Applied Genomics in Infectious Diseases

传染病中的应用基因组学

• 批准号: 7673448
• 负责人: DAVID A. RELMAN
• 金额: $ 25.49万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7673448
• 关键词: Communicable Diseases; Genomics

DESCRIPTION (provided by applicant): The genomic revolution originated in the study of infectious agents, and it is destined to alter the way we diagnose, manage and prevent infectious diseases. This proposal presents a plan to train M.D., M.D. / Ph.D. and Ph.D. scholars as researchers in the pathogenesis, immunology, therapeutics and prevention of infectious diseases through the use of genomics. We propose to prepare all trainees-irrespective of whether they intend to conduct their research at the bench or from the bedside-in fundamentals of both genomics and applied clinical investigation, with the goal of fostering collaborations and enhancing the translation of scientific discoveries into clinical practice. The training program will be interdisciplinary, involving faculty from Infectious Diseases, Biochemistry, Biological Sciences, Gastroenterology, Genetics, Health Research and Policy, Medical Informatics, Microbiology and Immunology, Pathology, and Pediatrics. All fellows will train for at least 2 years. Each trainee will be encouraged to take courses in clinical research and in basic sciences related to genomics. Additionally, each trainee will complete a 2-year (75 hours) interdisciplinary core curriculum in applied genomics of infectious diseases. Beginning in the first year, each fellow will embark on an in-depth research project supervised by one or more of the Program's faculty; in many cases, joint mentoring will involve faculty from different disciplines. In this way, most research projects will be cross-disciplinary. Quarterly seminars by trainees and an annual research retreat will be held to promote interactions between program participants. Ph.D. candidates who have completed their thesis work and M.D. candidates who have completed their clinical training will be evaluated by the Program's Steering Committee and offered admission on the basis of exceptional academic record, faculty interviews and demonstrated interest in interdisciplinary research. Every effort will be made to attract minority candidates. 5 postdoctoral fellows are to be supported by the Program. While support will be guaranteed for 2 years, fellows will be encouraged to seek independent support after the first year. The program intends to meet a recognized need for clinician-scientists in Infectious Diseases who are trained in functional and applied genomics-a strength of Stanford University School of Medicine. Trainees are expected to graduate to academic faculty appointments or to research-oriented positions in federal government, public health or the biotechnology commercial sector.

描述（由申请人提供）：基因组革命起源于传染药的研究，它注定要改变我们诊断，管理和预防传染病的方式。该提案提出了培训医学博士，医学博士 /博士学位的计划。和博士学者是通过使用基因组学的发病机理，免疫学，治疗学和预防传染病的研究。我们建议所有学员是否打算在基因组学和应用临床研究的基本面进行研究，以便他们进行研究，以促进合作并增强科学发现转化为临床实践。该培训计划将是跨学科的，涉及传染病，生物化学，生物学，胃肠病学，遗传学，健康研究和政策，医学信息学，微生物学和免疫学，病理学和儿童的教师。所有研究员将训练至少两年。将鼓励每个学员参加临床研究和与基因组学有关的基础科学课程。此外，每个学员将在传染病的应用基因组学中完成2年（75小时）的跨学科核心课程。从第一年开始，每个研究员将开始由该计划的一个或多个教师监督的深入研究项目；在许多情况下，联合指导将涉及来自不同学科的教师。这样，大多数研究项目将是跨学科的。学员的季度研讨会和年度研究务虚会，以促进计划参与者之间的互动。博士该计划的指导委员会将评估完成论文工作的候选人以及完成临床培训的医学博士候选人，并根据出色的学术记录，教师访谈和对跨学科研究的兴趣进行评估。将尽一切努力吸引少数派候选人。该计划将支持5个博士后研究员。尽管将保证两年的支持，但鼓励研究员在第一年后寻求独立的支持。该计划旨在满足对经过功能和应用基因组学培训的传染病中临床医生的认可需求，这是斯坦福大学医学院的力量。预计学员将毕业于学术教师任命或以研究为导向的联邦政府，公共卫生或生物技术商业部门的职位。