MRI AND VULNERABILITY TO PSYCHOSIS

MRI 与精神病脆弱性

• 批准号: 2251421
• 负责人: GEORGE BARTZOKIS
• 金额: $ 7.43万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-04-01 至 1999-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2251421
• 关键词: attention; auditory stimulus; brain imaging /visualization /scanning; brightness discrimination; cognition; hippocampus; human subject; long term memory; magnetic resonance imaging; memory; neural information processing; neuroanatomy; neuropsychological tests; performance; photostimulus; psychomotor reaction time; schizophrenia; sensory discrimination; stimulus /response; verbal learning; visual stimulus

This research will examine relationships between brain structure and cognitive performance in young schizophrenic patients. The core research hypothesis is that deficits in transferring information into long-term memory in schizophrenia are related to hippocampal volume. The specificity of this association will be evaluated through multivariate analysis of other brain structures and other information-processing tasks. The project piggy-backs on an ongoing longitudinal study of schizophrenic subjects with a recent first episode of psychosis, taking advantage of the numerous features of that project including excellent diagnostic evaluation, ongoing careful assessment with specialized information-processing and neuropsychological measures, and a well-characterized comparison sample of normals. The project will use high-resolution magnetic resonance imaging (MRI) and state-of-the-art measures of memory, early information- processing components, and attention. Both the cognitive neuropsychological and brain morphological measures will be obtained during a period of symptomatic stability early in the course of illness, and patients will be treated with a standardized medication protocol. Thus, findings will not be confounded by secondary effects of acute or long-term medication usage, clinical state, or other factors associated with chronicity. The project builds on literature suggesting that transfer to long-term memory is functionally related to the hippocampus and that working memory is related to both prefrontal cortex and hippocampus. Pilot data confirmed a significant correlation between hippocampal volume and one measure of the impact of distraction on memory. The current project addresses a number of methodological limitations in our previous pilot work, including highly variable time lapses between cognitive and MR assessments, lack of whole brain measures, variance in time since illness onset, and use of only limited memory assessment.

这项研究将研究大脑结构与 年轻精神分裂症患者的认知表现。核心研究 假设是将信息转移到长期中的缺陷 精神分裂症的记忆与海马体积有关。特异性 该关联将通过多元分析来评估 其他大脑结构和其他信息处理任务。项目 在进行的精神分裂症受试者的纵向研究中的背包 有了最近的精神病第一集，利用了众多 该项目的功能包括出色的诊断评估， 不断仔细评估专门的信息处理和 神经心理学措施，以及良好的比较样本 正常。该项目将使用高分辨率磁共振成像 （MRI）和最先进的记忆措施，早期信息 - 处理组件和注意力。认知 将获得神经心理学和大脑形态学措施 在疾病早期的症状稳定期间， 患者将通过标准化药物方案进行治疗。 因此，发现不会被急性或 长期用药，临床状态或其他相关因素 长期。该项目以文献为基础，表明转移 长期记忆在功能上与海马相关， 工作记忆与前额叶皮层和海马都有关。飞行员 数据证实了海马体积和 分散注意力对记忆的影响的一种度量。当前项目 在我们以前的飞行员中解决了许多方法上的限制 工作，包括认知和MR之间的高度差异时间 评估，缺乏全脑措施，时间差异 发作，仅使用有限的内存评估。

项目成果

Long acting injection versus oral risperidone in first-episode schizophrenia: differential impact on white matter myelination trajectory.

• DOI: 10.1016/j.schres.2011.06.029
• 发表时间: 2011-10
• 期刊: SCHIZOPHRENIA RESEARCH
• 影响因子: 4.5
• 作者: Bartzokis, George;Lu, Po H.;Amar, Chetan P.;Raven, Erika P.;Detore, Nicole R.;Altshuler, Lori L.;Mintz, Jim;Ventura, Joseph;Casaus, Laurie R.;Luo, John S.;Subotnik, Kenneth L.;Nuechterlein, Keith H.
• 通讯作者: Nuechterlein, Keith H.

Prevalent iron metabolism gene variants associated with increased brain ferritin iron in healthy older men.

• DOI: 10.3233/jad-2010-1368
• 发表时间: 2010
• 期刊: Journal of Alzheimer's disease : JAD
• 作者: Bartzokis G;Lu PH;Tishler TA;Peters DG;Kosenko A;Barrall KA;Finn JP;Villablanca P;Laub G;Altshuler LL;Geschwind DH;Mintz J;Neely E;Connor JR
• 通讯作者: Connor JR

Impact on intracortical myelination trajectory of long acting injection versus oral risperidone in first-episode schizophrenia.

• DOI: 10.1016/j.schres.2012.06.036
• 发表时间: 2012-09
• 期刊: Schizophrenia research
• 影响因子: 4.5
• 作者: Bartzokis G;Lu PH;Raven EP;Amar CP;Detore NR;Couvrette AJ;Mintz J;Ventura J;Casaus LR;Luo JS;Subotnik KL;Nuechterlein KH
• 通讯作者: Nuechterlein KH

In vivo evidence of differential impact of typical and atypical antipsychotics on intracortical myelin in adults with schizophrenia.

• DOI: 10.1016/j.schres.2009.06.014
• 发表时间: 2009-09
• 期刊: SCHIZOPHRENIA RESEARCH
• 影响因子: 4.5
• 作者: Bartzokis, George;Lu, Po H.;Stewart, Stephanie B.;Oluwadara, Bolanle;Lucas, Andrew J.;Pantages, Joanna;Pratt, Erika;Sherin, Jonathan E.;Altshuler, Lori L.;Mintz, Jim;Gitlin, Michael J.;Subotnik, Kenneth L.;Nuechterlein, Keith H.
• 通讯作者: Nuechterlein, Keith H.