Adaptation of Circadian Responses to Light Treatment

昼夜节律对光治疗的反应的适应

• 批准号: 7655082
• 负责人: Jeanne F Duffy
• 金额: $ 69.88万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7655082
• 关键词: Achievement; Acute; Advanced Sleep Phase Syndrome; Affect; Animals; Arousal; Attention; Brain; Circadian Rhythm Sleep Disorders; Circadian Rhythms; Data; Delayed Sleep Phase Syndrome; Electroencephalography; Environmental Exposure; Exposure to; Eye Movements; Hour; Human; Incidence; Jet Lag Syndrome; Laboratories; Light; Light Adaptations; Lighting; Measures; Melatonin; Neurologic; Pattern; Performance; Phase; Phototherapy; Physiological; Plasma; Property; Recording of previous events; Research; Seasons; Sleep Wake Cycle; Stimulus; Structure; System; Testing; Time; alertness; base; circadian pacemaker; field study; improved; light effects; light intensity; light treatment; neurobehavioral; primary outcome; public health relevance; research study; response; secondary outcome; shift work

DESCRIPTION (provided by applicant): Light is the most potent stimulus to shift the phase of the endogenous circadian timing system. If properly timed, it is effective in the treatment of circadian phase misalignment as seen in circadian rhythm sleep disorders (e.g., delayed sleep phase syndrome, advanced sleep phase syndrome, non-24-hour sleep-wake cycle, jet lag, and shift work). In order to optimize the properties of light exposure to activate neurological systems such as resetting of the endogenous circadian pacemaker, multiple variables of light stimuli have extensively been investigated (timing, intensity, wavelength, duration, number, and pattern of exposure). Interestingly, however, the effect of prior photic history on the sensitivity of the circadian timing system to light stimuli has received little attention. Animal experimental research has demonstrated that the circadian resetting response to a light stimulus can be reduced by a preceding non-saturating stimulus and recent research has also shown some evidence of modulation of melatonin suppression to prior lighting conditions in humans, both in the field and under controlled laboratory lighting conditions. In our preliminary data, we have demonstrated that prior photic history affects the sensitivity of circadian timing system, in that it modulates the strength of melatonin suppression and also the phase shifting response to light exposure. PUBLIC HEALTH RELEVANCE: Defining the influence of prior photic history on the circadian timing system will enable the optimization of light therapy in the treatment of circadian phase misalignment. Potentiating the photic sensitivity of the circadian pacemaker would facilitate rapid achievement of larger phase-shifts in response to light stimuli. Moreover, it may allow the use of a lower intensity of a light stimulus and/or a shorter duration of a light stimulus to achieve a similar effect. The understanding of the effects of prior photic history could help explain the ability of the circadian system to adapt to changes in natural outside light intensities across the seasons and at different latitudes.

描述（由申请人提供）：光是移动内源性昼夜节律定时系统相位的最有效刺激。如果适当的时间，则可以有效治疗昼夜节律睡眠障碍（例如，延迟睡眠期综合征，晚期睡眠期综合征，非24小时睡眠效果周期，喷气滞后和换档工作）的昼夜节相未对准。为了优化光暴露于激活神经系统的特性，例如重置内源性昼夜节奏起搏器，已经广泛研究了光刺激的多个变量（时间，时间，强度，波长，持续时间，持续时间，数量和暴露模式）。然而，有趣的是，先前的光学历史对昼夜节律对轻刺激的敏感性的影响很少受到关注。动物实验研究表明，先前的不饱和刺激可以降低昼夜节律对光刺激的反应，最近的研究还显示了一些证据表明，在野外和受控的实验室照明条件下，在人类的先前照明条件下抑制了褪黑激素的抑制作用。在我们的初步数据中，我们已经证明了先前的光学历史会影响昼夜节律系统的敏感性，因为它调节了褪黑激素抑制的强度以及对光暴露的相位转移反应。公共卫生相关性：定义先前的光学历史对昼夜节律定时系统的影响将使光疗在治疗昼夜节期错位时的优化。增强昼夜节律起搏器的光敏敏感性将促进响应光刺激的快速实现。此外，它可以允许使用较低的光刺激强度和/或较短的光刺激持续时间来实现相似的效果。对先前的光学历史影响的理解可以帮助解释昼夜节律适应整个季节和不同纬度的自然外部光强度变化的能力。