Behavioral Sleep Medicine: Training in Sleep and Aging

行为睡眠医学：睡眠与衰老培训

基本信息

批准号：
10729753
负责人：
Michael Lloyd Perlis
金额：
$ 18.22万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-06-01 至 2028-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10729753
关键词：
Achievement Acute Adult Age Aging Alzheimer&apos s disease patient Archives Area Arizona Award Behavioral Benefits and Risks Books Cardiovascular Diseases Cellular Phone Chronic Chronic Insomnia Chronobiology Clinical Clinical Services Collaborations Data Data Set Data Sources Databases Dedications Development Dose Education Educational process of instructing Elderly Environment Exhibits Fatigue Foundations Frustration Funding Future Generations Geography Goals Grant Hand Hypertension Immunosuppression Impaired cognition Impairment Incidence Individual Industry Internet Investigation Learning Longevity Longitudinal Studies Maintenance Mediating Medical Medicine Mental Depression Mentors Mentorship Meta-Analysis Mid-Career Clinical Scientist Award (K24)Morbidity - disease rate Natural History Online Systems Outcome Paper Parkinson Disease Patient Self-Report Patients Peer Review Pennsylvania Pharmaceutical Preparations Pilot Projects Placebo Effect Placebos Prevalence Psychiatry Psychological reinforcement Public Health Quality of life Recovery Regimen Relapse Reporting Research Research Personnel Risk Running Scientist Secure Series Services Severity of illness Sleep Sleep Disorders Sleep disturbances Sleeplessness Source Substance abuse problem Summary Reports Surveys Symptoms System Text Time Training Universities Vulnerable Populations Work affective disturbance age effect age related beneficiary biopsychosocial blood glucose regulation career cohort commercial application cost data archive data de-identification data integration data portal digital diverse data epidemiology study expectation experience follow-up health care service utilization hypnotic indexing instrument lectures medical specialties middle age mortality multiple datasets patient oriented patient oriented research programs recruit response screening sleep health smart speaker symposium symptom cluster treatment response zolpidem

项目摘要

ABSTRACT Goals: Dr. Perlis requests K24 support to: 1) maintain and expand his mentoring of junior investigators in the area of behavioral sleep medicine (BSM) and in the biopsychosocial approach to the study of insomnia; and 2) expand his program of research on sleep and aging. Background: Dr. Perlis has been involved in patient-oriented research since his late-20’s. He has been the beneficiary of exceptional mentorship and has carried forward this tradition over the entirety of his career. His research, while narrow in focus, extends from basic to patient-oriented to epidemiologic studies. His work includes 175 peer reviewed articles, 38 chapters, and three books. Four of the chapters are in our field’s flagship text book, the Principles and Practice of Sleep Medicine. The work has been highly impactful (H-Index of 68 with over 19,000 citations) and has earned him the SBSM’s Peter Hauri Lifetime Achievement award, nominations for the SRS’s Mary Carskadon Education Award, and the SBSM’s “Champion of BSM” Award. Environment: The University of Pennsylvania is one of the nation’s premier centers for sleep and chronobiology research and sleep medicine / behavioral sleep medicine clinical services. As such, it has much to offer both the PI and his trainees. Development Activities: The core activity for the mentor’s professional development will be the implementation of a 2nd generation of monthly seminar series focused on Sleep and Aging. This series will be co-hosted with Dr. Michael Grander as part of the University of Arizona’s Essential Topics in Behavioral Sleep Medicine Lecture Series. Leading scientists will be invited to discuss their ideas with respect to the effects of aging on sleep. These lectures will be offered as video conferences (open to all at no cost) and will be archived so that they may be accessed into the foreseeable future. During the K24 time frame, Dr. Perlis will also complete the development of an open access sleep health screener and a sleep tracker app. Both will be setup to capture data from thousands of individuals. Both will serve as data archives. Research: The candidate has created a collaborative network to conduct archival analysis with Jr. Investigators using his NIA supported: 1) natural history of insomnia databases and 2) partial reinforcement of medical treatment of insomnia databases (n=3). Additionally, his trainees and collaborators will have access to his programs’ recruitment database (n=5000+), his ISI in psychiatry screening database (n=3,000), a risk benefit network meta-analysis database (PI: J. Cheung), his newly established screener and tracker databases, and three industry databases (two of which will be used to profile sleep in patients with Alzheimer’s and Parkinson’s disease; one of which will be used to profile acute and chronic placebo response in patients with insomnia, with a focus on age effects on placebo responding). The individuals invited to analyze one or more of the 12 databases will have specialty areas apart from the PI, and thus will serve as an opportunity for the PI to both teach and learn. A conference will be held in the 5th year of this award for all collaborators and trainees. Significance: This K24 will support Dr. Perlis’ efforts to promote and mentor patient-oriented research, with a focus on aging effects on sleep continuity.

