Training Program in Systemic Autoimmunity

系统性自身免疫培训计划

• 批准号: 7661374
• 负责人: George C Tsokos
• 金额: $ 12.49万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7661374
• 关键词: Autoimmunity; Training Programs

DESCRIPTION (provided by applicant): This is a new proposal of a training program in systemic autoimmunity at the Beth Israel Medical Deaconess Medical Center (BIDMC), Harvard Medical School (HMS). It requests support for two trainees each year who will spend at least two years in the program. Trainees will enter the program through one of the following tracks: Physicians who seek training in rheumatology or nephrology, physicians who enter other clinical fellowship programs including neurology and dermatology, physicians who have completed clinical training in a field relevant to systemic autoimmune diseases and PhDs with background in immunology, biochemistry and cell/molecular biology. The major criterion for selection will be evidence of commitment to the study of systemic autoimmune diseases. Through this training physicians will develop skills in immunology and biology/biochemistry, whereas PhDs will become familiar with clinical issues pertinent to the study of systemic autoimmune diseases. Research activities will span studies in human and animal T cells, B cells, NKT cells, macrophages, mast cells, costimulation, immune cell signaling, immune tolerance, control of cytokine expression and function, pertinent aspects of regional immunology and biology (kidney, skin and nervous system), human genetics, immunodeficiency, complement and immunomodulation. The chief method of instruction will involve personal involvement in a program of basic research under the close supervision of a senior scientist. Moreover, a structured program of didactic courses in research seminars, journal clubs, research presentations in national and international meetings and grant writing is in place. The primary facilities for training are at BIDMC and HMS-affiliated institutions. Graduating trainees will be able to plan, seek funding, and execute cutting edge research in systemic autoimmune diseases and will be properly tooled to develop new diagnostics and therapeutics. This program will develop top notch researchers in the study of systemic autoimmune diseases who will lead basic and clinical research in academic centers to advance the care of people suffering from these diseases.

描述（由申请人提供）：这是哈佛大学医学院（HMS）的贝丝以色列医疗执事医疗中心（BIDMC）的系统自身免疫培训计划的新建议。它要求每年对两名学员的支持，他们将在该计划中花费至少两年。学员将通过以下一条曲目之一进入该计划：寻求风湿病学或肾脏学培训的医师，参加其他临床奖学金计划的医生，包括神经病学和皮肤病学，医师，在与全身性自身免疫性疾病和PHDS有关的领域中完成临床培训的医生，具有不良的背景，生物生物学，生物学，生物学，生物学，生物学，摩擦于生物学。选择的主要标准将是致力于研究系统性自身免疫性疾病的证据。通过这项培训，医生将发展免疫学和生物学/生物化学的技能，而博士学位将熟悉与系统性自身免疫性疾病有关的临床问题。研究活动将涵盖人类和动物T细胞，B细胞，NKT细胞，巨噬细胞，肥大细胞，造成刺激，免疫细胞信号传导，免疫耐受性，控制细胞因子表达和功能的控制，区域免疫学和生物学（肾脏，皮肤和神经系统）的相关方面，人类遗传学，人类遗传学，免疫缺乏效率，互补，互补，免疫，和免疫肿瘤。在高级科学家的密切监督下，教学的主要方法将涉及个人参与基础研究计划。此外，已经制定了研究研讨会，期刊俱乐部，国际和国际会议的研究演讲以及赠款写作的结构化课程。培训的主要设施是在BIDMC和HMS附属机构进行的。即将毕业的学员将能够在系统性自身免疫性疾病中计划，寻求资金并执行最先进的研究，并将适当地使用新的诊断和治疗剂来进行适当的工具。该计划将在系统性自身免疫性疾病的研究中开发一流的研究人员，这些疾病将领导学术中心的基本和临床研究，以促进对患有这些疾病的人的护理。