Training in Basic Aging Research and Age-Related Disease

基础衰老研究和年龄相关疾病培训

• 批准号: 7600574
• 负责人: Judith Campisi
• 金额: $ 54.5万
• 依托单位: BUCK INSTITUTE FOR RESEARCH ON AGING
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7600574
• 关键词: Aging; Disease; Research; Training; age related

DESCRIPTION (provided by applicant): As the U.S. population ages, it has become increasingly important to understand the fundamental basis of aging and age-related disease. Age is the largest single risk factor for a panoply of diseases, including neurodegeneration, cancer, type II diabetes, osteoporosis and cardiovascular disease. Eliminating any one of these diseases will increase average years of healthy life (health span). Postponing, or decreasing the rate of, aging will retard the course of multiple age-related diseases and thus provide even greater increases in average health span. Thus, rational approaches to preventing or intervening in age-related disease will require an integrated basic research strategy: understanding the specific etiologies of these diseases, and understanding the basic mechanism of aging. Crucial to this strategy is our ability to train a cohort of scientists, knowledgeable in modern cell, molecular and physiological sciences, and committed and prepared to apply that knowledge to the problem of aging and age-related disease. This application proposes to create a unique and exciting new training program in aging research based on two ongoing programs, one at the Buck Institute for Age Research (PI: Dale Bredesen) and the other at the Lawrence Berkeley National Laboratory (LBNL)/University of California Berkeley (UCB) (PI: Judith Campisi). In the past four and seven years, these programs provided postdoctoral fellows with excellent training in basic aging and age-related disease research. We now propose to continue and expand these thriving programs by assembling one cohesive training program from outstanding scientists from these three Bay area institutions. As a recently designated NIA Nathan Shock Center for Aging and growing Institute focused on aging and age-related disease research, the Buck Institute is well-poised to lead this combined effort. The proposed new program will offer postdoctoral scientists unique and outstanding training for a career in aging research. In addition to benefiting from diverse faculty expertise in topics relevant to aging, age-dependent diseases, the program will provide trainees with access to superb facilities in genomics, proteomics and model systems. Trainees will gain skills in research design, critical thinking, and evaluation of new research findings through participation in courses, basic science and clinical research seminars, journal clubs and focused research meetings, in which their results will be discussed from both basic and applied perspectives. In addition, trainees will receive instruction in research ethics, as well as written and verbal skills to enrich their publications, grant proposals and oral presentations. Trainees will also have opportunities to meet and interact with current leaders in aging and age-related disease research through organized trainee-sponsored seminars and Institute sponsored symposia and courses. Thus, fellows in this program will gain state-of the-art training and knowledge in modern aging research, enabling them to embark on careers dedicated to understanding the bases for aging and age-related disease and devise strategies to improve the health span of the aging U.S. population.

描述（由申请人提供）：随着美国人口的年龄，了解衰老和与年龄有关的疾病的基本基础变得越来越重要。年龄是全体疾病的最大危险因素，包括神经退行性，癌症，II型糖尿病，骨质疏松症和心血管疾病。消除这些疾病中的任何一种都会增加健康寿命的平均年份（健康跨度）。衰老的延迟或降低率将阻碍多种年龄相关疾病的过程，从而在平均健康范围内增加增加。因此，预防或干预与年龄相关的疾病的合理方法将需要一体的基础研究策略：了解这些疾病的特定病因，并了解衰老的基本机制。对这一策略至关重要的是我们能够培训一系列科学家，在现代细胞，分子和生理科学方面知识渊博，并致力于将这些知识应用于衰老和与年龄有关的疾病的问题。该申请建议基于两个正在进行的计划创建一个独特而令人兴奋的新培训计划，以在老龄化研究中，一个在Buck Age Institute for Aga Research（PI：Dale Bredesen），另一个在劳伦斯·伯克利国家实验室（LBNL）/加利福尼亚大学伯克利分校（UCB）（UCB）（PI：Judith Campisi）。在过去的四年和七年中，这些计划为博士后研究员提供了在基本衰老和与年龄有关的疾病研究方面的出色培训。现在，我们建议通过从这三个湾区机构的杰出科学家组成一个凝聚力的培训计划来继续并扩大这些蓬勃发展的计划。作为最近指定的Nia Nathan衰老和成长研究所的Nia Nathan休克中心，专注于衰老和与年龄相关的疾病研究，Buck Institute经过良好的努力，以领导这一综合努力。拟议的新计划将为博士后科学家提供独特的培训，以实现老龄化研究的职业。除了受益于与衰老，依赖年龄依赖性疾病有关的主题方面的各种教师专业知识外，该计划还将为受训者提供基因组学，蛋白质组学和模型系统中精湛设施的访问权限。受训人员将通过参与课程，基础科学和临床研究研讨会，期刊俱乐部和集中的研究会议来获得研究设计，批判性思维和评估新研究结果的技能，从基础和应用的角度讨论他们的结果。此外，学员将获得有关研究道德的指导，以及书面和口头技能，以丰富其出版物，赠款建议和口头演讲。学员还将有机会通过有组织的学员赞助的研讨会和研究所赞助的研讨会和课程与现任老龄化和与年龄有关的疾病研究的现有领导者见面和互动。因此，该计划中的研究员将获得现代老化研究的最先进的培训和知识，使他们能够从事专门了解衰老和年龄相关疾病的基础的职业，并制定策略，以改善美国老龄化的美国人群的健康范围。