Epidemiology and Biostatistics of Aging

老龄化流行病学和生物统计学

• 批准号: 7600561
• 负责人: Karen J. Bandeen-Roche
• 金额: $ 48.49万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7600561
• 关键词: Aging; Biometry; Epidemiology

DESCRIPTION (provided by applicant): This is an application for a 5-year renewal of an institutional training grant in the Epidemiology and Biostatistics of Aging, funded by NIA since 1996. This multidisciplinary training program's goals are to train outstanding predoctoral and postdoctoral candidates to lead the next generation of quantitative research scientists addressing the health problems of our aging population. This program is conducted jointly by epidemiologists and biostatisticians with a strong commitment to bringing together students in both disciplines to develop expertise in both the content areas and methodologies that are essential to the further development of the field. Students are trained as researchers who can conduct leading-edge descriptive, analytic and experimental studies and develop, implement and evaluate prevention programs to compress the morbidity experience of the aging population. The program is based in the Departments of Epidemiology and Biostatistics, but involves faculty from other departments throughout the Schools of Public Health, Medicine, and Nursing. A Program Director in Epidemiology, a Co-Director from Biostatistics, 5 Associate Directors from the two Departments, and 21 other core faculty members will serve as Advisors for the trainees. There is a core curriculum expected of predoctoral trainees, and customized to postdoctoral trainees. Trainees, half Epidemiology and half from Biostatistics, participate in biweekly research in progress conferences, seminars on aging, and practica specific to this program, and training dedicated to skills in multidisciplinary collaboration. Research experiences and mentors are selected to ensure high quality research worthy of peer-reviewed publication in aging research. We propose to continue to train students in epidemiologic and biostatistical method, and their application to important questions in the health status of older adults, including causes and consequences of chronic diseases, comorbidity, and disability. Students develop expertise in design and conduct of large-scale observational prospective studies; longitudinal data analysis; the genetic and molecular causes of age-related changes; the phenotype, consequences and etiology of frailty, and cognitive decline; statistical methods for the measurement and analysis of complex geriatric outcomes, such as frailty and disability; the social epidemiology of aging; and programs that translate research findings into effective prevention for older adults. We now propose to enrich and expand the emphases to include study in the design and conduct of clinical trials in older populations and the integration of physiology into longitudinal epidemiologic studies of the progression of health and disease. Trainees have been highly productive, gained substantial recognition for their research, and launched their careers in appealing positions with emphases on aging. Graduates will be effective leaders of multidisciplinary research teams tackling the health problems associated with the aging US population.

描述（由申请人提供）：这是对衰老的流行病学和生物统计学的机构培训补助金进行5年续签的申请，自1996年以来由NIA资助。这项多学科培训计划的目标是培训出色的典范和产后候选者和后代候选人，以使下一代研究的研究科学家对我们的健康问题进行定量研究的人群，我们为我们的衰老人群提供了解决问题。该计划是由流行病学家和生物统计学家共同开展的，他们坚定地致力于将两个学科的学生召集在一起，以在内容领域和方法论中发展专业知识，这对于该领域的进一步发展至关重要。对学生进行了培训的研究人员，他们可以进行领先的描述性，分析和实验研究，并开发，实施和评估预防计划，以压缩老龄化人群的发病率经验。该计划基于流行病学和生物统计学部门，但涉及整个公共卫生，医学和护理学校的其他部门的教师。流行病学计划主任，生物统计学的联合主任，两个部门的副董事和其他21位核心教师将担任学员的顾问。有核心学员的核心课程，并对博士后学员进行定制。学员，一半流行病学，一半来自生物统计学，参加了每两周的进展研究，衰老研讨会和特定于该计划的实践研讨会，以及致力于多学科合作技能的培训。选择研究经验和导师以确保高质量的研究值得在衰老研究中经过同行评审的出版物。我们建议继续培训学生的流行病学和生物统计学方法，并将其应用于老年人健康状况的重要问题，包括慢性疾病，合并症和残疾的原因和后果。学生在设计和进行大规模观察前瞻性研究方面发展专业知识；纵向数据分析；与年龄相关的变化的遗传和分子原因；脆弱的表型，后果和病因以及认知能力下降；用于测量和分析复杂的老年结局的统计方法，例如脆弱和残疾；衰老的社会流行病学；以及将研究结果转化为老年人有效预防的计划。现在，我们建议丰富和扩大重点，以在较老人群的临床试验设计和进行研究中进行研究，并将生理学整合到健康和疾病进展的纵向流行病学研究中。学员的生产力很高，对他们的研究获得了丰富的认可，并以吸引人的职位开始了他们的职业，重点是衰老。毕业生将成为跨学科研究团队的有效领导者，以解决与美国老年人口相关的健康问题。