抽象的目标：Perlis 博士请求 K24 支持：1）维持并扩大他对初级研究人员的指导行为睡眠医学（BSM）领域和失眠研究的生物心理社会方法；2）扩大他在睡眠和衰老方面的研究项目背景：Perlis 博士一直致力于以患者为中心的研究。他从 20 多岁起就开始从事研究，一直受益于卓越的指导，并将这一点发扬光大。他的研究虽然关注范围狭窄，但从基础扩展到以患者为导向。他的著作包括 175 篇同行评审文章、38 章和三本书。这些章节收录在我们领域的旗舰教科书《睡眠医学的原理与实践》中。极具影响力（H 指数为 68，被引用次数超过 19,000 次），并为他赢得了 SBSM 的 Peter Hauri 终身奖成就奖、SRS 的 Mary Carskadon 教育奖提名以及 SBSM 的“冠军” BSM”环境奖：宾夕法尼亚大学是美国首屈一指的睡眠和健康中心之一。时间生物学研究和睡眠医学/行为睡眠医学临床服务。为 PI 及其学员提供发展活动：导师专业的核心活动。发展将是实施第二代每月研讨会系列，重点关注睡眠和该系列将与 Michael Grander 博士共同主持，作为亚利桑那大学 Essential 的一部分。行为睡眠医学讲座系列的主题将邀请顶尖科学家与我们讨论他们的想法。关于衰老对睡眠的影响这些讲座将以视频会议的形式提供（免费向所有人开放）。成本）并将被存档，以便在可预见的未来内可以访问它们， Perlis 博士还将完成开放式睡眠健康筛查仪和睡眠追踪应用程序的开发。两者都将被设置为捕获来自数千人的数据。候选人创建了一个协作网络，使用他的 NIA 与 Jr. Investigators 进行档案分析支持：1）失眠自然史数据库和2）失眠药物治疗的部分强化此外，他的学员和合作者将可以访问他的项目的招聘情况。数据库（n=5000+），他的精神病学筛查数据库中的 ISI（n=3,000），风险收益网络荟萃分析数据库（PI：J. Cheung），他新建立的筛选器和跟踪器数据库，以及三个行业数据库（其中两个将用于分析阿尔茨海默病和帕金森病患者的睡眠情况；其中一个将用于分析阿尔茨海默病和帕金森病患者的睡眠情况；用于分析失眠患者的急性和慢性安慰剂反应，重点关注年龄对失眠的影响（安慰剂回应）受邀分析 12 个数据库中的一个或多个的个人将具有专业知识。 PI 以外的领域，因此将成为 PI 教学和学习的机会。将于该奖项颁发的第五年为所有合作者和学员举办意义：本次 K24 将支持 Dr. 玻璃市致力于促进和指导以患者为中心的研究，重点关注衰老对睡眠连续性的影响。

项目成果

期刊论文数量（25）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Sleep Continuity, Sleep Related Daytime Dysfunction, and Problem Endorsement: Do These Vary Concordantly by Age?

DOI：
10.1080/15402002.2022.2124994
发表时间：
2023-07
期刊：
BEHAVIORAL SLEEP MEDICINE
影响因子：
3.1
作者：
Boyle, Julia T.;Rosenfield, Bradley;Di Tomasso, Robert A.;Moye, Jennifer;Bamonti, Patricia M.;Grandner, Michael;Vargas, Ivan;Perlis, Michael
通讯作者：
Perlis, Michael

Using placebos as an opioid-sparing method of pain management.

使用安慰剂作为一种节省阿片类药物的疼痛管理方法。

DOI：
10.1097/j.pain.0000000000000758
发表时间：
2017
期刊：
Pain
影响因子：
7.4
作者：
Jungquist,CarlaR;Perlis,MichaelL;Waghmarae,Romanth
通讯作者：
Waghmarae,Romanth

Insomnia symptoms predict longer COVID-19 symptom duration.

DOI：
10.1016/j.sleep.2022.11.019
发表时间：
2023-01
期刊：
SLEEP MEDICINE
影响因子：
4.8
作者：
Vargas, Ivan;Muench, Alexandria;Grandner, Michael A.;Irwin, Michael R.;Perlis, Michael L.
通讯作者：
Perlis, Michael L.

Measuring the Effects of Social Isolation and Dissatisfaction on Depressive Symptoms during the COVID-19 Pandemic: The Moderating Role of Sleep and Physical Activity.