Conduct Disorder & Depression in Girls: Precursors, Development and Comorbidity

品行障碍

• 批准号: 7835526
• 负责人: ROLF LOEBER
• 金额: $ 160.94万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7835526
• 关键词: Address; Adolescence; Adolescent; African American; Age; Aggressive behavior; Alcohol or Other Drugs use; American; Anxiety; Area; Assertiveness; Attention deficit hyperactivity disorder; Basic Behavioral Science; Behavior; Behavioral Symptoms; Biological; Body Image; Borderline Personality Disorder; Childhood; Clinical Research; Cognition; Communities; Comorbidity; Conduct Disorder; DSM-IV; Data; Deltastab; Depressive disorder; Development; Devices; Disease; Dysthymic Disorder; Early identification; Emotional; Esthesia; European; Family; Fathers; Feeling suicidal; Female; Female Adolescents; Funding; Gender; Impairment; Income; Individual; Individual Differences; Intervention; Knowledge; Lead; Link; Longitudinal Studies; Major Depressive Disorder; Maps; Mediating; Mental Depression; Minor; Modeling; Mood Disorders; Morbidity - disease rate; Mothers; National Institute of Mental Health; Neighborhoods; Participant; Pathway interactions; Pattern; Phase; Phenotype; Post-Traumatic Stress Disorders; Prevention; Prevention program; Preventive; Preventive Intervention; Problem behavior; Prospective Studies; Psychopathology; Research; Risk; Sampling; Schools; Screening procedure; Self-control as a personality trait; Somatization Disorder; Strategic Planning; Subgroup; Symptoms; Syndrome; Testing; Violence; Woman; base; burden of illness; depressive symptoms; disorder risk; early childhood; early onset; girls; high risk; high risk sexual behavior; informant; minor depressive disorder; peer; public health relevance; satisfaction; social; social cognition; trait; young adult

DESCRIPTION (provided by applicant): Preventive interventions depend in large part on the availability of reliable and specific information about the development of psychopathology. Three of the priority areas for clinical research identified in the 2007/2008 NIMH Strategic Plan are the 1) prediction of individuals at risk for developing disease; 2) personalization of knowledge about individual biological, environmental and social factors to better personalize interventions; and 3) participation of the diversity of people and settings in clinical research The Pittsburgh Girls Study (PGS), a large-scale (n=2,451), longitudinal study of a representative, urban sample of African American and European American girls, is uniquely poised to illuminate each of these topic areas as they pertain to Conduct Disorder (CD) and Major Depressive Disorder (MDD): two disorders that generate the greatest amount of morbidity among adolescent females and contribute the largest portion to the global burden of disease among women (Murray & Lopez. 1997). In particular, the PGS aims to predict female CD and MDD by building developmental models of risk and protection from the early identification of individual vulnerabilities that serve as childhood precursors to disorders, and the contexts in which such vulnerabilities are more likely to lead to disorder, by operationalizing sub-syndromal phenotypes of disorders, and by examining developmental changes in the pattern of comorbid conditions. Prediction will be based on multiple annual assessments of this racially and economically diverse sample with high rates of participant retention (average of 94 percent over 7 waves). Thus far, we have generated data on the onset, stability and developmental course of DSM-IV symptoms for CD and MDD and a broad range of other disorders. We also have assessed potential moderating and mediating factors on the development of symptomatology in girls. We are seeking funds to continue this prospective study through adolescence with five annual assessments of the girls and their mothers and fathers. The girls will be aged 13-16 in wave 1, and aged 17-20 years in wave 5. The planned assessments, when linked to the developmental data already collected during childhood, will elucidate precursors to CD and MDD in adolescence, their sub-syndromal phenotypes, common patterns of comorbidity, and risk, promotive and protective factors associated with transitions from precursor, to sub-syndrome, to disorder, and to comorbid disorders. The study is relevant for understanding ethnic disparities in the manifestation of CD and MDD and can serve as a building block for personalized, preventive and remedial treatments to be developed for specific subgroups of girls at risk of CD, MDD, their co-occurrence, and comorbidity with other disorders. PUBLIC HEALTH RELEVANCE: The proposed study will provide information on specific emotional and behavioral problems assessed in young girls that are markers for later serious problems in adolescence and young adulthood. The study also examines family, peer, school, and neighborhood factors that increase or reduce these risks. The diversity of the participants in this community sample (e.g. equal numbers of African American and European American girls, broad range of income levels) will allow information to be gathered about early and ongoing risks and problems that are more important for different subgroups, which can serve as building blocks for screening devices and the prevention of adolescent emotional and behavioral problems.

描述（申请人提供）：预防干预措施很大程度上取决于有关心理病理发展的可靠和特定信息的可用性。 2007/2008 NIMH战略计划中确定的临床研究的三个优先领域是1）对患病风险的个人的预测； 2）个性化有关个人生物，环境和社会因素的知识，以更好地个性化干预措施； 3）参与人们和环境参与临床研究的参与匹兹堡女孩研究（PGS），一个大规模的（n = 2,451），对代表的非洲裔美国和欧美女孩的城市样本的纵向研究是独特地阐明这些主题领域的独特之处，以使他们的各种障碍（CD）的障碍（CD）造成了障碍（CD），并且是多种障碍（CD），并且是毫无疑问的。青少年女性之间的发病率，对妇女的全球疾病负担贡献了最大的部分（Murray＆Lopez。1997）。特别是，PGS旨在通过建立风险和保护的发展模型来预测女性CD和MDD，以免早期确定为疾病的童年前体，以及这种脆弱性更有可能导致混乱的环境，通过操作疾病的疾病综合表型，并通过疾病的发展范围来进行综合范围的变化。预测将基于对这种种族和经济上不同样本的多次年度评估，并且参与者保留率很高（在7次波浪中平均为94％）。到目前为止，我们已经生成了CD和MDD的DSM-IV症状的发作，稳定性和发育过程以及广泛的其他疾病的数据。我们还评估了有关女孩症状发展的潜在调节和调解因素。我们正在寻求资金通过青春期继续进行这项前瞻性研究，并对女孩及其母亲和父亲进行五次年度评估。 The girls will be aged 13-16 in wave 1, and aged 17-20 years in wave 5. The planned assessments, when linked to the developmental data already collected during childhood, will elucidate precursors to CD and MDD in adolescence, their sub-syndromal phenotypes, common patterns of comorbidity, and risk, promotive and protective factors associated with transitions from precursor, to sub-syndrome, to disorder, and to合并症。该研究与了解CD和MDD表现的种族差异有关，可以作为个性化，预防性和补救治疗的基础，以开发为具有CD，MDD风险的特定女孩亚组，其共同存在，以及与其他疾病的合并症。公共卫生相关性：拟议的研究将提供有关年轻女孩评估的特定情绪和行为问题的信息，这是后来在青春期和成年期间严重问题的标志。该研究还研究了增加或降低这些风险的家庭，同伴，学校和邻里因素。该社区样本中参与者的多样性（例如，相等数量的非洲裔美国和欧美女孩，广泛的收入水平）将允许收集有关早期和持续的风险和问题的信息，这些风险和问题对不同的亚组更为重要，这可以作为筛查设备的构建障碍以及预防青少年情绪和行为问题。