hESC Resource and Training Core

hESC 资源和培训核心

• 批准号: 7538041
• 负责人: Thomas Schulz
• 金额: $ 25.37万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7538041
• 关键词: Access to Information; Arts; Award; BG01; BG02; BG03; Back; Cell Line; Cell Maintenance; Cells; Communities; Comparative Study; Condition; Conditioned Culture Media; Core Facility; Endoderm; Fibroblasts; Health Sciences; Home environment; Human Resources; Institution; Internet; Laboratories; Mesoderm; Modeling; Mus; Pilot Projects; Preclinical Drug Evaluation; Quality Control; Range; Research; Research Personnel; Resources; Role; Scientist; Site; Stem cells; System; Technical Expertise; Technology; Time; Training; Training Programs; USA Georgia; Universities; Visit; Week; Western Asia Georgia; Work; base; cell bank; density; design; human embryonic stem cell; member; new technology; progenitor; programs; relating to nervous system

The 'hESC Resource and Training Core1 (Core A) will be located in a new Core facility in the Paul D. Coverdell Center for Biomedical and Health Sciences at the University of Georgia. The Core will have three primary objectives: cell maintenance and distribution, including support for quality control This will be primarily built on new technologies developed for hESC culture and differentiation. hESCs will be grown in fully defined media under feeder free conditions. Three directed differentiation models will be offered: definitive endoderm, mesoderm and neural progenitors, The Core will also serve as a distribution center for hESCs adapted and grown in defined media, a resource that is currently not available to the hESC community. to provide state of the art training for new investigators wishing to establish hESC expertise An intensive 2 week laboratory based training program will be offered to investigators from the Southeast. This will involve aspects of culture in defined media and new technologies, such as large scale hESC culture and high density culture applicable for drug screening. These technologies are available due to advantages offered by the defined system. to function as a technical resource for the Southeastern hESC community The technical expertise of the Core will be accessible to the Southeast hESC community by direct one-onone contact, by access to information posted at the Program's web site, and through the facilitation of technical exchange through several additional mechanisms. Overall, the Core is designed to stimulate activity in hESC research in the Southeast and to enable investigators to enter the field by obtaining access to an intensive training program. The Core will be continually evaluating and introducing new technologies into its own range of activities. These will be offered to established investigators as part of the training program, or through direct dissemination of technical information. Discussions with leaders in the stem cell field from the Southeast indicate that the Core will serve a vital and much needed role in supporting hESC activities in the region.

'HESC资源和培训Core1（核心A）将位于Paul D的新核心设施中。 佐治亚大学生物医学和健康科学中心。 核心将有三个主要目标： 细胞维护和分发，包括支持质量控制 这将主要建立在用于HESC文化和分化的新技术上。 hESC会 在无馈物条件下在完全定义的媒体中生长。将三个定向分化模型是 提供：确切的内胚层，中胚层和神经祖细胞，核心也将作为分布 在定义的媒体中适应和生长的hESC中心，hESC目前无法使用的资源 社区。 为希望建立HESC专业知识的新调查人员提供最新的培训 将向东南部的调查人员提供一项密集的2周基于实验室的培训计划。 这将涉及在定义的媒体和新技术中的文化方面，例如大规模hESC文化 以及适用于药物筛查的高密度培养。这些技术可用于优势 由定义的系统提供。 充当东南河口社区的技术资源 核心的技术专业知识将通过直接一对一的 联系，通过访问该计划网站上发布的信息，并通过便利 通过其他几种机制进行技术交流。 总体而言，核心旨在刺激东南部hESC研究的活动，并启用 调查人员通过获得强化培训计划的访问来进入该领域。核心将是 不断评估并将新技术引入其自身的活动范围。这些将被提供 作为培训计划的一部分或直接传播技术的研究人员 信息。与东南部干细胞领域的领导者的讨论表明核心将 在支持该地区的HESC活动中发挥至关重要的作用。