Neurocognitive Mechanisms of Sentence Production Impairment in Aphasia

失语症句子产生障碍的神经认知机制

• 批准号: 10735595
• 负责人: Yasmeen Faroqi Shah
• 金额: $ 62.39万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-15 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10735595
• 关键词: Address; Agrammatism; Anatomy; Aphasia; Architecture; Area; Brain region; Broca Aphasia; Chronic; Clinical effectiveness; Communication; Communication impairment; Data; Development; Diagnosis; Dimensions; Disease; Elderly; Electromyography; Foundations; Goals; Impairment; Individual; Inferior frontal gyrus; Intervention; Language; Language Disorders; Left; Lesion; Linguistics; Magnetoencephalography; Measurement; Modeling; Morphology; National Institute on Deafness and Other Communication Disorders; Nerve Degeneration; Neuroanatomy; Neurocognitive; Occupations; Outcome; Participant; Personal Communication; Persons; Prevention; Process; Production; Public Health; Quality of life; Research; Research Proposals; Retrieval; Semantics; Specific qualifier value; Speech; Speed; Stroke; Symptoms; Testing; Time; Variant; Work; cognitive process; comorbidity; disability; improved; innovation; language impairment; lexical; neural; neural model; neuromechanism; neurophysiology; novel; post intervention; post stroke; programs; spatiotemporal; stroke survivor; stroke-induced aphasia; symptom cluster; syntax; theories

PROJECT SUMMARY Post-stroke agrammatic aphasia (PSA-G) is characterized by a cluster of symptoms (fragmented sentences, errors in functional morphology, a dearth of verbs, and slow speech rate), yet extant theories and language interventions focus on individual symptoms. This single-symptom theoretical and intervention focus results in limited gains in functional communication. The long-term goal of this research is to improve the clinical effectiveness of interventions for PSA-G. As a first step towards this goal, this project’s objective is to advance the theoretical framework of PSA-G by addressing two critical gaps. The first gap is in the mechanistic understanding of how lexical, grammatical, motoric, and cognitive processes work together to enable fluent sentence production and how this breaks down in PSA-G. The second gap is in the understanding of neural mechanisms underlying how sentence production planning normally unfolds over time and what crucial spatiotemporal alterations give rise to PSA-G versus other variants of post-stroke aphasia with predominantly lexico-semantic deficits (PSA-LS). The central hypothesis is that agrammatic language production results from spatiotemporal alterations in the neural dynamics of morphosyntactic and phonomotor processes, causing a cumulative processing bottleneck at the point of articulatory planning. This Synergistic Processing Bottleneck Model of Agrammatism will be tested with two specific aims. Specific Aim 1 will elucidate the relative contribution of syntactic and non-syntactic processes towards sentence production in aphasia by using speed metrics and a path modeling framework. The expected outcomes of this aim are an improved understanding of the extent to which delays in different linguistic processes underlying the agrammatic symptom cluster impair fluent sentence production in aphasia generally, and in PSA-G versus PSA-LS more specifically. Specific Aim 2 will determine the neural mechanisms underlying sentence production across language deficit profiles. Magnetoencephalography (MEG) will be used to compare alterations in timecourse and functional connectivity of key perilesional and contralesional syntactic hubs across increasingly demanding morphosyntactic production tasks. The expected outcome of this aim is a spatiotemporally specified neural model of sentence production in neurotypical, PSA-G, and PSA-LS speakers. The significance this research is that it will forward an empirically established multidimensional model of sentence production, which will lay the foundation for developing more targeted and effective language interventions for agrammatic aphasia. It will also contribute to a better understanding of agrammatism in neurodegenerative aphasias. The innovative aspects of this project include: a novel multidimensional theoretical framework that incorporates non-syntactic dimensions of phonomotor planning, processing capacity and speed, and neurophysiological dynamics; direct comparisons between PSA- G and PSA-LS groups; and MEG analysis of spoken language with simultaneous electromyographic measurement.

项目概要 中风后语法失语症 (PSA-G) 的特点是出现一系列症状（支离破碎的句子、 功能形态错误、动词缺乏和语速缓慢），但现存的理论和语言 干预措施侧重于个体症状。这种单一症状理论和干预措施的结果是。 这项研究的长期目标是改善临床功能。 PSA-G 干预措施的有效性 作为实现这一目标的第一步，该项目的目标是推进。 通过解决两个关键差距来构建 PSA-G 的理论框架。第一个差距是机制方面的。 了解词汇、语法、运动和认知过程如何协同工作以实现流利 句子的产生以及 PSA-G 中的句子产生方式如何分解 第二个差距在于对神经的理解。 句子生产计划通常如何随着时间的推移展开的机制以及什么是关键的 与中风后失语症的其他变体相比，时空变化引起 PSA-G 词汇语义缺陷（PSA-LS）的中心假设是非语法语言产生的结果。 形态句法和语音运动过程的神经动力学的时空变化，导致 关节计划点的累积处理瓶颈 这种协同处理瓶颈。 语法主义模型将测试两个具体目标，具体目标 1 将阐明相对贡献。 通过使用速度指标和 该目标的预期结果是加深对路径建模框架的理解。 导致语法症状群背后不同语言过程的延迟，损害句子的流畅性 一般失语症的产生，以及更具体的 PSA-G 与 PSA-LS 的产生将决定。 跨越语言缺陷的句子生成的神经机制。 脑磁图（MEG）将用于比较时间进程和功能连接的变化 关键的周围和对侧句法中心越来越多地跨越要求较高的形态句法生产 该目标的预期结果是一个时空指定的句子生成神经模型。 神经典型、PSA-G 和 PSA-LS 说话者这项研究的意义在于它将提出一个实证研究。 建立了句子生成的多维模型，为开发更多句子奠定了基础 针对语法失语症进行有针对性和有效的语言干预也将有助于更好地治疗。 对神经退行性失语症的语法错误的理解该项目的创新之处包括： 新颖的多维理论框架，融合了语音运动的非句法维度 PSA-之间的计划、处理能力和速度以及神经生理学动力学的直接比较； G 组和 PSA-LS 组；以及同步肌电图的口语 MEG 分析 测量。