为它利用了OPP的日益成功,并将赋予社区能力
在高风险
在服药过量的情况下,提供快速,安全和有效的应急响应。这
新颖的干预措施,旨在在快速交付时增加紧急医疗服务
阿片类药物过量
纳洛酮滥用过量,可能有效地加深阿片类药物过量死亡的流行
费城和其他地方的社区。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

暂无数据
数据更新时间:2024-06-01
Stephen E Lankenau的其他基金
UnityPhilly Response App for Overdose Reversal: Assessing Citywide Effectiveness and Sustainability
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