Molecular Pathogenesis of Infectious Diseases

传染病的分子发病机制

• 批准号: 7661350
• 负责人: Kathryn V Holmes
• 金额: $ 8.41万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7661350
• 关键词: Communicable Diseases; Molecular; Pathogenesis

DESCRIPTION (provided by applicant): This application is for the first competing renewal of our pre-doctoral training program on The Molecular Pathogenesis of Infectious Diseases at the University of Colorado School of Medicine. This emerging area of research encompasses molecular biological and biochemical studies on microbial virulence factors, host resistance mechanisms, regulation of gene expression during infection, structure-function analysis of microbial and host cell molecules that play key roles in infections, analysis of interactions of bacteria and viruses with differentiated host cells in vitro, and studies on bacterial and viral infections in animal models using either wild type or genetically modified strains of microbes and host animals. The highly interactive members of our training faculty have proven productivity for innovative research in these areas, successful research funding from NIH and other granting agencies, and extensive experience in training pre-doctoral students in the multidisciplinary approaches needed for cutting edge research on the pathogenesis of infectious diseases. In addition to performing their mentored research projects, our trainees will participate in a comprehensive program of didactic courses, seminars, journal clubs, and research-in-progress meetings which will train them to identify important new research questions, design well-controlled experiments using a wide variety of molecular, cellular and in vivo techniques, critically evaluate and present their results, and understand and apply principles of ethics to their research. Students are selected for appointment to this training program only after they have completed all of their required courses, passed their preliminary and comprehensive examinations and begun their dissertation research. The breadth of our integrated, interdepartmental training program will prepare students for innovative careers in academia or biotechnology. This dynamic new training program has been extremely successful. It has fostered new research collaborations and grants, improved the curriculum, and fostered interdisciplinary interactions among the pre-doctoral trainees. In the 4 years since our training program on the Molecular Pathogenesis of Infectious Diseases began, our training faculty increased from 19 to 21, and the steady state number of predoctoral trainees in faculty labs grew from 21 to 31. Currently this training grant provides only one year of support for 3 trainees each year. We request 4 positions in years 06-07 to provide a 2-year commitment for 1 of the 3 trainees appointed each year and 5 positions in years 08-10 to fund one additional trainee whose research will focus on molecular mechanisms of infection related to biodefense or emerging infectious disease agents.

描述（由申请人提供）：此申请是针对科罗拉多大学医学院传染病分子发病机理的第一次竞争续约。研究的这一新出现领域包括分子生物学和生化研究对微生物毒力因子，宿主抗性机制，感染过程中基因表达的调节，对微生物和宿主细胞分子的结构功能分析，这些分子在感染中起着关键作用，在感染中起着关键作用，以及使用细菌中的分化和病毒在体内的分化和病毒研究中发挥作用，并在体外进行分化，并在体外进行了差异，并研究了动物的类型研究，并在体内进行了杂种研究，并研究了动物的类型研究修饰的微生物菌株和宿主动物。我们培训学院的高度互动成员在这些领域的创新研究，NIH和其他授予机构的成功研究资金以及在培训博士前学生方面的丰富经验证明了生产力。除了执行指导的研究项目外，我们的学员还将参加一项完整的教学课程，研讨会，期刊俱乐部和进行研究的课程，这些课程将培训他们以确定重要的新研究问题，设计出良好的控制实验，设计良好的分子，细胞，细胞和体内技术，并在体内和概述和介绍他们的宗教和善良的研究和专业方面，并以他们的态度和介绍他们的宗教和原则。只有在完成所有必需的课程，通过初步和全面的考试并开始论文研究之后，才被选出该培训计划。我们综合的部门间培训计划的广度将使学生为学术界或生物技术的创新职业做好准备。这个动态的新培训计划非常成功。它促进了新的研究合作和赠款，改善了课程，并在博士前学员之间促进了跨学科的互动。自从我们关于传染病分子发病机理的培训计划开始的4年中，我们的培训教师从19个增加到21岁，而教师实验室中培训前学员的稳态数量从21岁提高到31。我们要求在06-07年的4年职位提供对每年任命的3名学员中的1名和08-10岁的5个职位的2年承诺，以资助一名额外的学员，其研究将重点放在与生物脱节或新兴感染性疾病药物有关的分子感染机制上。