Does social motivation in adolescence differentially predict the impact of childhood threat exposure on developing suicidal thoughts and behaviors

青春期的社会动机是否可以差异预测童年威胁暴露对自杀想法和行为的影响

• 批准号: 10785373
• 负责人: Andrea Pelletier Baldelli
• 金额: $ 18.5万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10785373
• 关键词: Adolescence; Adolescent; Affect; Age; Automobile Driving; Award; Behavior; Behavior assessment; Behavioral; Behavioral Mechanisms; Behavioral Paradigm; Brain; Cause of Death; Child Abuse and Neglect; Childhood; Clinical; Consult; Consultations; Corpus striatum structure; Cross-Sectional Studies; Data; Data Collection; Development; Doctor of Medicine; Doctor of Philosophy; Evaluation; Exhibits; Expenditure; Exposure to; Family; Feedback; Feeling suicidal; Female; Female Adolescents; Foundations; Functional Magnetic Resonance Imaging; Funding; Future; Goals; Illinois; Individual; Intervention; Interview; Investigation; Knowledge; Link; Longitudinal Studies; Male Adolescents; Measures; Mentored Patient-Oriented Research Career Development Award; Mentors; Modeling; Motivation; National Institute of Mental Health; Neurosciences; North Carolina; Parents; Pathway interactions; Patient Self-Report; Process; Psychopathology; Puberty; Punishment; Reporting; Research; Research Personnel; Rest; Risk; Risk Behaviors; Risk Factors; Role; Scientific Advances and Accomplishments; Self Assessment; Series; Severities; Social Interaction; Stress; Suicide; Suicide prevention; Symptoms; Testing; Time; Training; Training Support; Universities; Washington; Youth; aged; behavior measurement; biological sex; career; childhood adversity; cohort; community violence; experience; improved; multimodality; neural; neurobiological mechanism; neuroimaging; novel; peer; programs; recruit; sex; skill acquisition; skills; social; social stress; suicidal adolescent; suicidal behavior; suicidal risk

PROJECT SUMMARY This goal of this K23 Mentored Patient-Oriented Research Career Development Award is for the candidate to gain expertise in childhood threat exposure, social motivation (SM), and risk for suicidal thoughts and behaviors (STBs). Childhood threat exposure increases risk for STBs by affecting brain functioning associated interpersonal stress. Adolescence is filled with interpersonal stress; yet, not all adolescents with childhood threat exposure experience STBs, indicating that additional factors exacerbate risk. Identifying additional factors that interact with threat to increase STBs is imperative for identifying novel suicide prevention target mechanisms. This project will identify whether SM represents an additional factor that moderates the link between childhood threat exposure and STBs. Training objectives for this award will include skill acquisition in: (1) Developmental psychopathology models of childhood threat exposure and SM, (2) Neurobiological and behavioral mechanisms of risk for STBs, and (3) Advanced intensive time series modeling of brain connectivity. Training will facilitate the ability to conduct a study characterizing self-report, brain, and behavioral measures of SM in adolescents (Aim 1) to examine whether maladaptive social motivation strengthens the link between threat exposure and STBs (Aim 2). A final exploratory Aim 3 will allow for a preliminary investigation into how puberty, biological sex, and age further moderate the interaction between threat exposure and SM on STBs. This study will leverage two R01 projects to test Aims in two Cohorts; Cohort 1 (n = 220) includes early adolescent females aged 9 – 16, while Cohort 2 (n = 275) consists of adolescent male and females aged 15- 18. Experts from the University of North Carolina at Chapel Hill, Washington University St. Louis, and the University of Illinois Urbana-Champaign will mentor and consult with the candidate on the 3 training goals of this project: Margaret Sheridan Ph.D. & Adam Miller Ph.D. (Co-primary mentors), along with Karen Rudolph Ph.D., Deanna Barch Ph.D., Katie Gates, Ph.D. (Scientific Advisors), and Eva Telzer, Ph.D. and Joan Luby, M.D. (Consultants). This award provides the necessary training to become a unique, transdisciplinary researcher at the intersection of clinical, social, and developmental neuroscience. In consultation with the mentors, the candidate will use the training and the results of the research to inform the next steps in the candidate’s program of research on childhood adversity, social motivation, and risk for STBs during adolescence. Training and results from this award will also inform future R01 submission.

项目概要 K23 指导的以患者为导向的研究职业发展奖的目标是为候选人 获得有关儿童威胁暴露、社会动机 (SM) 和自杀念头风险的专业知识 儿童时期的威胁暴露会影响相关的大脑功能，从而增加发生 STB 的风险。 人际压力 青春期充满了人际压力，但并非所有的青少年都经历过童年时期。 威胁暴露经历机顶盒，表明其他因素加剧了风险。 与增加 STB 的威胁相互作用的因素对于确定新的自杀预防目标至关重要 该项目将确定 SM 是否代表调节这种联系的另一个因素。 该奖项的培训目标将包括以下方面的技能获取： (1) 儿童期威胁暴露和 SM 的发展精神病理学模型，(2) 神经生物学和 STB 风险的行为机制，以及 (3) 先进的大脑强化时间序列建模 培训将促进进行自我报告、大脑和行为研究的能力。 青少年 SM 测量（目标 1），以检验适应不良的社会动机是否加强了这种联系 威胁暴露和 STB 之间的关系（目标 2）。最终的探索性目标 3 将允许进行初步调查。 研究青春期、生物性别和年龄如何进一步调节威胁暴露与 SM 之间的相互作用 本研究将利用两个 R01 项目来测试两个队列 1（n = 220）中的目标； 9 – 16 岁的青春期女性，而第 2 组（n = 275）由 15 – 16 岁的青春期男性和女性组成 18. 来自北卡罗来纳大学教堂山分校、华盛顿大学圣路易斯分校和美国华盛顿大学的专家 伊利诺伊大学厄巴纳-香槟分校将就以下 3 个培训目标向候选人提供指导和咨询 该项目：Margaret Sheridan 博士和 Adam Miller 博士（联合主要导师）以及 Karen Rudolph 博士、Deanna Barch 博士、Katie Gates 博士（科学顾问）、Eva Telzer 博士和 Joan Luby， 医学博士（顾问）。该奖项提供了成为独特的跨学科的必要培训。 临床、社会和发育神经科学交叉领域的研究员。 在导师的指导下，候选人将利用培训和研究结果来指导下一步的工作 候选人关于童年逆境、社会动机和 STB 风险的研究计划 该奖项的培训和结果也将为未来的 R01 提交提供信息。