Core F: Canine Cell & Molecular Resources

核心F：犬细胞

• 批准号: 8566007
• 负责人: Patrick Paddison
• 金额: $ 17.48万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-15 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8566007
• 关键词: Breeding; Canis familiaris; Cell Line; Cells; Complementary DNA; DNA; Development; Genes; Genome; Hematology; Hematopoiesis; Human; Knock-out; Libraries; Life; Modeling; Molecular; Outcome; Patients; Reagent; Resources; Stem cell transplant; Tissues; base; design; efficacy testing; graft vs host disease; knock-down; novel therapeutics; preclinical efficacy; preclinical safety; research study; response; small hairpin RNA; vector

Core F is a developing core designed to generate canine specific cell and molecular reagents to enhance the value of the canine model for preclinical safety and efficacy testing of new therapeutics. As a large, relatively long-lived, out bred specie, the dog has many similarities with humans. Specifically in regard to hematopoiesis and stem cell transplantation the dog model has been highly predictive of outcomes in human patients, including the development of graft-versus-host disease and its response to treatment. In addition to celllines, tissue, DNA, and cDNA already available. Core F will generate canine specific shRNA libraries for knock down experiments.

核心F是一种开发的核心，旨在生成犬类特异性细胞和分子试剂 增强犬类模型对新疗法的临床前安全性和功效测试的价值。作为 大型，相对较长的饲养规格，这只狗与人类有许多相似之处。具体而言 对于造血和干细胞移植，狗模型已经高度预测了结果 人类患者，包括发展移植抗宿主疾病及其对治疗的反应。在 补充已经可用的细胞线，组织，DNA和cDNA。核F将产生犬类特异性shRNA 库库库的库。