Cerbral Perfusion Imaging using Cone Beam Computed Tomography

使用锥形束计算机断层扫描进行脑灌注成像

• 批准号: 7537917
• 负责人: Wojciech Bartosz Zbijewski
• 金额: $ 10.04万
• 依托单位: XORAN TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7537917
• 关键词: Accident and Emergency department; Address; Admission activity; Adult; Algorithms; Area; Asses; Blood Volume; Bolus Infusion; Brain; Brain hemorrhage; Brain imaging; Caring; Cause of Death; Cerebral Ischemia; Cerebrovascular Circulation; Cerebrum; Characteristics; Consensus; Data; Development; Diagnosis; Ensure; Image; Infarction; Intensive Care Units; Iodine; Literature; Location; Maps; Modeling; Noise; Organ; Outcome; Patients; Perfusion; Plant Roots; Protocols documentation; Public Health; Range; Rate; Recurrence; Research; Rotation; Sampling; Scanning; Signal Transduction; Slice; Speed; Staging; Standards of Weights and Measures; Stroke; System; Technology; Testing; Time; Tissues; United States; Vascular blood supply; X-Ray Computed Tomography; acute stroke; attenuation; base; cone-beam computed tomography; detector; digital; disability; experience; image reconstruction; imaging detector; improved; interest; novel strategies; portability; reconstruction; simulation; soft tissue; tool

DESCRIPTION (provided by applicant): Stroke is the leading cause of adult disability and third leading cause of death in the United States with approximately 700,000 new or recurrent strokes each year. Perfusion Computed Tomography (PCT) provides maps of parameters such as cerebral blood flow, volume and transit times. These parameters can be used to distinguish between ischemic and hemorrhagic stroke, to determine the location and extent of the hypoperfused area, and also to differentiate between the irreversibly damaged and salvageable tissue. We will investigate the feasibility of implementing PCT on a mobile, flat-panel detector, cone-beam CT (CBCT) system. Using such a platform will address two shortcomings of current PCT technology: lack of whole-brain coverage and limited accessibility in the emergency department and intensive care unit. We will focus on two issues: 1) relatively low scanning speed of flat-panel-based CBCT, which may hamper temporal sampling of contrast dynamics; and 2) increased projection noise and limited dynamic range of flat-panel detectors. In this project we will first experimentally investigate the characteristics of flat- panel detectors for imaging iodine enhanced vessels with respect to image noise and contrast. In the second stage of the research we will develop and validate a model- based, iterative algorithm for reconstruction of dynamic projection data acquired with relatively slowly rotating systems. PUBLIC HEALTH RELEVANCE: Stroke is the leading cause of adult disability and third leading cause of death in the United States with approximately 700,000 new or recurrent strokes each year. The mobile flat-panel-based CT system capable of perfusion imaging proposed here will allow for rapid assessment of neurovascular function of the whole brain directly in the emergency department. This tool may bring about improvements in stroke diagnosis and provide important support for treatment decisions, thus greatly improving outcome for acute strokes victims.

描述（由申请人提供）：中风是美国成人残疾的主要原因和第三大死亡原因，每年约有 700,000 例新发或复发中风。灌注计算机断层扫描 (PCT) 提供脑血流量、容量和传输时间等参数图。这些参数可用于区分缺血性和出血性中风，确定灌注不足区域的位置和范围，还可以区分不可逆损伤和可挽救的组织。我们将研究在移动平板探测器、锥形束 CT (CBCT) 系统上实施 PCT 的可行性。使用这样的平台将解决当前 PCT 技术的两个缺点：缺乏全脑覆盖以及急诊科和重症监护室的可及性有限。我们将重点关注两个问题：1）基于平板的 CBCT 扫描速度相对较低，这可能会妨碍对比度动态的时间采样； 2）投影噪声增加，平板探测器的动态范围有限。在这个项目中，我们将首先通过实验研究用于成像碘增强血管的平板探测器在图像噪声和对比度方面的特性。在研究的第二阶段，我们将开发并验证一种基于模型的迭代算法，用于重建通过相对缓慢的旋转系统获取的动态投影数据。公共健康相关性：中风是美国成人残疾的主要原因，也是美国第三大死亡原因，每年约有 700,000 例新发或复发中风。这里提出的能够进行灌注成像的移动平板 CT 系统将允许直接在急诊科快速评估整个大脑的神经血管功能。该工具可能会改善中风诊断，并为治疗决策提供重要支持，从而大大改善急性中风患者的预后。