CENTER FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES: RESEARCH ON RESISTANT BACTERIA

传染病结构生物学研究中心：耐药细菌研究

• 批准号: 10788157
• 负责人: KARLA SATCHELL
• 金额: $ 137.75万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10788157
• 关键词: 3-Dimensional; Bacterial Drug Resistance; Basic Science; Biological; Biomedical Research; Categories; Communicable Diseases; Emerging Communicable Diseases; Gram-Negative Bacteria; Gram-Positive Bacteria; Molecular; National Institute of Allergy and Infectious Disease; Organism; Proteins; Research; Research Project Grants; Research Support; Role; Structure; Technology; bacterial resistance; pathogen; priority pathogen; programs; structural biology; three dimensional structure; 3-Dimensional; Bacterial Drug Resistance; Basic Science; Biological; Biomedical Research; Categories; Communicable Diseases; Emerging Communicable Diseases; Gram-Negative Bacteria; Gram-Positive Bacteria; Molecular; National Institute of Allergy and Infectious Disease; Organism; Proteins; Research; Research Project Grants; Research Support; Role; Structure; Technology; bacterial resistance; pathogen; priority pathogen; programs; structural biology; three dimensional structure

To apply state-of-the-art, high-throughput structural biology technologies to experimentally characterize the three-dimensional atomic structure of targeted proteins on the NIAID Category A-C priority pathogens list and organisms causing emerging and re-emerging infectious diseases. This program also supports research projects that utilize the 3D structure information and experimental approaches to better characterize the molecular functional role of protein targets. The primary focus of the Center is pathogen proteins that are expected to have an important biological role and a potential impact on biomedical research.

为了应用最先进的高通量结构生物学技术来实验表征NIAID类别A-C优先病原体清单上靶向蛋白的三维原子结构，并引起出现并重新出现感染性疾病。该计划还支持利用3D结构信息和实验方法的研究项目，以更好地表征蛋白质靶标的分子功能作用。该中心的主要重点是病原体蛋白，预计将对生物医学研究具有重要的生物学作用并潜在影响。