TRAINING IN ORTHOPEDIC SKELETAL BIOLOGY

骨科骨骼生物学培训

• 批准号: 7667228
• 负责人: D Rick Sumner
• 金额: $ 16.21万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7667228
• 关键词: Biology; Orthopedics; Training; skeletal; Biology; Orthopedics; Training; skeletal

DESCRIPTION (provided by applicant): This is an application for integrated pre- and post-doctoral training support that will bring together cutting edge clinical strategies with experimental investigations on the mechanisms and biology of skeletal tissue repair and regeneration. The proposal is based in the skeletal biology program centered in the Department of Anatomy & Cell Biology at Rush University Medical Center in partnership with the Department of Orthopedic Surgery (which includes one of the premier clinical orthopedic groups in the country as well as an outstanding group of basic scientists). Faculty from two other clinical departments at Rush (Section of Rheumatology from the Department of Internal Medicine and the Department of Plastics & Reconstructive Surgery) are expected to participate as mentors or co-mentors. The objective of the proposed program is to provide education, training and research opportunities to doctoral students, postdoctoral fellows and medical students interested in academic careers in the multi-disciplinary area of skeletal biology. The program will emphasize mechanisms of skeletal repair and regeneration in order to direct training to basic biological research foundations for orthopedics, rheumatology and craniofacial surgery. We are requesting support for 3 graduate students, 2 post-doctoral fellows and 2 short-term research trainees. In addition to traditional PhD students and MD/PhD students, a special effort will be made to recruit students seeking combined MD/MS degrees. Although our MD/MS program is relatively new, all of the students who have participated are on a very encouraging track of becoming physician-scientists. We think this track is particularly important for students interested in surgical careers because of the extremely long clinical training requirements. Thus, emphasis on the MD/MS (as opposed to the MD/PhD) still permits a meaningful intense research experience, but adds only one year (as opposed to three years) to the entire training regimen. At the post-doctoral level, we plan to pay special attention to the recruitment of MDs and MD/PhDs. The short-term research trainee mechanism will be used as a way to provide an introduction to research for medical students who are still considering the MD/MS or MD/PhD option. We are taking this strategy to help bolster the number of physician-scientists in orthopedic skeletal biology. Relevance: This grant will help train scientists to improve healing of damaged bone and joints. Current orthopedic procedures are successful, but we hope to improve outcomes through a better understanding of the underlying pathologies and mechanisms the body uses to repair itself. Eventually, treatments will rely more on the body's natural ability at self-renewal and less on the use of artificial materials.

描述（由申请人提供）：这是综合前后训练后支持的申请，将尖端临床策略汇总在一起，并就骨骼组织修复和再生的机制和生物学进行实验研究。该提案基于与骨科外科系合作的骨骼生物学计划，该计划集中在拉什大学医学中心的解剖与细胞生物学系（其中包括该国最重要的临床骨科组之一以及一群杰出的基本科学家组）。 Rush的其他两个临床部门的教师（内科学系的风湿病学部分和塑料与重建手术系）预计将作为导师或合作者参与。拟议计划的目的是为博士生，博士后研究员和对骨骼生物学多学科领域的学术职业感兴趣的医学生提供教育，培训和研究机会。该计划将强调骨骼修复和再生的机制，以直接训练骨科，流变学和颅面手术的基本生物学研究基础。我们要求支持3名研究生，2名博士后研究员和2名短期研究受训者。除了传统的博士生和医学博士/博士学位学生外，还将做出特别的努力，以招募寻求合并MD/MS学位的学生。尽管我们的MD/MS计划相对较新，但所有参加的学生都在成为医师科学家的令人鼓舞的轨道。我们认为，由于非常长的临床培训要求，这条曲目对对手术职业感兴趣的学生尤为重要。因此，强调MD/MS（与MD/PHD相反）仍然允许有意义的激烈研究经验，但仅增加了一年（而不是三年），以使整个培训方案增加了一年（而不是三年）。在博士后，我们计划特别注意招募MDS和MD/PHD。短期研究学员机制将用作为仍在考虑MD/MS或MD/PHD选项的医学生提供介绍的一种方式。我们正在采取这种策略来帮助加强骨科骨骼生物学中医师科学家的数量。相关性：该赠款将帮助培训科学家改善受损骨骼和关节的治愈。当前的骨科程序是成功的，但我们希望通过更好地了解人体修复自身使用的基本病理和机制来改善结局。最终，治疗将更多地依赖人体自然的自我更新能力，而更少的是使用人造材料。