MRI AND VULNERABILITY TO PSYCHOSIS

MRI 与精神病脆弱性

• 批准号: 2251421
• 负责人: GEORGE BARTZOKIS
• 金额: $ 7.43万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-04-01 至 1999-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2251421
• 关键词: attention; auditory stimulus; brain imaging /visualization /scanning; brightness discrimination; cognition; hippocampus; human subject; long term memory; magnetic resonance imaging; memory; neural information processing; neuroanatomy; neuropsychological tests; performance; photostimulus; psychomotor reaction time; schizophrenia; sensory discrimination; stimulus /response; verbal learning; visual stimulus

This research will examine relationships between brain structure and cognitive performance in young schizophrenic patients. The core research hypothesis is that deficits in transferring information into long-term memory in schizophrenia are related to hippocampal volume. The specificity of this association will be evaluated through multivariate analysis of other brain structures and other information-processing tasks. The project piggy-backs on an ongoing longitudinal study of schizophrenic subjects with a recent first episode of psychosis, taking advantage of the numerous features of that project including excellent diagnostic evaluation, ongoing careful assessment with specialized information-processing and neuropsychological measures, and a well-characterized comparison sample of normals. The project will use high-resolution magnetic resonance imaging (MRI) and state-of-the-art measures of memory, early information- processing components, and attention. Both the cognitive neuropsychological and brain morphological measures will be obtained during a period of symptomatic stability early in the course of illness, and patients will be treated with a standardized medication protocol. Thus, findings will not be confounded by secondary effects of acute or long-term medication usage, clinical state, or other factors associated with chronicity. The project builds on literature suggesting that transfer to long-term memory is functionally related to the hippocampus and that working memory is related to both prefrontal cortex and hippocampus. Pilot data confirmed a significant correlation between hippocampal volume and one measure of the impact of distraction on memory. The current project addresses a number of methodological limitations in our previous pilot work, including highly variable time lapses between cognitive and MR assessments, lack of whole brain measures, variance in time since illness onset, and use of only limited memory assessment.

这项研究将探讨大脑结构与 年轻精神分裂症患者的认知表现。核心研究 假设是在将信息转化为长期的过程中存在缺陷 精神分裂症患者的记忆力与海马体积有关。特异性 这种关联性将通过多变量分析进行评估 其他大脑结构和其他信息处理任务。项目 依托一项正在进行的精神分裂症受试者纵向研究 最近首次发作精神病，利用大量 该项目的特点包括出色的诊断评估， 通过专门的信息处理和持续的仔细评估 神经心理学测量，以及一个充分表征的比较样本 法线。该项目将使用高分辨率磁共振成像 （MRI）和最先进的记忆测量、早期信息- 加工元件，注意事项。两者的认知 将获得神经心理学和大脑形态学测量 在病程早期症状稳定的时期， 患者将接受标准化的药物治疗方案。 因此，研究结果不会因急性或 长期用药、临床状态或其他相关因素 与慢性。该项目建立在文献的基础上，表明转移 长期记忆在功能上与海马体有关 工作记忆与前额皮质和海马体有关。飞行员 数据证实海马体积与 衡量分心对记忆影响的一种方法。当前项目 解决了我们之前试点中的一些方法学限制 工作，包括认知和 MR 之间高度可变的时间间隔 评估、缺乏全脑测量、患病后时间差异 发作，并且仅使用有限的记忆评估。

项目成果

Long acting injection versus oral risperidone in first-episode schizophrenia: differential impact on white matter myelination trajectory.

• DOI: 10.1016/j.schres.2011.06.029
• 发表时间: 2011-10
• 期刊: SCHIZOPHRENIA RESEARCH
• 影响因子: 4.5
• 作者: Bartzokis, George;Lu, Po H.;Amar, Chetan P.;Raven, Erika P.;Detore, Nicole R.;Altshuler, Lori L.;Mintz, Jim;Ventura, Joseph;Casaus, Laurie R.;Luo, John S.;Subotnik, Kenneth L.;Nuechterlein, Keith H.
• 通讯作者: Nuechterlein, Keith H.

Prevalent iron metabolism gene variants associated with increased brain ferritin iron in healthy older men.

• DOI: 10.3233/jad-2010-1368
• 发表时间: 2010
• 期刊: Journal of Alzheimer's disease : JAD
• 作者: Bartzokis G;Lu PH;Tishler TA;Peters DG;Kosenko A;Barrall KA;Finn JP;Villablanca P;Laub G;Altshuler LL;Geschwind DH;Mintz J;Neely E;Connor JR
• 通讯作者: Connor JR

Impact on intracortical myelination trajectory of long acting injection versus oral risperidone in first-episode schizophrenia.

• DOI: 10.1016/j.schres.2012.06.036
• 发表时间: 2012-09
• 期刊: Schizophrenia research
• 影响因子: 4.5
• 作者: Bartzokis G;Lu PH;Raven EP;Amar CP;Detore NR;Couvrette AJ;Mintz J;Ventura J;Casaus LR;Luo JS;Subotnik KL;Nuechterlein KH
• 通讯作者: Nuechterlein KH

In vivo evidence of differential impact of typical and atypical antipsychotics on intracortical myelin in adults with schizophrenia.

• DOI: 10.1016/j.schres.2009.06.014
• 发表时间: 2009-09
• 期刊: SCHIZOPHRENIA RESEARCH
• 影响因子: 4.5
• 作者: Bartzokis, George;Lu, Po H.;Stewart, Stephanie B.;Oluwadara, Bolanle;Lucas, Andrew J.;Pantages, Joanna;Pratt, Erika;Sherin, Jonathan E.;Altshuler, Lori L.;Mintz, Jim;Gitlin, Michael J.;Subotnik, Kenneth L.;Nuechterlein, Keith H.
• 通讯作者: Nuechterlein, Keith H.